“…29 However, considering that the behavior of the ICP with organic solvent introduction differs markedly from that encountered with aqueous solutions, 1,30,31 knowledge of primary aerosol properties in direct solution introduction is important in the optimization of the nebulizer design and the ICP operating condition to ultimately improve analytical figures of merit or reduce interferences. Ideally, aerosol properties should be predicted through a mathematical model, but a generalized model currently is not available, 22,23,[32][33][34][35][36] particularly for micronebulizers such as the DIHEN.…”