Maternal obesity increases the risk of fetal cardiac dysfunction via visceral adipose tissue derived exosomes

Liu, Yunnan; Wang, Yixiao; Wang, Chen; Shi, Ruijing; Zhou, Xueying; Li, Zhelong; Sun, Wenqi; Zhao, Lianbi; Yuan, Lijun

doi:10.1016/j.placenta.2021.01.020

Cited by 18 publications

(13 citation statements)

References 35 publications

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“…The study has established an exosomal pathway how obesity aggravates colitis, which well explained the strong association of obesity with the risk of colitis found in epidemic studies (Wei et al, 2020). We have also found that exosomes from the maternal adipose tissue could cross the placenta barrier, affecting the developmental embryos (Liu et al, 2021).…”

Section: Adipose Tissue-derived Exosomes In Regulation Of Other Systemssupporting

confidence: 57%

“…ASCs-Exos can optimize the characteristics of fibroblasts to achieve the purpose of promoting skin wound healing (Hu et al, 2016;Zhang W. et al, 2018) and improve erectile dysfunction in diabetic mice (Chen F. et al, 2017). Similarly, overexpression of miR-19b in VAT exosomes can reduce inflammation in placental cells (Liu et al, 2021). With the continuous deepening of related research, exosomes from adipose tissue or adipocytes or the precursor, are expected to widely used in different diseases.…”

Section: Other Diagnostic and Therapeutic Implications Of Adipose Tismentioning

confidence: 99%

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Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions

et al. 2021

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Adipose tissue functions importantly in the bodily homeostasis and systemic metabolism, while obesity links to multiple disorders. Beyond the canonical hormones, growth factors and cytokines, exosomes have been identified to play important roles in transmission of information from adipose tissue to other organs. Exosomes are nanoscale membrane vesicles secreted by donor cells, and transfer the genetic information to the recipient cells where the encapsulated nucleic acids and proteins are released. In this review, we elaborate the recent advances in the biogenesis and profiling of adipose tissue derived exosomes, and their physiological and pathological effects on different organs. Moreover, the potential significance of the exosomes as therapeutic vehicles or drugs is also discussed.

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Section: Adipose Tissue-derived Exosomes In Regulation Of Other Systemssupporting

confidence: 57%

Section: Other Diagnostic and Therapeutic Implications Of Adipose Tismentioning

confidence: 99%

Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions

et al. 2021

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“…For instance, an increased level of lncRNA-NBR2 in exosomes may lead to heart muscle collagen deposition and decreased cardiac function. Moreover, the obese pregnant mice model suggests that placenta inflammation and fetal cardiac dysfunction may be associated with decreased miRNA-19b in VAT-derived exosomes [ 68 ]. Animal models also suggest that perivascular adipose tissue-derived exosomes promote the migration of vascular smooth muscle cells (VSMC) and lead to diabetes-induced vascular dysfunction [ 69 ].…”

Section: The Role Of Adipose Tissue-derived Exosomes In Obesity and Insulin Resistancementioning

confidence: 99%

Adipose-Derived Exosomes as Possible Players in the Development of Insulin Resistance

Żbikowski

Błachnio-Zabielska

Galli

2021

IJMS

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Adipose tissue (AT) is an endocrine organ involved in the management of energy metabolism via secretion of adipokines, hormones, and recently described secretory microvesicles, i.e., exosomes. Exosomes are rich in possible biologically active factors such as proteins, lipids, and RNA. The secretory function of adipose tissue is affected by pathological processes. One of the most important of these is obesity, which triggers adipose tissue inflammation and adversely affects the release of beneficial adipokines. Both processes may lead to further AT dysfunction, contributing to changes in whole-body metabolism and, subsequently, to insulin resistance. According to recent data, changes within the production, release, and content of exosomes produced by AT may be essential to understand the role of adipose tissue in the development of metabolic disorders. In this review, we summarize actual knowledge about the possible role of AT-derived exosomes in the development of insulin resistance, highlighting methodological challenges and potential gains resulting from exosome studies.

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“… 217 , 218 , 219 Importance of exosomes in cardiometabolic diseases is emphasized in a recent study showing that visceral adipose exosomes in pregnant obese mice contribute to fetal cardiac dysfunction. 220 Interestingly, exosomes secreted from adipocytes in response to ER stress induce steatosis, inflammation, and fibrosis in the liver and lead to NASH through the alteration of hepatic lipid dynamics. 221 Also, it has recently been shown that intestinal exosomes released from high‐fat diet fed mice or T2D patients can induce insulin resistance in normal mice.…”

Section: Nsmase2 Biochemistry and Regulationmentioning

confidence: 99%

Neutral sphingomyelinase‐2 and cardiometabolic diseases

et al. 2021

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Sphingolipids, in particular ceramides, play vital role in pathophysiological processes linked to metabolic syndrome, with implications in the development of insulin resistance, pancreatic ß-cell dysfunction, type 2 diabetes, atherosclerosis, inflammation, nonalcoholic steatohepatitis, and cancer. Ceramides are produced by the hydrolysis of sphingomyelin, catalyzed by different sphingomyelinases, including neutral sphingomyelinase 2 (nSMase2), whose dysregulation appears to underlie many of the inflammation-related pathologies. In this review, we discuss the current knowledge on the biochemistry of nSMase2 and ceramide production and its regulation by inflammatory cytokines, with particular reference to cardiometabolic diseases. nSMase2 contribution to pathogenic processes appears to involve cyclical feedforward interaction with proinflammatory cytokines, such as TNF-α and IL-1ß, which activate nSMase2 and the production of ceramides, that in turn triggers the synthesis and release of inflammatory cytokines. We elaborate these pathogenic interactions at the molecular level and discuss the potential therapeutic benefits of inhibiting nSMase2 against inflammation-driven cardiometabolic diseases.

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Maternal obesity increases the risk of fetal cardiac dysfunction via visceral adipose tissue derived exosomes

Cited by 18 publications

References 35 publications

Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions

Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions

Adipose-Derived Exosomes as Possible Players in the Development of Insulin Resistance

Neutral sphingomyelinase‐2 and cardiometabolic diseases

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