Maternal Serum Levels of Zinc, Copper, and Thiols in Preeclampsia Patients: a Case-Control Study

Gül, Ayşe; Atakul, Nil; Selek, Sahabettın; Atamer, Yıldız; Sarıkaya, Ufuk; Yıldız, Tugce; Demirel, Metin

doi:10.1007/s12011-021-02660-y

Cited by 11 publications

(13 citation statements)

References 37 publications

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“…1 a). The vast majority of included studies were designed as case–control ( n = 23) with some ( n = 4) cohort studies [ 3 , 5 – 7 , 11 , 13 – 23 , 26 ]. The studies included ( n = 9) in the meta-analyses reported that controls and women with preeclampsia were matched for maternal age.…”

Section: Resultsmentioning

confidence: 99%

“…Mode of delivery was seldom reported in included studies, whereas gestational age at sampling is included in Table 1 . Although the majority of studies ( n = 24) measured biomarkers in blood or blood-derived samples [ 3 , 5 – 7 , 13 – 21 , 26 ], placental tissues and urine samples were also used ( n = 2) [ 22 , 23 ] and ( n = 1) [ 11 ]. The quality of the studies was satisfactory, eliminating the concern of bias and enhancing the robustness of this meta-analysis and systematic reviews.…”

Section: Resultsmentioning

confidence: 99%

“…However, many of the values used are within the normal reference range [ 5 , 11 ]. Regarding Zn and Cu, studies reported inconsistent higher and lower cut-off values that were highly variable across the identified studies [ 5 , 16 , 19 , 26 ]. Previous research showed inconsistent results for trace metals (Cu, Zn, and Se) in studies that included women with preeclampsia compared to healthy pregnancy [ 7 , 16 , 18 , 19 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…The vast majority of studies [ 7 , 33 ] showed that Cu, Zn, and Se were significantly decreased in women with preeclampsia compared with healthy controls. However, some reported increased levels [ 16 , 19 , 26 ]. Although there was no statistically significant difference, a trend towards reduced Se concentration in plasma was reported in one study [ 7 ].…”

Section: Resultsmentioning

confidence: 99%

“…Recently, oxidative stress markers and trace metals have emerged as diagnostic biomarkers for preeclampsia. Abnormal levels of some trace metals including copper (Cu), zinc (Zn), or selenium (Se) are also associated with preeclampsia [ 5 , 7 , 11 , 16 , 19 , 26 ]. Based on the key pathogenic role of oxidative stress in preeclampsia, several oxidative stress markers have been identified to have promising diagnostic potential [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis

et al. 2022

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Background Preeclampsia is a multifactorial cardiovascular disorder of pregnancy. If left untreated, it can lead to severe maternal and fetal outcomes. Hence, timely diagnosis and management of preeclampsia are extremely important. Biomarkers of oxidative stress are associated with the pathogenesis of preeclampsia and therefore could be indicative of evolving preeclampsia and utilized for timely diagnosis. In this study, we conducted a systematic review and meta-analysis to determine the most reliable oxidative stress biomarkers in preeclampsia, based on their diagnostic sensitivities and specificities as well as their positive and negative predictive values. Methods A systematic search using PubMed, ScienceDirect, ResearchGate, and PLOS databases (1900 to March 2021) identified nine relevant studies including a total of 343 women with preeclampsia and 354 normotensive controls. Results Ischemia-modified albumin (IMA), uric acid (UA), and malondialdehyde (MDA) were associated with 3.38 (95% CI 2.23, 4.53), 3.05 (95% CI 2.39, 3.71), and 2.37 (95% CI 1.03, 3.70) odds ratios for preeclampsia diagnosis, respectively. The IMA showed the most promising diagnostic potential with the positive predictive ratio (PPV) of 0.852 (95% CI 0.728, 0.929) and negative predictive ratio (NPV) of 0.811 (95% CI 0.683, 0.890) for preeclampsia. Minor between-study heterogeneity was reported for these biomarkers (Higgins’ I2 = 0–15.879%). Conclusions This systematic review and meta-analysis identified IMA, UA, and MDA as the most promising oxidative stress biomarkers associated with established preeclampsia. IMA as a biomarker of tissue damage exhibited the best diagnostic test accuracy. Thus, these oxidative stress biomarkers should be further explored in larger cohorts for preeclampsia diagnosis. Graphical Abstract

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