Maternal long chain polyunsaturated fatty acid status and pregnancy complications

Wadhwani, Nisha; Patil, Vidya; Joshi, Sadhana

doi:10.1016/j.plefa.2017.08.002

Cited by 37 publications

(24 citation statements)

References 185 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the dietary shifts over the years towards a Western diet has caused a drastic change in the ratio of Omega-6 to Omega-3 fatty ac- *p-value for measures ANOVA performed to assess variations in energy and macronutrient intakes between groups; group P1 -GDM patients; group P2 -T1DM patients; group P3 -normal pregnancy patients; SFA -saturated fatty acids; MUFA -monounsaturated fatty acids; PUFA -polyunsaturated fatty acids; EPA -eicosapentaenoic acid; DHA -docosahexaenoic acid ids from 1:1 to 20-30:1 [25]. This transition in the Omega-6 to Omega-3 fatty acid ratio may influence placental development and promote the pathogenesis of several chronic diseases [13,26]. Many international scientific societies, including the Polish Gynaecological Society, recommend the use of 600 mg of DHA daily for the prevention of premature labor [27].…”

Section: Discussionmentioning

confidence: 99%

“…In our study more than 75% of all patients consumed less DHA than the amount recommended. Assessments of dietary intakes in various populations suggest that pregnant women have difficulty meeting all their DHA requirements through diet alone [13]. Harton et al showed in their study involving 30 Polish women during the third trimester of pregnancy, that less DHA was used than recommended [28].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, abnormal placental transport function in GDM is known to further disturb the materno-fetal transport of LCPUFA which may further result in potential adverse consequences for neurodevelopment and adiposity risks for the offspring [12]. In view of the fact that non communicable diseases in adulthood are influenced by nutritional programming, it is essential for women to maintain optimal levels of LCPUFA during pregnancy, and the balanced ratio of Omega-6 to Omega-3 fatty acids in the diet is known to have especially important metabolic implications [13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dietary macronutrients and fluid intakes in a sample of pregnant women with either gestational diabetes or type 1 diabetes mellitus, assessed in comparison with Polish nutritional guidelines

et al. 2018

View full text Add to dashboard Cite

Objectives: Pregnancy is a critical period during which environmental factors such as nutrition can affect development. Maintaining proper nutrition becomes even more significant when pregnant women have diabetes. The aim of this study was to measure changes in energy and macronutrient intakes among pregnant women and patients diagnosed either with gestational diabetes mellitus (GDM) during pregnancy, or, type 1 diabetes mellitus (T1DM) before pregnancy, and to assess the pregnant women's dietary intakes in comparison with Polish Institute of Food and Nutrition nutritional guidelines. Material and methods: The analysis was conducted among 83 pregnant women (29 GDM patients, 26 T1DM patients and 28 normal pregnancy patients-the control group) from whom we gathered nutritional data during the second part of their pregnancies. Data on each woman's diet during pregnancy was collected is self-completed dietary records during seven consecutive 24-hour periods. Results: The mean macronutrient intake of the GDM patients was 32.1% fat, 19.5% protein, and 48.3% carbohydrates; in the T1DM group the results were 34.2%, 19.4% and 46.4% respectively; and in control group they were 31.8%, 17.6% and 50.5% respectively. This study showed that many of the pregnant women did not reach the recommended level of energy intake during pregnancy. Moreover, most of the women exceeded their fat requirements, and fat intake as a proportion of energy intakes also exceeded the guidelines in more than 60% of the women across all groups. Conclusions: The implications and possible causes of excessive fat intake during pregnancy and pregnancies complicated by diabetes are underestimated and undertreated by obstetricians and warrant further investigation, especially in association with gestational weight gain, maternal and fetal perinatal complications, and post-gestational diabetes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary macronutrients and fluid intakes in a sample of pregnant women with either gestational diabetes or type 1 diabetes mellitus, assessed in comparison with Polish nutritional guidelines

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Most of these abnormalities are observed in cloned pig fetuses or newborn piglets (Ao, Li, et al, ; Carroll, Carter, Korte, & Prather, ; Cho et al, ; Estrada et al, ). Substantial epidemiological and experimental evidence demonstrates that fetal fatty acid deficiency has long‐term implications for the development of metabolic diseases in postnatal life (Haggarty, ; Innis, ; Wadhwani, Patil, & Joshi, ). Thus, fatty acid deficiency may be a potential cause of high perinatal morbidity and mortality in cloned pig fetuses and newborn piglets.…”

