Masculinization of the female golden hamster by neonatal treatment with androgen or estrogen

Paup, Donald C.

doi:10.1016/0018-506x(72)90014-1

Cited by 80 publications

(23 citation statements)

References 22 publications

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“…For example, in the rat many of the organizing effects of testosterone also can be induced by administration of estradiol (Paup et al 1972). This is possible because specific regions of the brain contain aromatase, which enables the conversion of testosterone into estradiol (Paup et al 1972;Reddy et al 1974). Inhibition of aromatase activity by pharmacologic antagonists feminizes sexual behavior of male rats (Gladue and Clemens 1980;McEwen 1981).…”

Section: Role Of Androgens In Reproductive and Behavioral Developmentmentioning

confidence: 99%

Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat.

Hotchkiss

Ostby

VanDenburgh

et al. 2002

Environ Health Perspect

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In mammals, exposure to androgens early in development is essential for masculinization of the male reproductive phenotype. Male fetuses exposed to antiandrogens during perinatal life are permanently demasculinized in their morphology and physiology, whereas exposure to exogenous androgens permanently masculinizes females. In some litter-bearing species, proximity in utero of females to males can partially masculinize female siblings and alter their responsiveness to endocrine-disrupting compounds. However, in our strain of rat (CD-SD Charles River), intrauterine position does not significantly influence testosterone concentrations and anogenital distance of fetuses. In comparison, administration of testosterone propionate to pregnant females, at doses that doubled fetal female testosterone levels, did masculinize the reproductive system. Discovery of androgen-active chemicals in the environment has placed increased emphasis on describing the reproductive and behavioral effects of both natural and environmental androgens and antiandrogens. Recently, the effects of an antiandrogen, vinclozolin, on the brain and behavior were cited as a special concern by the U.S. Environmental Protection Agency in its risk assessment of this pesticide. In rats, one such behavior that is perinatally organized by androgens is social play. Males play more than females, and administration of exogenous androgens during the neonatal period alters the juvenile expression of this sexually dimorphic behavior. Vinclozolin is an androgen receptor antagonist that inhibits androgen-dependent tissue growth in vivo. We were interested in whether developmental exposure to vinclozolin could also alter androgen-dependent behaviors such as play. Neonatal male rats were injected on postnatal days (PNDs) 2 and 3 with corn oil, the pharmacologic antiandrogen flutamide (50 mg/kg), or vinclozolin (200 mg/kg). On PNDs 36-37 animals were observed for social play. Behaviors associated with general social activity such as sniffing and dorsal contact were unaffected by treatment. However, play behavior in males treated with flutamide or vinclozolin was significantly reduced, resembling levels of play characteristic of females rather than untreated males. Therefore, this study demonstrates that perinatal exposure to vinclozolin, an environmental antiandrogen, can alter androgen-dependent play behavior in the male rat.

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Section: Role Of Androgens In Reproductive and Behavioral Developmentmentioning

confidence: 99%

Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat.

Hotchkiss

Ostby

VanDenburgh

et al. 2002

Environ Health Perspect

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“…All hormones employed increased ano-genital distance and the diameter of the urethro-vaginal canal, but only TP and diethylstilboestrol suppressed oestro¬ gen-progesterone-induced lordosis. In a previous study, we found that treatment with TP, testosterone or androsterone neonatally resulted in significant enhancement of priapian development in adult female hamsters, whereas treatment with diethyl¬ stilboestrol had no effect (Paup et al 1972). In addition, TP, testosterone and diethyl¬ stilboestrol induced behavioural masculinization, whereas androsterone was ineffec¬ tive.…”

Section: Resultsmentioning

confidence: 96%

“…In contrast to the ineffectiveness of testosterone in defeminizing adult female hamsters, the free form of testosterone has been shown to be as potent as testosterone propionate in behavioural masculinization of these females (Paup et al 1972). Thus, female hamsters treated perinatally with free testosterone behave similarly to both normal female rats and male rats castrated on the day of birth in that they are capable of showing high levels of both lordotic behaviour and mounting frequency.…”

Section: Resultsmentioning

confidence: 97%

“…Before the female behaviour tests reported here were conducted, the females were tested weekly for male behaviour after treatment with TP. The results of these tests have been reported separately (Paup et al 1972). The tests for female behaviour were separated from the tests for male behaviour by at least 6 weeks with no hormone treatment.…”

Section: Methodsmentioning

confidence: 97%

“…In the hamster, however, treat¬ ment with oestradiol benzoate perinatally was reported to disrupt gonadal function, but failed to suppress sexual receptivity after oestrogen and progesterone replace-56 Linda P. Coniglio, D. C. Paup and L. G. Clemens ment in adulthood (Ciaccio & Lisk, 1971). More recently we have reported the induc¬ tion of behavioural masculinization in female hamsters with perinatal treatment of the synthetic oestrogen, diethylstilboestrol and the non-propionate form of testo¬ sterone (Paup, Coniglio & Clemens, 1972). Since diethylstilboestrol was effective in inducing mounting behaviour and since testosterone was as effective as TP in this regard, the present study was designed to test the defeminizing potential of these hormones.…”

Section: Introductionmentioning

confidence: 96%

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Hormonal Specificity in the Suppression of Sexual Receptivity of the Female Golden Hamster

Coniglio

Paup

Clemens

1973

Journal of Endocrinology

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Oestrogen\p=m-\progesterone-induced lordosis behaviour was suppressed in female hamsters which received neonatal treatment with testosterone propionate or diethylstilboestrol. No suppression of lordosis was observed in females which received neonatal treatment with testosterone, androsterone or control substances. In addition, the ano\p=m-\genital distance and diameter of the vaginal orifice were increased in females treated with testosterone, testosterone propionate, androsterone or diethylstilboestrol.However, testosterone, testosterone propionate and androsterone had a greater effect on ano\p=m-\genital distance than did diethylstilboestrol. Possible mechanisms for the defeminizing action of the hormones administered were discussed.

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Female Reproductive Toxicology

Goldman

Cooper

Ralph³

2015

Mammalian Toxicology

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Masculinization of the female golden hamster by neonatal treatment with androgen or estrogen

Cited by 80 publications

References 22 publications

Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat.

Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat.

Hormonal Specificity in the Suppression of Sexual Receptivity of the Female Golden Hamster

Female Reproductive Toxicology

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