Maternal nicotine exposure during gestation and lactation induces kidney injury and fibrosis in rat offspring

Chen, Chung-Ming; Chou, Hsiu Chu; Huang, Liang

doi:10.1038/pr.2014.148

Cited by 26 publications

(25 citation statements)

References 39 publications

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“…While there was high nicotine exposure as evidenced by the increased cotinine levels, the amount of other toxins in the condensate may have been less than in our model. A more recent study also found that smoke exposure in utero has pro-fibrotic influences on offspring kidneys (Chen et al, 2015). Although we did not detect any renal histological changes at any time point (data not shown) nor an increase in serum creatinine, we propose that our findings of mitochondrial alterations at birth and adulthood may put offspring at increased risk for renal pathology especially in the setting of additional insults, such as sepsis or toxins.…”

Section: Discussioncontrasting

confidence: 41%

Oxidative stress, mitochondrial perturbations and fetal programming of renal disease induced by maternal smoking

Stangenberg

Nguyen

Chen

et al. 2015

The International Journal of Biochemistry & Cell Biology

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An adverse in-utero environment is increasingly recognized to predispose to chronic disease in adulthood. Maternal smoking remains the most common modifiable adverse in-utero exposure leading to low birth weight, which is strongly associated with chronic kidney disease (CKD) in later life. In order to investigate underlying mechanisms for such susceptibility, female Balb/c mice were sham or cigarette smoke-exposed (SE) for 6 weeks before mating, throughout gestation and lactation. Offspring kidneys were examined for oxidative stress, expression of mitochondrial proteins, mitochondrial structure as well as renal functional parameters on postnatal day 1, day 20 (weaning) and week 13 (adult age). From birth throughout adulthood, SE offspring had increased renal levels of mitochondrial-derived reactive oxygen species (ROS), which left a footprint on DNA with increased 8-hydroxydeoxyguanosin (8-OHdG) in kidney tubular cells. Mitochondrial structural abnormalities were seen in SE kidneys at day 1 and week 13 along with a reduction in oxidative phosphorylation (OXPHOS) proteins and activity of mitochondrial antioxidant Manganese superoxide dismutase (MnSOD). Smoke exposure also resulted in increased mitochondrial DNA copy number (day 1-week 13) and lysosome density (day 1 and week 13). The appearance of mitochondrial defects preceded the onset of albuminuria at week 13. Thus, mitochondrial damage caused by maternal smoking may play an important role in development of CKD at adult life.

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Section: Discussioncontrasting

confidence: 41%

Oxidative stress, mitochondrial perturbations and fetal programming of renal disease induced by maternal smoking

Stangenberg

Nguyen

Chen

et al. 2015

The International Journal of Biochemistry & Cell Biology

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“…In the present studies, due to potential differences in susceptibility of adverse in utero conditions between each sibling within a litter, individual offspring were used as an experimental unit (Chen et al 2015; Ngo et al 2014). Effects on birth weights, litter size, organ weights, area under the curve, hormone concentrations, differences in mRNA expression, and open arm entries in the EPM were analyzed using a one-way ANOVA with Proc GLM in SAS (version 9.2; SAS Institute, Cary, NC, USA).…”

Section: Methodsmentioning

confidence: 99%

Effects of Periconception Cadmium and Mercury Co-Administration to Mice on Indices of Chronic Diseases in Male Offspring at Maturity

