2014
DOI: 10.1016/j.jstrokecerebrovasdis.2014.07.005
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Matrix Metalloproteinase-9: Dual Role and Temporal Profile in Intracerebral Hemorrhage

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Cited by 67 publications
(43 citation statements)
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“…Animal models and clinical studies have established a timeline for MMP-9 expression and corresponding perihematomal edema (PHE) after intracerebral hemorrhage that include an initial peak on days 1-3 and a secondary peak on day 7. (Chang et al, 2014) The temporal profile of MMP-9 after intracerebral hemorrhage is similar with the observation in brains after stroke/reperfusion, suggesting a bimodal pattern of MMP-9 elevation. (Yang and Rosenberg, 2011b; Yang et al, 2013; Zhao et al, 2006b) At 7 and 14 days, increased MMP-9 signals were found in peri-infarct cortex, which co-localized with NeuN-positive and GFAP-positive cells.…”
Section: Introductionsupporting
confidence: 66%
“…Animal models and clinical studies have established a timeline for MMP-9 expression and corresponding perihematomal edema (PHE) after intracerebral hemorrhage that include an initial peak on days 1-3 and a secondary peak on day 7. (Chang et al, 2014) The temporal profile of MMP-9 after intracerebral hemorrhage is similar with the observation in brains after stroke/reperfusion, suggesting a bimodal pattern of MMP-9 elevation. (Yang and Rosenberg, 2011b; Yang et al, 2013; Zhao et al, 2006b) At 7 and 14 days, increased MMP-9 signals were found in peri-infarct cortex, which co-localized with NeuN-positive and GFAP-positive cells.…”
Section: Introductionsupporting
confidence: 66%
“…23 It is believed that the distinction between study in animals and study in humans stems from the aforementioned conditions. MMP-9 is associated with disruption of BBB that promote brain edema.…”
Section: Discussionmentioning
confidence: 99%
“…Meanwhile, on the second peak, MMP-9 plays role in neuronal recovery. 23 The increase levels of MMP-9 is needed for healing process as well as neurogenesis by promoting migration of activated microglia 30 and endogen stem cells. 31,32 Endogenous neurogenesis was believe to be a powerful tool to repair the brain after SICH.…”
mentioning
confidence: 99%
“…These results appear to corroborate the findings of Tang et al, who showed that MMP-9 knockout mice had increased hemorrhage, brain edema, early neurobehavioral deficits, and mortality in collagenase-induced ICH [71] . However, this paradoxical effect of MMP-9 inhibition in a subacute time frame may actually highlight a dual purpose for MMP expression: a pathological acute phase that contributes to inflammation and cell death and a subacute neuroprotective phase highlighted by angiogenesis [72] . Thus delayed inhibition may interfere with recovery after ICH CONCLUSION MMP regulation in ICH has the potential to be neuroprotective and improve clinical outcome.…”
Section: Post-transcriptional Control Of Mmp Expressionmentioning
confidence: 99%