Mass spectrometry of methylated pseudoaldobiouronic acids

THE EFFECT OF pH ON THE FLUORESCENCE OF COMPLEXES OF HUMAN SERUM ALBUMIN AND BOVINE SERUM ALBUMIN WITH BILIRUBIN

“…The molecule is often drawn as a linear tetrapyrrole ( Fig. 2a) but in some organic solvents (Kuenzle, 1970;Kuenzle et al, 1973) and the crystal (Bonnett, 1976) it has been shown that the two molecular halves are linked by from two to six intramolecular hydrogen bonds. Ionization of the propionic acid and/or pyrrole protons will disrupt some or all of the intramolecular hydrogen bonds and thus, in some sense, open up the molecule.…”

A novel conjugate as a major metabolite of bromperidol in man

“…We are not aware of any reports of glucofuranosiduronolactone conjugates of exogenous compounds, and although Hignite et a1 (1981) have shown that glucofurano-and glucopyranosiduronic acid ester conjugates of clofibrate are excreted by man, there was no evidence to suggest that the clofibrate furanose conjugate was converted to the lactone during isolation. Kuenzle (1970) has identified several disaccharide conjugates of bilirubin present in human bile, one of which was an acyl4-O-P-~-glucofuranosyluronic acid acid/D-glucopyranoside. Unless glucuronide conjugates are iden-tified by direct techniques such as mass spectrometry, it is unlikely that other procedures will distinguish between pyranose and furanose forms.…”

UDP‐glucuronyltransferase in Perfused Rat Liver and in Microsomes

“…However in liver perfusion bile most of the radioactivity was found among the nonglucuronide azopigments ( Table 1 b). Marked increases of abnormal azopigments have been observed after prolonged obstruction of the bile duct [12]. Cholestasis of very short duration may occur in the isolated perfused liver since usually a 20 -30-min period of reduced bile flow was observed following hepatectomy.…”

“…Cholestasis of very short duration may occur in the isolated perfused liver since usually a 20 -30-min period of reduced bile flow was observed following hepatectomy. Ether anesthesia alone causes a prompt decrease of bile flow and a transient increase of azopigments of the y fraction [12]. However, it still remains to be established whether short-term cholestasis is the reason for the altered bile pigment composi- (Table 1).…”

“…The microsomal model system only deals with the formation of bilirubin glucuronides and glucosides. However under pathological conditions the still unidentified and y azopigment fractions are primarily increased in bile [12]. Hence the underlying mechanisms cannot be understood unless the structures of the abnormal bile pigments have been elucidated.…”