Maternal Immune Activation and Neuropsychiatric Disorders: The Intricate Puzzle of Autism Spectrum Disorder

Fontes-Dutra, Mellanie; Rabelo, Bruna; Santos-Terra, Júlio; Deckmann, Iohanna; Schwingel, Gustavo Brum; Gottfried, Carmem

doi:10.1007/978-3-030-39335-9_11

Cited by 3 publications

(2 citation statements)

References 213 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maternal immune activation (MIA) is associated with the onset of disorders such as ASD and schizophrenia (Fontes‐Dutra et al, 2020). MIA induction by poly(I:C) exposure enhanced PAX6 (paired box 6) expression in mice embryos resulting in cell cycle impairments and increased number of cortical neurons expressing COUP‐TF interacting protein 2 (CTIP2) in deeper layers (V and VI) (Ben‐Reuven & Reiner, 2019).…”

Section: Environmental Factors and Tfs In Psychiatric Disordersmentioning

confidence: 99%

Transcription factors in neurodevelopmental and associated psychiatric disorders: A potential convergence for genetic and environmental risk factors

Santos-Terra

Deckmann

Fontes-Dutra

et al. 2021

Intl J of Devlp Neuroscience

Self Cite

View full text Add to dashboard Cite

Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of psychiatric conditions marked by impairments in the nervous system. Their onset occurs during gestation, and the alterations are observed throughout the postnatal life. Although many genetic and environmental risk factors have been described in this context, the interactions between them challenge the understanding of the pathways associated with NDDs. Transcription factors (TFs)—a group of over 1,600 proteins that can interact with DNA, regulating gene expression through modulation of RNA synthesis—represent a point of convergence for different risk factors. In addition, TFs organize critical processes like angiogenesis, blood‐brain barrier formation, myelination, neuronal migration, immune activation, and many others in a time and location‐dependent way. In this review, we summarize important TF alterations in NDD and associated disorders, along with specific impairments observed in animal models, and, finally, establish hypotheses to explain how these proteins may be critical mediators in the context of genome‐environment interactions.

show abstract

Section: Environmental Factors and Tfs In Psychiatric Disordersmentioning

confidence: 99%

Transcription factors in neurodevelopmental and associated psychiatric disorders: A potential convergence for genetic and environmental risk factors

Santos-Terra

Deckmann

Fontes-Dutra

et al. 2021

Intl J of Devlp Neuroscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, maternal immune activation (MIA) induces ASD-like features, changes in the cytokine profile (especially IL-6), and imbalances in lymphocyte populations [30,31]. In addition, it is observed to alter the expression of genes associated with neurodevelopment, such as genes involved with migration, function, and placement of interneurons [32][33][34]. Similarly, prenatal exposure to valproic acid (VPA) in rodents, a well-established model of autism [35][36][37][38][39], induces interneuronal alterations in sensory areas [36] and HC [40,41].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Prevents Cytoarchitectural and Interneuronal Alterations in the Valproic Acid Rat Model of Autism

Santos-Terra

Deckmann

Carello‐Collar

et al. 2022

IJMS

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by several alterations, including disorganized brain cytoarchitecture and excitatory/inhibitory (E/I) imbalance. We aimed to analyze aspects associated with the inhibitory components in ASD, using bioinformatics to develop notions about embryonic life and tissue analysis for postnatal life. We analyzed microarray and RNAseq datasets of embryos from different ASD models, demonstrating that regions involved in neuronal development are affected. We evaluated the effect of prenatal treatment with resveratrol (RSV) on the neuronal organization and quantity of parvalbumin-positive (PV+), somatostatin-positive (SOM+), and calbindin-positive (CB+) GABAergic interneurons, besides the levels of synaptic proteins and GABA receptors in the medial prefrontal cortex (mPFC) and hippocampus (HC) of the ASD model induced by valproic acid (VPA). VPA increased the total number of neurons in the mPFC, while it reduced the number of SOM+ neurons, as well as the proportion of SOM+, PV+, and CB+ neurons (subregion-specific manner), with preventive effects of RSV. In summary, metabolic alterations or gene expression impairments could be induced by VPA, leading to extensive damage in the late developmental stages. By contrast, due to its antioxidant, neuroprotective, and opposite action on histone properties, RSV may avoid damages induced by VPA.

show abstract

Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid

Schwingel,

Fontes-Dutra,

Ramos

et al. 2023

IBRO Neuroscience Reports

View full text Add to dashboard Cite

Maternal Immune Activation and Neuropsychiatric Disorders: The Intricate Puzzle of Autism Spectrum Disorder

Cited by 3 publications

References 213 publications

Transcription factors in neurodevelopmental and associated psychiatric disorders: A potential convergence for genetic and environmental risk factors

Transcription factors in neurodevelopmental and associated psychiatric disorders: A potential convergence for genetic and environmental risk factors

Resveratrol Prevents Cytoarchitectural and Interneuronal Alterations in the Valproic Acid Rat Model of Autism

Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid

Contact Info

Product

Resources

About