Marine Microbes-Derived Anti-Bacterial Agents

Lü, Xiaoling; Cao, Xin; Liu, X.; Jiao, Bo

doi:10.2174/1389557511009011077

Cited by 14 publications

(15 citation statements)

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“…It has been recognized that metabolites synthesized by marine microorganisms associated with sponges could become a major source for the discovery of new drugs, not only because the biological diversity in marine ecosystems like coral reefs or deep sea floors is probably higher than in the rainforest, but because marine microorganisms offer a renewable resource for the scale-up and development of potentially new drugs [101,102]. …”

Section: New Compounds and Their Distribution 2001–2010mentioning

confidence: 99%

Marine Sponge Derived Natural Products between 2001 and 2010: Trends and Opportunities for Discovery of Bioactives

et al. 2014

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Marine sponges belonging to the phylum Porifera (Metazoa), evolutionarily the oldest animals are the single best source of marine natural products. The present review presents a comprehensive overview of the source, taxonomy, country of origin or geographical position, chemical class, and biological activity of sponge-derived new natural products discovered between 2001 and 2010. The data has been analyzed with a view to gaining an outlook on the future trends and opportunities in the search for new compounds and their sources from marine sponges.

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Section: New Compounds and Their Distribution 2001–2010mentioning

confidence: 99%

Marine Sponge Derived Natural Products between 2001 and 2010: Trends and Opportunities for Discovery of Bioactives

et al. 2014

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“…[198]; marine pharmacology in Australia: the Roche Research Institute [199]; the global marine pharmaceutical pipeline in 2010: U.S. Food and Drug Administration-approved compounds and those in Phase I, II and III of clinical development [200]; marine drugs from sponge-microbe associations [201]; cyanobacteria as an emerging source for drug discovery [202]; marine invertebrates as a future therapeutic treasure [203]; biodiversity conservation and marine natural products drug discovery [204]; marine invertebrates as a source of guanidines with chemical and pharmacological significance [205]; innovations in the field of marine natural products and a new wave of drugs [206]; (b) antimicrobial marine pharmacology : antibacterial marine natural products [207]; marine microbes and pharmaceutical development [208]; marine microbe-derived antibacterial agents [209]; antimicrobial peptides from marine invertebrates [210]; novel anti-infective compounds from marine bacteria [211]; conventional and unconventional antimicrobials from fish, marine invertebrates and microalgae [212]; (c) antiviral marine pharmacology : antiviral lead compounds from marine sponges [213]; potential anti-HIV agents from marine resources [214]; marine compounds and their antiviral activities [215]; marine organisms as a therapeutic source against herpes simplex virus infection [216]; (d) antiparasitic, antituberculosis, antimalarial and antifungal marine pharmacology : antiparasitic marine invertebrate-derived small molecules [217]; marine antileishmanial natural products [218]; antituberculosis leads from marine microbial metabolites [219]; antimalarial drug discovery from marine sources between January 2003 and December 2008 [220]; antimalarial marine natural products from 2006 to 2008 [221]; antimalarial marine compounds [222]; (e) immuno- and anti-inflammatory marine pharmacology : marine natural product leads for treatment of inflammation [223]; marine natural products targeting phospholipase A 2 [224]; marine diterpene glycosides as anti-inflammatory agents [225]; anti-inflammatory compounds from marine algae [226]; (f) cardiovascular marine pharmacology : marine-derived angiotensin-I-converting enzyme inhibitors [227]; (g) nervous system marine pharmacology : conotoxins as natural products drug leads [...…”

Section: Reviews On Marine Pharmacologymentioning

confidence: 99%

Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action

et al. 2013

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The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series. The pharmacology of structurally-characterized compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner. Antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral pharmacological activities were reported for 102 marine natural products. Additionally, 60 marine compounds were observed to affect the immune and nervous system as well as possess antidiabetic and anti-inflammatory effects. Finally, 68 marine metabolites were shown to interact with a variety of receptors and molecular targets, and thus will probably contribute to multiple pharmacological classes upon further mechanism of action studies. Marine pharmacology during 2009–2011 remained a global enterprise, with researchers from 35 countries, and the United States, contributing to the preclinical pharmacology of 262 marine compounds which are part of the preclinical pharmaceutical pipeline. Continued pharmacological research with marine natural products will contribute to enhance the marine pharmaceutical clinical pipeline, which in 2013 consisted of 17 marine natural products, analogs or derivatives targeting a limited number of disease categories.

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“…Some endophytic microorganisms including bacteria can contribute to host defense by excretion of antibiotics and other bioactive substances. Thus, marine microorganisms offer an excellent resource for the discovery of new compounds with interesting biological activities, including antimicrobial, antifungal, antiprotozoal, antituberculosis and antiviral (Lu et al 2010;Rahman et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Short Communication: Fish fauna of Lake Lauik Tawar and Lake Laulo, Simeulue Island, Indonesia

Muchlisin¹,

Nurfadillah²,

Arisa³

et al. 2017

Biodiversitas

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Abstract. Fitri DS, Pangastuti A, Susilowati A, Sutarno. 2017. Endophytic bacteria producing antibacterial against methicillin-resistant Staphylococcus aureus (MRSA) in seagrass from Rote Ndao, East Nusa Tenggara,. Methicillinresistant Staphylococcus aureus (MRSA) are bacteria that resistant to the various type of antibiotics and yet cannot be handled comprehensively. The discovery of new antibiotic from endophytic bacteria in seagrass of Rote Island is an option to overcome the resistance. The aims of this research were to screen endophytic bacteria inhibit MRSA from seagrass, to determine the species of the endophytic bacteria and the genetic relationship. Isolation of endophytic bacteria has carried out by inoculating surface sterilization seagrass leaves on Marine Agar (MA) medium. Selection of potential endophytic bacteria-producing anti-MRSA has done using overlay method against MRSA, gram-positive Bacillus subtilis, and gram-negative Escherichia coli. Identification of the endophytic bacteria based on the sequence of 16S rRNA encoding gene. The results showed that there were eight isolates of endophytic bacteria which have antibacterial activity against MRSA of seagrass Enhalus acoroides, Thalassia hemprichii, and Cymodocea rotundata in the Litianak and Oeseli Beaches, Rote Ndao. The diameter of inhibition zone was between 0.65-18.27 mm with narrow spectrum with broad spectrum antibacterial activity. The eight potential endophytic bacteria identity were Bacillaceae E2M1, Bacillaceae E2M3, Bacillus E2M4, Bacillus E2M7, Bacillaceae E2M8, Pseudomonadaceae C1M7, Shewanellaceae C2M3, and Rhodobacteraceae T1M3. Most of the isolates can be said to be a new species as the percent similarity of 16S rRNA gene sequence was less than 95% and promising to produce new antibacterial compounds. Phylogenetic relationship showed some isolates clustering in different groups that present the diverse groups of endophytic bacteria were found.

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Marine Microbes-Derived Anti-Bacterial Agents

Cited by 14 publications

References 0 publications

Marine Sponge Derived Natural Products between 2001 and 2010: Trends and Opportunities for Discovery of Bioactives

Marine Sponge Derived Natural Products between 2001 and 2010: Trends and Opportunities for Discovery of Bioactives

Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action

Short Communication: Fish fauna of Lake Lauik Tawar and Lake Laulo, Simeulue Island, Indonesia

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