Çamsarı

Folger

McGee

et al. 2017

Environ Health Perspect

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Background:Long-term exposure to the heavy metals cadmium (Cd) and mercury (Hg) is known to increase the risk of chronic diseases. However, to our knowledge, exposure to Cd and Hg beginning at the periconception period has not been studied to date.Objective:We examined the effect of Cd and Hg that were co-administered during early development on indices of chronic diseases in adult male mice.Methods:Adult female CD1 mice were subcutaneously administered a combination of cadmium chloride (CdCl2) and methylmercury (II) chloride (CH3HgCl) (0, 0.125, 0.5, or 2.0 mg/kg body weight each) 4 days before and 4 days after conception (8 days total). Indices of anxiety-like behavior, glucose homeostasis, endocrine and molecular markers of insulin resistance, and organ weights were examined in adult male offspring.Results:Increased anxiety-like behavior, impaired glucose homeostasis, and higher body weight and abdominal adipose tissue weight were observed in male offspring of treated females compared with controls. Significantly increased serum leptin and insulin concentrations and impaired insulin tolerance in the male offspring of dams treated with 2.0 mg/kg body weight of Cd and Hg suggested insulin resistance. Altered mRNA abundance for genes associated with glucose and lipid homeostasis (GLUT4, IRS1, FASN, ACACA, FATP2, CD36, and G6PC) in liver and abdominal adipose tissues as well as increased IRS1 phosphorylation in liver (Ser 307) provided further evidence of insulin resistance.Conclusions:Results suggest that the co-administration of Cd and Hg to female mice during the early development of their offspring (the periconception period) was associated with anxiety-like behavior, altered glucose metabolism, and insulin resistance in male offspring at adulthood.Citation:Camsari C, Folger JK, McGee D, Bursian SJ, Wang H, Knott JG, Smith GW. 2017. Effects of periconception cadmium and mercury co-administration to mice on indices of chronic diseases in male offspring at maturity. Environ Health Perspect 125:643–650; http://dx.doi.org/10.1289/EHP481

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“…All these observations point out that chronic profibrotic or vascular effects rather than immunological effects might play a role in previous smokers. In rats, nicotine stimulates the epithelial–mesenchymal transition (EMT) and connective tissue growth factor (CTGF) expression in kidney epithelium and induces neonatal kidney fibrosis after exposure to pregnant animals . In line with this, despite comparable kidney function, native kidney biopsies of current or historical smokers show a higher degree of glomerulosclerosis and arteriolar hyalinosis than in people who never smoked .…”

Section: Discussionmentioning

confidence: 84%

“…In mice, chronic nicotine exposure potentiates acute kidney injury by potentiating ischaemia/reperfusion‐related oxidative stress . Other proposed mechanisms include stimulation of renal nicotinic acetylcholine receptors and the renin–angiotensin system, increased sympathetic activity and finally direct hemodynamic effects leading to reduced glomerular filtration rate and renal plasma flow .…”

Section: Introductionmentioning

confidence: 99%

Former smoking and early and long-term graft outcome in renal transplant recipients: a retrospective cohort study

et al. 2017

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Smoking is associated with unfavourable outcome in solid-organ transplant recipients. Nicotine may predispose to kidney injury by increasing oxidative stress. We hypothesized that former smoking negatively affects graft outcome in kidney transplant recipients and especially those with delayed graft function (DGF). We included adult recipients of a kidney transplant between 1 January 2003 and 1 October 2015 at Ghent University Hospital and recorded outcomes until 31 October 2015. We used Kaplan-Meier and multivariable Cox proportional hazard analysis to examine the relationship between former smoking at the time of transplantation and the incidence of 10-year graft loss with and without censoring for death in 1013 participants. We evaluated mean differences in eGFR over time by a random intercept and slope model, considering a linear time effect. After adjusting for potential confounders, a history of smoking was associated with an increased hazard of graft loss (adjusted hazard ratio (aHR) 1.60; 95% CI: 1.17-2.17; P = 0.003) and death-censored graft loss (aHR 2.29; 95% CI: 1.41-3.72; P = 0.001). The linear time trend of eGFR was different between former and never smokers (P = 0.001). To conclude, former smoking exerts long-lasting negative effects on graft outcome and this independent of DGF.

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Maternal nicotine exposure during gestation and lactation induces kidney injury and fibrosis in rat offspring

Cited by 26 publications

References 39 publications

Oxidative stress, mitochondrial perturbations and fetal programming of renal disease induced by maternal smoking

Oxidative stress, mitochondrial perturbations and fetal programming of renal disease induced by maternal smoking

Effects of Periconception Cadmium and Mercury Co-Administration to Mice on Indices of Chronic Diseases in Male Offspring at Maturity

Former smoking and early and long-term graft outcome in renal transplant recipients: a retrospective cohort study

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