ABSTRAKHasil: Didapatkan perbedaan tidak bermakna pada proporsi subjek yang mengalami penurunan kadar MMP-9 pada hari pertama (48% vs 50%; p=0,902;OR=1,(1)(2)(3)(4)(5)(6)(7) p=0,296;OR=1,9); proporsi pengurangan edema serebri (68% vs 80%; p=0,58); LOS (median 12 hari vs 13 hari p=0,256; proporsi subjek dengan LOS ≥15 hari 40% vs 27% p=0,243;OR=1,81; NNT=8).Kesimpulan: Pada pasien PISS yang dilakukan evakuasi hematoma, tigesiklin tidak menurunkan kadar MMP-9 dan derajat edema serebri, serta tidak memperpendek LOS.
ABSTRACT Background:The high plasma level of matrix metalloproteinses-9 (MMP-9) is believed to disrupt the bloodbrain barrier (BBB) and cause brain edema, as well as increase patient's length of hospital stay (LOS). Tigecycline showed ability to reduce the MMP-9 level on study in animals. This study aimed to evaluate whether tigecycline can reduce the plasma levels of MMP-9; brain edema; and LOS of patients with supratentorial spontaneous intracerebral hemorrhage (SSICH).