Markers of and Risk Factors for the Development and Progression of Diabetic Kidney Disease

MacIsaac, Richard J; Ekinci, Elif I; Jerums, George

doi:10.1053/j.ajkd.2013.10.048

Cited by 291 publications

(280 citation statements)

References 128 publications

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“…These observations suggest that elimination of a major contributor to the pathology (i.e., excess salt intake, adenine diet, or DOCA treatment) could lead to regression of renal injury. Although multiple causes are intricately involved in the pathogenesis of renal injury in a clinical setting (Macisaac et al, 2014;Drawz and Rahman, 2015), these findings support the concept that identification of the main pathways involved in kidney injury and targeted intensive treatment may lead to regression of renal injury.…”

Section: Induction Of Urinary Nasupporting

confidence: 65%

CS-3150, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, Shows Preventive and Therapeutic Effects On Renal Injury in Deoxycorticosterone Acetate/Salt-Induced Hypertensive Rats

Arai

Morikawa

Ubukata

et al. 2016

Journal of Pharmacology and Experimental Therapeutics

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The present study was designed to assess both preventive and therapeutic effects of (S)-1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl) phenyl]-5-[2-(trifluoromethyl) phenyl]-1H-pyrrole-3-carboxamide (CS-3150), a novel nonsteroidal mineralocorticoid receptor antagonist, on renal injury in deoxycorticosterone acetate (DOCA)/salt-induced hypertensive rats (DOCA rats). From 7 weeks of age, DOCA was subcutaneously administered once a week for 4 weeks to uninephrectomized rats fed a high-salt diet. In experiment 1, CS-3150 (0.3-3 mg/kg) was orally administered once a day for 4 weeks coincident with DOCA administration. In experiment 2, after establishment of renal injury by 4 weeks of DOCA/salt loading, CS-3150 (3 mg/kg) was orally administered once a day for 4 weeks with or without continuous DOCA administration. In experiment 1, DOCA/salt loading significantly increased systolic blood pressure (SBP), which was prevented by CS-3150 in a dose-dependent manner. Development of renal injury (proteinuria, renal hypertrophy, and histopathological changes in glomeruli and tubule) was also suppressed by CS-3150 with inhibition of mRNA expression of fibrosis, inflammation, and oxidative stress markers. In experiment 2, under continuous DOCA treatment, CS-3150 clearly ameliorated existing renal injury without lowering SBP, indicating that CS-3150 regressed renal injury independent of its antihypertensive action. Moreover, CS-3150 treatment in combination with withdrawal of DOCA showed further therapeutic effect on renal injury accompanied by reduction in SBP. These results demonstrate that CS-3150 not only prevents but also ameliorates hypertension and renal injury in DOCA rats. Therefore, CS-3150 could be a promising agent for the treatment of hypertension and renal disorders, and may have potential to promote regression of renal injury.

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Section: Induction Of Urinary Nasupporting

confidence: 65%

CS-3150, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, Shows Preventive and Therapeutic Effects On Renal Injury in Deoxycorticosterone Acetate/Salt-Induced Hypertensive Rats

Arai

Morikawa

Ubukata

et al. 2016

Journal of Pharmacology and Experimental Therapeutics

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“…There is growing clinical evidence to suggest a direct or indirect association between periodontitis and kidney dysfunction (Macisaac et al, 2014; Grubbs et al, 2015). Furthermore, there is a positive correlation between periodontal disease and obesity, hypertension, hyperlipidemia, or hyperglycemia (Zhou, Zhang, Liu, Zhang, & Li, 2015), although the molecular mechanisms of these relationships are unclear.…”

Section: Discussionmentioning

confidence: 99%

“…DM is an important health problem because it has become the leading cause of chronic kidney disease (CKD; Nashar & Egan, 2014), and the concomitant conditions might affect the quality of life of patients. It has been reported that diabetic nephropathy occurs in up to 40% of patients with type 1 or type 2 DM (Macisaac, Ekinci, & Jerums, 2014). Diabetic nephropathy is a significant risk factor of progression to end‐stage renal disease, resulting in the need for dialysis.…”

Section: Introductionmentioning

confidence: 99%

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Naruishi

Oishi

Inagaki

et al. 2016

Clinical & Exp Dental Res

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Recent studies have demonstrated that chronic kidney disease (CKD) may be associated with the progression of periodontal disease. Diabetes mellitus (DM) is a major risk factor for CKD. The objective of this study was to clarify the relationship between periodontal condition and kidney dysfunction in patients who had kidney failure with or without DM. One hundred sixty‐four patients with kidney dysfunction were enrolled (male: N = 105; female: N = 59), and the relationship between periodontal condition and kidney dysfunction was analyzed in a cross‐sectional study. The subjects were divided into three groups: (a) patients with DM, (b) dialysis patients with nephropathy due to various kidney diseases, and (c) dialysis patient with nephropathy due to DM (diabetic nephropathy). Then, the effect of DM on the periodontal condition was analyzed. The patients were also stratified by CKD stage (into G1–G5) using the estimated glomerular filtration rate (eGFR), and the G5 group was divided in patients with or without DM. Correlations between eGFR and parameters of periodontal condition were calculated in patients from G1 to G4. The number of missing teeth was significantly higher in dialysis patients with diabetic nephropathy than in patients with DM, whereas alveolar bone loss did not show a significant difference among the three groups. In addition, the G5 patients with DM had a significantly higher number of missing teeth than the other CKD groups, whereas alveolar bone loss did not show a significant difference. In G5 patients with DM, Community Periodontal Index and Oral Hygiene Index scores were significantly higher than in G1‐4 patients with DM. There was a significant negative correlation between eGFR and the number of missing teeth. Patients with diabetic nephropathy have a higher rate of periodontal problems such as missing teeth in Japanese adults.

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“…Furthermore, approximately 25% of patients with DM have normal UA, and the diagnosis of DKD is based on reduced GFR levels only 18 . Nevertheless, even though other new kidney disease biomarkers have been investigated, none of them demonstrated better diagnostic performance than albuminuria in screening for DKD 19 . Recent investigations with proteomics approach suggest that this technique, in a near future, might be able to identify diabetes renal involvement earlier 20 .…”

Section: Discussionmentioning

confidence: 99%

Availability of urinary albumin measurement in Southern Brazilian Laboratories

Soares¹,

Cheuiche²,

Silva³

et al. 2015

cbr

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Markers of and Risk Factors for the Development and Progression of Diabetic Kidney Disease

Cited by 291 publications

References 128 publications

CS-3150, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, Shows Preventive and Therapeutic Effects On Renal Injury in Deoxycorticosterone Acetate/Salt-Induced Hypertensive Rats

CS-3150, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, Shows Preventive and Therapeutic Effects On Renal Injury in Deoxycorticosterone Acetate/Salt-Induced Hypertensive Rats

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Availability of urinary albumin measurement in Southern Brazilian Laboratories

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