Mast Cells in Nonmammalian Vertebrates

Baccari, Gabriella Chieffi; Pinelli, Claudia; Santillo, Alessandra; Minucci, Sergio; Rastogi, Rakesh K.

doi:10.1016/b978-0-12-386037-8.00006-5

Cited by 57 publications

(66 citation statements)

References 204 publications

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“…MCs in different anatomical locations and in different species can vary in multiple aspects of phenotype, including their responsiveness to signals regulating their proliferation and function, their content of stored mediators, and their potential to produce various newly synthesized mediators [116, 117]. …”

Section: Tablementioning

confidence: 99%

New models for analyzing mast cell functions in vivo

Reber¹,

Marichal²,

Galli³

2012

Trends in Immunology

168

189

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In addition to their well-accepted role as critical effector cells in anaphylaxis and other acute IgE-mediated allergic reactions, mast cells have been implicated in a wide variety of process that contribute to disease or help to maintain health. While some of these roles were first suggested by analyses of mast cell products or functions in vitro, it is critical to determine whether, and under which circumstances, such potential roles actually can be performed by mast cells in vivo. This review discusses recent advances in the development and analysis of mouse models to investigate the roles of mast cells and mast cell-associated products during biological responses in vivo, and comments on some of the similarities and differences in the results obtained with these newer versus older models of mast cell deficiency.

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Section: Tablementioning

confidence: 99%

New models for analyzing mast cell functions in vivo

Reber¹,

Marichal²,

Galli³

2012

Trends in Immunology

168

189

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“…Mast cells are present in mammalian as well as nonmammalian [1] vertebrates in virtually all vascularized tissues. The first phase of research on mast cells was by von Recklinghausen [2] in 1863, who noticed granular cells in the mesentery of frogs, almost certainly the first observation of mast cells in any species.…”

Section: Introductionmentioning

confidence: 99%

The Staining of Mast Cells: A Historical Overview

Ribatti¹

2018

Int Arch Allergy Immunol

107

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The specificity of several staining methods for mast cells provides the pathologist with a useful means for the differential diagnosis of mast cell tumors. Mast cells stain metachromatically with toluidine blue with greater intensity in cells containing smaller granules. Most stains for mast cells rely on the cell’s content of heparin, other glycosaminoglycans, and esterase. As an alternative to histochemical stains, different antibodies have been used to identify mast cells in humans.

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“…The study of tilapia gill in situ by Barnett et al (1996) is the only one available that directly demonstrates EGC motility. EGCs are resident in many tissues including skin, intestinal epithelium, swim bladder and gill filament epidermis (Blackstock and Pickering 1980;Cross and Matthews 1991;Ezeasor and Stokoe 1980;Reite 1996;Reite and Evensen 1994;Powell et al 1990;Barnett et al 1996;Baccari et al 2011) consistent with a first line of defence function attributed to these cells. The present study utilized goldfish scale in situ and scale explants to provide the first detailed evaluation of epidermal EGC morphology and motility in a native or near-native environment.…”

Section: Discussionmentioning

confidence: 64%

Eosinophilic granule cells in Carassius auratus scale epidermis

DePasquale

2017

Acta Zoologica

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DePasquale, J.A. 2017. Eosinophilic granule cells in Carassius auratus scale epidermis. -Acta Zoologica (Stockholm) 98: 387-399.Eosinophilic granule cells (EGCs) were characterized in Carassius auratus scale epidermis in situ and in explants. Live EGCs were readily identified by the presence of numerous large cytoplasmic granules observed with DIC microscopy. Histochemical staining with toluidine blue and alcian blue yielded granule metachromasia and pale blue granules, respectively, both consistent with mammalian mast cell staining. However, EGCs also share some features with mammalian basophils as neutral red dye was selectively incorporated into EGC granules. EGCs within scale epidermis were actively motile, displaying average speeds of 16 lm/min and maximum speeds of greater than 40 lm/min and showing morphological plasticity during migration. The predominant motile phenotype was elongate with a well-developed leading lamella, while a broader body motile morphology was observed to a lesser extent. A trailing, relatively unchanged uropod was associated with every motile EGC and invariably contained one or a few granules. A rounded EGC shape without a leading-edge or trailing uropod was also observed and was generally associated with static cells. Individual cells readily switched between the three major shapes during motility; static cells could abruptly develop a polarized morphology, and actively motile cells switched between elongate and broad-bodied shapes or the static, rounded shape.EGCs in goldfish skin DePasquale Acta Zoologica (Stockholm) 98: 387-399 (October 2017)

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Mast Cells in Nonmammalian Vertebrates

Cited by 57 publications

References 204 publications

New models for analyzing mast cell functions in vivo

New models for analyzing mast cell functions in vivo

The Staining of Mast Cells: A Historical Overview

Eosinophilic granule cells in Carassius auratus scale epidermis

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