No abstract

The objective of the present study was to measure the serum level of adiponectin in preeclamptic Egyptian pregnant women and find the possible correlations of maternal adiponectin level to measured insulin resistance in such case and to macroscopic features of placentae included in this study.The study population consisted of 30 preeclamptic patients and 30 matched healthy pregnant women during the third trimester.The results revealed that preeclamptic women were more insulin resistant with a significant decrease in adiponectin level compared with healthy controls. Correlation analysis presented a significant negative correlation between adiponectin levels and measured insulin resistance among preeclamptic women. Pregnant women with preeclampsia had lower placental weight and decreased number of cotyledons with marginal insertion of umbilical cord. The present study did not show any correlations between adiponectin levels versus macroscopic features of placentae among preeclamptic mothers.It can be concluded that preeclamptic mothers are more insulin resistant, which was reflected through increased HOMA-IR value; this relationship postulates that insulin resistance may be one of the casual pathways of preeclampsia. Hypoadiponectinemia may be one of the possible etiologies of preeclampsia. Preeclamptic placentae exhibited definite morphological changes which may be attributed to the vascular insufficiency of placenta.

The objective of the present study was to measure the serum level of visfatin in preeclamptic Egyptian pregnant women and the possible relation of visfatin level to each of the measured insulin resistance, body mass index and histopathological changes of the placenta included in this study.The study population consisted of 30 preeclamptic patients and 30 matched healthy pregnant women during the third trimester.The present study results revealed that preeclamptic mothers had a significant increase in insulin resistance value than normal pregnant women with no significant difference in this value between mild and severe preeclamptic sub-groups. Regarding visfatin level, there was a highly significant increase in visfatin level in preeclamptic women compared with healthy controls and also increase in severe than mild preeclamptic sub-groups. Correlation analysis presented a significant negative correlation between maternal visfatin levels versus HOMA-IR among preeclamptic group, but no relation had been found between visfatin levels and body mass index among preeclamptic mothers. Histopathological examination of placentae revealed that infarctions, atherosis, hyalinized areas and Tenny Parkers changes were significantly increased in preeclamptic group than control group. The present study did not find any correlations between visfatin levels versus histopathological changes in placentae among preeclamptic mothers.Hypervisfatinemia may be one of the possible etiologies of preeclampsia. Visfatin might be part of a feedback mechanism improving insulin sensitivity. Preeclamptic placentae exhibited definite histopathological changes which may be attributed to the vascular insufficiency of placenta.