Section: Discussionmentioning

confidence: 99%

Cloned pig fetuses exhibit fatty acid deficiency from impaired placental transport

Zhou

et al. 2019

Molecular Reproduction Devel

View full text Add to dashboard Cite

Cloned pig fetuses produced by somatic cell nuclear transfer show a high incidence of erroneous development in the uteri of surrogate mothers. The mechanisms underlying the abnormal intrauterine development of cloned pig fetuses are poorly understood. This study aimed to explore the potential causes of the aberrant development of cloned pig fetuses. The levels of numerous fatty acids in allantoic ﬂuid and muscle tissue were lower in cloned pig fetuses than in artificial insemination‐generated pig fetuses, thereby suggesting that cloned pig fetuses underwent fatty acid deficiency. Cloned pig fetuses also displayed trophoblast hypoplasia and a reduced expression of placental fatty acid transport protein 4 (FATP4), which is the predominant FATP family member expressed in porcine placentas. This result suggested that the placental fatty acid transport functions were impaired in cloned pig fetuses, possibly causing fatty acid deficiency in cloned pig fetuses. The present study provides useful information in elucidating the mechanisms underlying the abnormal development of cloned pig fetuses.

show abstract

“…Based on the available evidence, changes in long-chain PUFA, mainly n-6 and n-3 fatty acids, are associated with GDM and pregnancies complicated by pre-eclampsia and intra-uterine growth restriction (6) . A meta-analysis by Saccone et al (7) indicated that n-3 fatty acid supplementation in pregnant women decreased C-reactive protein (CRP) levels and improved some pregnancy outcomes such as newborn's hyperbilirubinemia and hospitalisation rate.…”

mentioning

confidence: 99%

The effects ofn-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomised, double-blind, placebo-controlled trial

et al. 2020

View full text Add to dashboard Cite

The present study was performed to evaluate the effects of n-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus (GDM). This randomised, double-blind, placebo-controlled clinical trial was performed in sixty women with GDM. Participants were randomly divided into two groups to intake either 2 × 1000 mg/d n-3 fatty acids from flaxseed oil containing 400 mg α-linolenic acid in each capsule (n 30) or placebo (n 30) for 6 weeks. n-3 Fatty acid intake up-regulated PPAR-γ (P < 0·001) and LDL receptor (P = 0·004) and down-regulated gene expression of IL-1 (P = 0·002) and TNF-α (P = 0·001) in peripheral blood mononuclear cells of subjects with GDM. In addition, n-3 fatty acid supplementation reduced fasting plasma glucose (P = 0·001), insulin levels (P = 0·001) and insulin resistance (P < 0·001) and increased insulin sensitivity (P = 0·005) when compared with the placebo. Additionally, n-3 fatty acid supplementation was associated with a decrease in TAG (P < 0·001), VLDL-cholesterol (P < 0·001), total cholesterol (P = 0·01) and total cholesterol:HDL-cholesterol ratio (P = 0·01) when compared with placebo. n-3 Fatty acid administration was also associated with a significant reduction in high-sensitivity C-reactive protein (P = 0·006) and malondialdehyde (P < 0·001), and an increase in total nitrite (P < 0·001) and total glutathione levels (P = 0·006) when compared with the placebo. n-3 Fatty acid supplementation for 6 weeks to women with GDM had beneficial effects on gene expression related to insulin, lipid and inflammation, glycaemic control, lipids, inflammatory markers and oxidative stress.

show abstract

Maternal long chain polyunsaturated fatty acid status and pregnancy complications

Cited by 37 publications

References 185 publications

Dietary macronutrients and fluid intakes in a sample of pregnant women with either gestational diabetes or type 1 diabetes mellitus, assessed in comparison with Polish nutritional guidelines

Dietary macronutrients and fluid intakes in a sample of pregnant women with either gestational diabetes or type 1 diabetes mellitus, assessed in comparison with Polish nutritional guidelines

Cloned pig fetuses exhibit fatty acid deficiency from impaired placental transport

The effects ofn-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomised, double-blind, placebo-controlled trial

Contact Info

Product

Resources

About