Maternal Serum Level of Adiponectin and Macroscopic Changes of Placentae in Preeclampsia

Abstract

The objective of the present study was to measure the serum level of adiponectin in preeclamptic Egyptian pregnant women and find the possible correlations of maternal adiponectin level to measured insulin resistance in such case and to macroscopic features of placentae included in this study.The study population consisted of 30 preeclamptic patients and 30 matched healthy pregnant women during the third trimester.The results revealed that preeclamptic women were more insulin resistant with a significant decrease in adiponectin level compared with healthy controls. Correlation analysis presented a significant negative correlation between adiponectin levels and measured insulin resistance among preeclamptic women. Pregnant women with preeclampsia had lower placental weight and decreased number of cotyledons with marginal insertion of umbilical cord. The present study did not show any correlations between adiponectin levels versus macroscopic features of placentae among preeclamptic mothers.It can be concluded that preeclamptic mothers are more insulin resistant, which was reflected through increased HOMA-IR value; this relationship postulates that insulin resistance may be one of the casual pathways of preeclampsia. Hypoadiponectinemia may be one of the possible etiologies of preeclampsia. Preeclamptic placentae exhibited definite morphological changes which may be attributed to the vascular insufficiency of placenta.

Study of Visfatin Level and Its Relation to Some Histopathological Changes of Placentae in Preeclampsia

“…Other adipocyte products such as adiponectin, and interleukin-10 exert an antiatherogenic effect [45] . The results of our previous study revealed that preeclamptic women were more insulin resistant with a significant decrease in adiponectin level compared with healthy controls [46] . This was also in accordance with published data showing that body mass index is only related to visfatin in men, but not in women [47] .…”

Rising plasminogen activator inhibitor-1 and hypoadiponectinemia characterize the cardiometabolic biomarker profile of women with recent gestational diabetes

“…Taken together with the current demonstration that women with recent GDM have low adiponectin at both 1- and 3-years after delivery, these data collectively suggest that hypoadiponectinemia is a chronic feature of this patient population before, during, and after pregnancy. Moreover, a higher leptin/adiponectin ratio in women with GDM has been associated with an unfavourable cardiovascular risk factor profile on postpartum follow-up [ 28 ] and hypoadiponectinemia in pregnancy has been suggested as a possible factor contributing to preeclampsia, which is also associated with future risk of CVD [ 29 ].…”