Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)—5-year follow-up

Behrens, P.; Bitter, T.; Kurz, Bodo; Russlies, Martin

doi:10.1016/j.knee.2006.02.012

Cited by 446 publications

(397 citation statements)

References 35 publications

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“…Despite the small number of patients in our study, the data are consistent with other studies utilizing hyaluronan [21,27] or collagen matrices in longer-term followups [2]. However, BioCart TM II is a human-derived product that is self-adhesive due to its high-interval fibrinogen content, and implantation can be achieved with a minimally invasive surgical approach because there is no need to suture the graft to the defect site; all implants were suitably fixed to the adjacent cartilage with fibrin glue.…”

Section: Discussionsupporting

confidence: 91%

“…Five events of mild effusion were reported by three patients and resolved without any further medical action. This is comparable to complications after implantation of other cell augmented matrices [2,27,34]. No clinically important changes in the blood chemistry and hematology results were recorded in any of the patients participating in the study.…”

Section: Discussionsupporting

confidence: 60%

“…Also, a collagen membrane comprising type 1 and 3 collagen can be used to replace the periosteal patch and allow a more adequate implantation without harvesting periosteum from the adjacent tibia; however, it still needs suture fixation in most cases. The clinical results in these studies meet the success rate of the classic chondrocyte transplantation using the periosteal patch of about 90% good and excellent results for isolated femoral lesions [1,2]. In comparative studies collagen membranes have proven that the periosteal patch can be replaced by a collagen membrane sutured to the defect [34].…”

Section: Discussionmentioning

confidence: 52%

“…Most of the repair tissue fulfilled the criteria of hyaline tissue, which is the prerequisite of a long-lasting regeneration and improved functionality [30]. While longterm studies utilizing biomaterial as a scaffold for cell transplantation are not available, preliminary midterm data up to 5 years suggest improvement as compared with classic ACT [2].…”

Section: Discussionmentioning

confidence: 99%

“…Initially, these matrices were used as a patch [34] but recently have been used as a cellsupport device. Basically, chondrocytes are precultured on the matrix and are implanted as a cell-seeded construct [2,27]. This approach allows a more predictable transport of the cells into the defect without the need for suturing.…”

Section: Introductionmentioning

confidence: 99%

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Results of Chondrocyte Implantation with a Fibrin-Hyaluronan Matrix: A Preliminary Study

Nehrer

Chiari

Domayer

et al. 2008

Clin Orthop Relat Res

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Fibrin, a homologous polymer, is the natural scaffold of wound healing and therefore a candidate as a carrier for cell transplantation. We explored a novel matrix-based implant cartilage repair composed of both fibrin and hyaluronan in a defined ratio that takes advantage of the biological and mechanical properties of these two elements. The matrix was seeded with autologous chondrocytes expanded in the presence of a proprietary growth factor variant designed to preserve their chondrogenic potential. We prospectively followed eight patients with symptomatic-chronic cartilage defects treated with this carrier. Patients had arthroscopy to harvest autologous chondrocytes then grown in autologous serum. Chondrocytes were cultured in the presence of the FGF variant and then seeded on the fibrin-hyaluronan matrix. About 4 weeks following biopsy, the patients underwent implantation of the constructs by miniarthrotomy. Three of the eight patients had transient effusion. Clinical performance was measured by Lysholm and IKDC scores, MRI, and the need for secondary surgery. The clinical outcome of a 1-year followup demonstrated increase of clinical scores.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 60%