This work presents the elimination of arsenic ions from synthetic produced water via hollow fiber supported liquid membrane (HFSLM). The effects of extractants, pH of feed solution, strippant solutions, and flow rates of feed and strippant solutions are duly investigated. Results demonstrate that arsenic ions in synthetic wastewater could be treated to comply with the standard of wastewater discharged (< 0.25 mg/L) via HFSLM. Percentages of extraction and stripping proved to be 100% and 98%, respectively. Thus, in a single-step operation, arsenic ions are extracted and stripped, using 0.5 M Aliquat 336 as the extractant, at pH of feed solution of 12, with a mixture of thiourea and hydrochloric acid (0.5 M each) as the synergistic strippant solution, and flow rates of both feed and strippant solutions of 100 mL/min. A mathematical model has also been developed to predict the final concentration of arsenic ions in feed and strippant solutions. The results predicted by the mathematical model fit in well with the experimental results.