Mast cells in the eyes of Calomys callosus (Rodentia: Cricetidae) infected by Toxoplasma gondii

Gil, Cristiane Damas; Mineo, José Roberto; Smith, Ricardo Luiz; Oliani, Sônia Maria

doi:10.1007/s00436-002-0593-8

Cited by 14 publications

(9 citation statements)

References 19 publications

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“…Mast cells from these organs presented evident morphological alterations, indicating the presence of the degranulation process. Similar events were also seen after interaction between mast cells and T. gondii tachyzoites [11,12]. In addition, 48 h after T. gondii infection, C. callosus mast cells presented similar modifications to those seen in eutherian mammals under the effect of compound 48/80, a well-known degranulation agent [21].…”

Section: Discussionsupporting

confidence: 57%

“…These mediators promote infiltration of other leukocytes, including granulocytes, into the inflammatory loci. Although there are a number of in vitro and in vivo studies reporting the importance of mast cells in the defense against pathogens [10], few reports have demonstrated an interaction between mast cells and T. gondii, and the role of this interaction is not completely understood [3,11,12].…”

Section: Introductionmentioning

confidence: 99%

“…C. callosus, a wild mouse-like autochthonous rodent from South America, is a reservoir for various infectious agents [13]. This animal is highly susceptible to T. gondii infection, and it has been used as an appropriate alternative model to study experimental toxoplasmosis [12,[14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Toxoplasma gondii and mast cell interactions in vivo and in vitro: experimental infection approaches in Calomys callosus (Rodentia, Cricetidae)

Ferreira

Mineo

Oliveira

et al. 2004

Microbes and Infection

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Toxoplasma gondii and mast cell interactions in vivo and in vitro: experimental infection approaches in Calomys callosus (Rodentia, Cricetidae)

Ferreira

Mineo

Oliveira

et al. 2004

Microbes and Infection

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“…Furthermore, MC activation in the ocular tissues was observed after infection, suggesting that MCs play an important role in the acute inflammatory response against T. gondii (40). …”

Section: Mcs In T Gondii Infectionmentioning

confidence: 99%

The Roles of Mast Cells in Parasitic Protozoan Infections

Huang

2017

Front. Immunol.

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Protozoan parasites such as Plasmodium spp., Leishmania spp., Trypanosoma spp., and Toxoplasma gondii are major causes of parasitic diseases in both humans and animals. The immune system plays a critical role against protozoa, but their immune mechanism remains poorly understood. This highlights the need to investigate the function of immune cells involved in the process of parasite infections and the responses of host immune system to parasite infections. Mast cells (MCs) are known to be central players in allergy and anaphylaxis, and it has been demonstrated that MCs have crucial roles in host defense against a number of different pathogens, including parasites. To date, there are many studies that have examined the interaction of helminth-derived antigens and MCs. As one of the major effector cells, MCs also play an important role in the immune response against some parasitic protozoa, but their role in protozoan infections is, however, less well characterized. Herein, we review the current knowledge about the roles of MCs and their mediators during infections involving highly pathogenic protozoa including Plasmodium spp., Leishmania spp., Trypanosoma spp., and T. gondii. We offer a general review of the data from patients and experimental animal models infected with the aforementioned protozoa, which correlate MCs and MC-derived mediators with exacerbated inflammation and disease progression as well as protection against the parasitic infections in different circumstances. This review updates our current understanding of the roles of MCs during parasitic protozoan infections, and the participation of MCs in parasitic protozoan infections could be of a potential therapeutic target.

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“…In Group 1 (G1) the mice were infected intravitreally, according to Garweg et al (1998), with 10 6 promastigote forms of L. amazonensis; animals from G2 were instilled with 10 6 promastigote forms of L. amazonensis in one drop, according to Gil et al (2002); G3 was composed of non-infected control mice that received PBS pH 7.2 intravitreally and G4 was composed of non-infected control mice that were instilled with PBS pH 7.2. The same experimental design was used for BALB/c mice.…”

Section: Experimental Designmentioning

confidence: 99%

Ocular experimental leishmaniasis in C57BL/10 and BALB/c mice induced by Leishmania amazonensis infection

Calabrese

Silva

Hardoim

et al. 2013

Experimental Parasitology

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There are few studies on human ocular leishmaniasis found in the literature. The purpose of this study was to describe experimental ocular leishmaniasis, caused by Leishmania amazonensis evaluating two different infection routes: intravitreal and instillation in C57BL/10 and BALB/c mice. In this work all animals presented low anti-Leishmania IgM and IgG titers regardless of the infection route or mouse strain. The histopathological eye analysis showed that the mice inoculated by the intravitreal route developed more severe lesions, presenting parasites in the anterior region of the eye 60 days after infection. The C57BL/10 mice presented cells containing parasitophorous vacuoles associated with pigmented cells and inflammatory infiltrate, which included mast cells. Ninety days after infection no parasites could be found in either mouse strain, which led us to hypothesize that parasites had been eliminated. In this context, we show that both intravitreal and instillation routes were effective in promoting ocular leishmaniasis infections in C57BL/10 and BALB/c mice. There were no differences in the parasite infection between the two mouse models and it mimicked the ocular lesions described in symptomatic dogs in endemic areas of visceral leishmaniasis.

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Mast cells in the eyes of Calomys callosus (Rodentia: Cricetidae) infected by Toxoplasma gondii

Cited by 14 publications

References 19 publications

Toxoplasma gondii and mast cell interactions in vivo and in vitro: experimental infection approaches in Calomys callosus (Rodentia, Cricetidae)

Toxoplasma gondii and mast cell interactions in vivo and in vitro: experimental infection approaches in Calomys callosus (Rodentia, Cricetidae)

The Roles of Mast Cells in Parasitic Protozoan Infections

Ocular experimental leishmaniasis in C57BL/10 and BALB/c mice induced by Leishmania amazonensis infection

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