Mass screening programmes and trends in cervical cancer in Finland and the Netherlands

Aa, Maaike A. van der; Pukkala, Eero; Coebergh, Jan Willem; Anttila, Ahti; Siesling, Sabine

doi:10.1002/ijc.23276

Cited by 81 publications

(46 citation statements)

References 32 publications

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“…22) and the present study]. This might be explained by the efficiency of the Dutch screening program, with an abnormal cytology rate of only 1.8% (34), a long screening interval (5-year), a high age at which screening starts (at the age of 30), and a low percentage of excess smear use (35).…”

Section: Discussionmentioning

confidence: 51%

Primary hrHPV DNA Testing in Cervical Cancer Screening: How to Manage Screen-Positive Women? A POBASCAM Trial Substudy

Dijkstra

Niekerk

Rijkaart

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

101

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Background: High-risk human papillomavirus (hrHPV) testing has higher sensitivity but lower specificity than cytology for cervical (pre)-cancerous lesions. Therefore, triage of hrHPV-positive women is needed in cervical cancer screening.Methods: A cohort of 1,100 hrHPV-positive women, from a population-based screening trial (POBASCAM: n ¼ 44,938; 29-61 years), was used to evaluate 10 triage strategies, involving testing at baseline and six months with combinations of cytology, HPV16/18 genotyping, and/or repeat hrHPV testing. Clinical endpoint was cervical intraepithelial neoplasia grade 3 or worse (CIN3

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Section: Discussionmentioning

confidence: 51%

Primary hrHPV DNA Testing in Cervical Cancer Screening: How to Manage Screen-Positive Women? A POBASCAM Trial Substudy

Dijkstra

Niekerk

Rijkaart

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

101

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“…An early cervical cancer-screening program in a population of 22,106 women aged over 25 years in a rural county of China indicated that the relative risk of cervix cancer was 0.33 in women with three or more negative smear tests [13] , supporting the cervical cancer screening is an efficient method for cervical cancer control [14,15] .…”

Section: Discussionmentioning

confidence: 99%

Incidence and mortality trend of cervical cancer in 11 cancer registries of China

Tao

Mao

Liu

et al. 2011

Chin. J. Cancer Res.

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Objective: In many countries, the cervical cancer prevalence has declined but less information about the changes is available in China. This study aims to understand the epidemiological characteristics and trend of cervical cancer in China.Methods: Cervical cancer data of 11 cancer registries during 1988-2002 in China were analyzed. The age and urban/rural differences and trend of cervical cancer incidence and mortality were described and discussed.Results: During 1988-2002, a total of 6007 incidence cases and 3749 mortality cases of cervical cancer were reported in the 11 cancer registries. The incidence crude rate of cervical cancer was 3.80/100,000 and the world age adjusted rate was 2.78/100,000. In the same period, the mortality crude rate was 2.37/100,000 and the world age adjusted rate was 1.66/100,000. Declined incidence and mortality trends were observed during this period in urban as well as in rural areas. When calculating the rates by age group, we found that the declining trends were only for older women and increasing trends for younger women, especially for women in the rural areas. Conclusion:The incidence and mortality rates declined during the period of 1988-2002 in China for older women. The younger women showed an increasing trend during the same period, especially for women in rural area.

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“…1 These declines can partly be described as natural declines but are also the result of developments in the prevention and treatment of cervical cancer. 2,3 Cervical cancer screening leads to the detection and treatment of cervical intraepithelial neoplasia (CIN). CIN is considered to be a preinvasive precursor of invasive cancer and a reduction in incidence and mortality is expected because CIN management is found to be highly effective.…”

mentioning

confidence: 99%

Trends in cervical cancer in the Netherlands until 2007: Has the bottom been reached?

Kok

Ballegooijen

et al. 2011

Intl Journal of Cancer

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We explored trends in incidence and mortality of cervical cancer by age, stage and morphology, and linked the observed trends to screening activities. Data was retrieved from the Netherlands Cancer Registry during 1989-2007 (incidence) and Statistics Netherlands during 1970. Trends were evaluated by calculating the estimated annual percentage change (EAPC). Joinpoint regression analysis was used to detect changes in trends. Cervical intraepithelial neoplasia (CIN) detection rates were calculated by data from ''the nationwide network and registry of histo-and cytopathology '' during 1990-2006. Total age-adjusted incidence rate (European standardized rate (ESR)) was 7.9 per 100,000 woman years in 2007. During 1989-1998, incidence rates decreased with an EAPC of 21.3% (95% confidence interval ( 24.6% to 23.7%), and with 22.6% (95% CI: 23.8% to 21.5%) during 1994-2007. The observed trend in total incidence is similar to the trend in squamous cell carcinomas in age group 35-54 years, suggesting that the observed trends are likely to be associated to changes in the screening program. This is supported by the trend in CINIII detection rates. In conclusion, incidence and mortality overall decreased and leveled off. On top of that there was an extra decrease that was compensated by a following recent increase in incidence, probably resulting from reorganization of the Dutch screening program.In the Netherlands, over the past decades, incidence and mortality trends of cervical cancer have been steadily declining, with rates of 6.3 and 1.4 per 100,000 woman years (ageadjusted rates, standardized to the World population), respectively in 2007. 1 These declines can partly be described as natural declines but are also the result of developments in the prevention and treatment of cervical cancer. 2,3 Cervical cancer screening leads to the detection and treatment of cervical intraepithelial neoplasia (CIN). CIN is considered to be a preinvasive precursor of invasive cancer and a reduction in incidence and mortality is expected because CIN management is found to be highly effective. 4 An additional mortality reduction is expected from the preclinical detection of early invasive cases, which have a relatively good prognosis. 5 Since the 1980s, cervical cancer screening using the Pap smear test has been offered to the population in the Netherlands through an organized program initially inviting all women between 35 and 54 years every 3 years. The evidence gathered in the Netherlands in the early 1990s pointed toward a suboptimal performing screening program, in terms of both the organization and the efficiency of screening of the target population. 6-9 Based on a request from the Ministry of Health for possible solutions, 10 new protocols and

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Mass screening programmes and trends in cervical cancer in Finland and the Netherlands

Cited by 81 publications

References 32 publications

Primary hrHPV DNA Testing in Cervical Cancer Screening: How to Manage Screen-Positive Women? A POBASCAM Trial Substudy

Primary hrHPV DNA Testing in Cervical Cancer Screening: How to Manage Screen-Positive Women? A POBASCAM Trial Substudy

Incidence and mortality trend of cervical cancer in 11 cancer registries of China

Trends in cervical cancer in the Netherlands until 2007: Has the bottom been reached?

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