Mast cells are involved in the pathogenesis of indomethacin-induced rat enteritis

Okayama, Tetsuya; Yoshida, Norimasa; Uchiyama, Kazuhiko; Takagi, Tomohisa; Yoshikawa, Toshikazu

doi:10.1007/s00535-008-2267-5

Cited by 10 publications

(3 citation statements)

References 26 publications

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“…Gnotobiotic rats mono-associated with Bifidobacterium or Lactobacillus have no ulcers after NSAID administration, while mono-association with Escherichia coli or Eubacterium limosum induces ileal ulcer formation [71]. On the other hand, the development of intestinal lesions in response to indomethacin is prevented in mast cell-deficient rats [72]. It has been shown that orally administered GMP induces an increment in the amount of Lactobacillus and Bifidobacteria in the fecal microbiota of mice [73], and that this bioactive peptide avoids the adhesion of enterohemorrhagic E. coli O157:H7 on Caco-2 cells [74].…”

Section: Discussionmentioning

confidence: 99%

Glycomacropeptide Ameliorates Indomethacin-Induced Enteropathy in Rats by Modifying Intestinal Inflammation and Oxidative Stress

et al. 2020

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Nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy is considered a serious and increasing clinical problem without available treatment. Glycomacropeptide (GMP) is a 64-amino acid peptide derived from milk κ-casein with numerous biological activities. The aim of this study was to investigate the protective effect of GMP on NSAID enteropathy in rats. Enteropathy was induced by seven days oral indomethacin administration. Rats were orally GMP treated from seven days previous and during the establishment of the enteropathy model. Changes in metabolism, hematological and biochemical blood alterations, intestinal inflammation and oxidative damage were analyzed. Integrity barrier markers, macroscopic intestinal damage and survival rate were also evaluated. GMP treatment prevented anorexia and weight loss in animals. Furthermore, prophylaxis with GMP ameliorated the decline in hemoglobin, hematocrit, albumin and total protein levels. The treatment had no therapeutic efficacy on the decrease of occludin and mucin (MUC)-2 expression in intestinal tissue. However, GMP markedly decreased neutrophil infiltration, and CXCL1, interleukin-1β and inducible nitric oxide synthase expression. Nitric oxide production and lipid hydroperoxide level in the small intestine were also diminished. These beneficial effects were mirrored by preventing ulcer development and increasing animal survival. These results suggest that GMP may protect against NSAID enteropathy through anti-inflammatory and antioxidant properties.

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Section: Discussionmentioning

confidence: 99%

Glycomacropeptide Ameliorates Indomethacin-Induced Enteropathy in Rats by Modifying Intestinal Inflammation and Oxidative Stress

et al. 2020

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“…Indomethacin-induced gastric ulcer by inhibition of prostaglandins which are cytoprotective to gastric mucosa [11]. Moreover, it was reported that indomethacin causes significant gastrointestinal damage [12] and several enteropathic consequences, including oxidative stress [13].…”

Section: Introductionmentioning

confidence: 99%

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Sayed

Fahmy

Soliman

et al. 2016

Int J Pharm Pharm Sci

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Objective: The ethanolic extract of Vitis vinifera leaves (VVE) (500 mg/kg body weight), ranitidine (50 mg/kg body weight) and both of them were tested for their gastroprotective and curative effects against the incidence of peptic ulcer. Methods:The antiulcer effects of VVE were investigated using a combination of indomethacin and cold-stress for 2h. To ascertain the mechanism of action of VVE, its protective and curative effects were studied on gastric volume, gastric juice acidity, ulcer index and malondialdehyde (MDA), glutathione (GSH), catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD), nitric oxide (NO) activities of both stomach and duodenum of rats. Moreover, histopathological effects on stomach and duodenum were determined. Results:The antioxidant activity of VVE was demonstrated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) test. VVE was found to reduce the ulcer index, gastric volume and the level of gastric juice acidity. Also, VVE showed gastroprotective and curative activities mainly through improvement of antioxidant status and decreasing lipid peroxidation accompanied with amelioration of both stomach and duodenum architectures. Conclusion:The prophylactic and curative effects of VVE proved to be effective in preventing gastric and duodenal ulceration which may be probably due to its antioxidant and anti-acid secretory effects.

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“…According to Okayama’ method of modeling with some modifies [ 16 ], 32 Rats were equally and randomly divided into 4 groups: Control group, indomethacin group, PGP (0.253 g/kg) group, PGP (0.759 g/kg) group. After being adaptively fed for 5 days, the model of intestinal mucosal injury was replicated and administered.…”

Section: Methodsmentioning

confidence: 99%

Polysaccharides from Panax ginseng promote intestinal epithelial cell migration through affecting the Ca2+ related regulators

Zhu

Cao

Liang

et al. 2023

Journal of Ginseng Research

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Mast cells are involved in the pathogenesis of indomethacin-induced rat enteritis

Abstract: These results indicate that mast cells are involved in the pathogenesis of the intestinal mucosal damage induced by indomethacin.

Cited by 10 publications

References 26 publications

Glycomacropeptide Ameliorates Indomethacin-Induced Enteropathy in Rats by Modifying Intestinal Inflammation and Oxidative Stress

Glycomacropeptide Ameliorates Indomethacin-Induced Enteropathy in Rats by Modifying Intestinal Inflammation and Oxidative Stress

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Polysaccharides from Panax ginseng promote intestinal epithelial cell migration through affecting the Ca2+ related regulators

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