Maternal genotype influences behavioral development of 3×Tg-AD mouse pups

Blaney, Caitlin; Gunn, Rhian K.; Stover, Kurt R.; Brown, Richard E.

doi:10.1016/j.bbr.2013.05.033

Cited by 21 publications

(17 citation statements)

References 92 publications

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“…Mouse pups often fall on their back and then right themselves onto all four feet, and we measured how much time it takes to right themselves. Consistent with previous studies [20,21], the righting reflex latency decreased between 23.75 dpc and 25.75 dpc in full-term pups (Figure 4D), indicating that motor performance of pups develops during this period. Interestingly, we found no significant difference in the righting reflex latency between full-term pups and preterm pups (Figure 4D), suggesting that the improvement of motor performance after birth is irrelevant to when pups are born.…”

Section: Resultssupporting

confidence: 92%

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The development of suckling behavior of neonatal mice is regulated by birth

Toda

Kawasaki

2014

Molecular Brain

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BackgroundAlthough the function of the sensory system rapidly develops soon after birth in newborn pups, little is known about the mechanisms triggering this functional development of the sensory system.ResultsHere we show that the birth of pups plays an active role in the functional development of the sensory system. We first optimized the experimental procedure for suckling behavior using neonatal mouse pups. Using this procedure, we found that preterm birth selectively accelerated the development of suckling behavior in neonatal pups, but not that of motor performance, suggesting that the birth of pups regulates the functional development of the sensory system soon after birth.ConclusionsTaken together with our recent findings that birth itself regulates the initiation of sensory map formation in the somatosensory and visual systems, these results support the idea that the birth of pups actively regulates the anatomical and functional development of the sensory system.

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Section: Resultssupporting

confidence: 92%

“…Mouse pups often fall on their back and then right themselves onto all four feet, and we measured how much time it took to right themselves onto all four feet as described previously [20,21]. …”

Section: Methodsmentioning

confidence: 99%

The development of suckling behavior of neonatal mice is regulated by birth

Toda

Kawasaki

2014

Molecular Brain

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“…It is possible that the low number of males tested at 9-months of age prevented us from detecting the same effect due to high variability. Overall, the results suggest that much remains to be discovered about sex differences in the development, progression and treatment of AD-like symptoms in mouse models of AD [42,[50][51][52].…”

Section: Discussionmentioning

confidence: 88%

Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study

Stevens

Brown

2015

Behavioural Brain Research

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“…While there is extensive evidence of maternal genotype effect on pups body weight [59, 60], retrieval [61, 62], postnatal care and pups ultrasonic vocalization [62, 63], as well as adult behaviour, including response to stress and anxiety levels [59, 64], most of these results used cross-fostering pups between genetically different mothers. In our case, we observed the differences in the body weight of adult, but not pre-weanling, mice between reciprocal breeding paradigms of FVB/NCrL and 129S2/SvPasCrL mice.…”

Section: Discussionmentioning

confidence: 99%

The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice

Janus

Golde

2014

Behavioural Brain Research

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Deep hypothermia (cryoanesthesia) is often used as general anesthesia during surgery in neonatal rodents. Neonatal cryoanesthesia has been used recently to generate somatic brain transgenic (SBT) mouse models via intracerebral ventricular injection of rAAV vectors into both non-transgenic mice and numerous transgenic mouse models. Since, the evaluation of cognition is one of the main experimental endpoints in many of these studies, we examined the consequences of brief neonatal cryoanesthesia on the physical development and mnemonic function of adult mice. Two groups of 129FVBF1 pups from reciprocal breeding crosses underwent cryoanesthesia for 6 (Cryo6) or 12 (Cryo12) min, respectively, within the first hours (< 12hr) of postnatal life. A group of pups separated from the nest and kept in ambient temperature of 33 °C for 6 min served as a control. Our results revealed that lowering the temperature of pups to ~8 °C (Cryo6) or ~5 °C (Cryo12) did not affect their body weight at pre-weaning stage and in the adulthood. The evaluation of cognitive function in adult mice revealed strong and comparable to controls spatial reference, and context and tone fear memories of neonatally cryoanesthetized mice. Also, the experimental and control groups had comparable brain weight at the end of the study. Our results demonstrate that neonatal cryoanesthesia, lasting up to 12 min, has no adverse effects on the body weight of mice during development, and on their cognition in the adulthood.

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Maternal genotype influences behavioral development of 3×Tg-AD mouse pups

Cited by 21 publications

References 92 publications

The development of suckling behavior of neonatal mice is regulated by birth

The development of suckling behavior of neonatal mice is regulated by birth

Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study

The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice

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