Matsuda–DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno–Sobetsu study

Furugen, Makoto; Saitoh, Shigeyuki; Ohnishi, Hirofumi; Akasaka, Hiroshi; Mitsumata, Kaneto; Chiba, M; Furukawa, Tetsuaki; Miyazaki, Yoshinori; Shimamoto, Kazuaki; Miura, Tetsuji

doi:10.1038/jhh.2011.23

Cited by 23 publications

(19 citation statements)

References 57 publications

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“…Our findings are in agreement with a previous study where variations in HOMA, as a marker of insulin sensitivity, did not explain BP in men (Poirier et al, 2005). In this context, the ISI-Mat has been shown to be a better predictor for the assessment of hypertension risk compared to the HOMA-IR (Furugen et al, 2012). Moreover, Ferrannini (Ferrannini et al, 1997) investigated, in non-diabetic men and women, the impact of insulin resistance on BP parameters using an euglycemic insulin clamp technique at physiological insulin concentrations and observed in a lean subgroup an inverse association between insulin sensitivity ( M -value) and systolic BP, which is in line with our findings.…”

Section: Discussionmentioning

confidence: 99%

Substantial Inter-Subject Variability in Blood Pressure Responses to Glucose in a Healthy, Non-obese Population

Monnard

Fellay²,

Scerri

et al. 2017

Front. Physiol.

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Aim: A large inter-subject variability in the blood pressure (BP) response to glucose drinks has been reported. However, the underlying factors remain elusive and we hypothesized that accompanying changes in glucose metabolism affect these BP responses.Methods: Cardiovascular and glycemic changes in response to a standard 75 g oral-glucose-tolerance-test were investigated in 30 healthy, non-obese males. Continuous cardiovascular monitoring, including beat-to-beat BP, electrocardiographically deduced heart rate and impedance cardiography, was performed during a 30 min baseline and continued up to 120 min after glucose ingestion. Blood samples were taken at baseline, 30, 60, 90, and 120 min for the assessment of glucose, insulin and c-peptide. Additionally, we evaluated body composition by using validated bioelectrical impedance techniques.Results: Individual overall changes (i.e., averages over 120 min) for systolic BP ranged from −4.9 to +4.7 mmHg, where increases and decreases were equally distributed (50%). Peak changes (i.e., peak averages over 10 min intervals) for systolic BP ranged from −1.3 to +9.5 mmHg, where 93% of subjects increased systolic BP above baseline values (similar for diastolic BP) whilst 63% of subjects increased peak systolic BP by more than 4 mmHg. Changes in peak systolic BP were negatively associated with the calculated Matsuda-index of insulin sensitivity (r = −0.39, p = 0.04) but with no other evaluated parameter including body composition. Moreover, besides a trend toward an association between overall changes in systolic BP and total fat mass percentage (r = +0.32, p = 0.09), no association was found between other body composition parameters and overall BP changes.Conclusion: Substantial inter-subject variability in BP changes was observed in a healthy, non-obese subpopulation in response to an oral glucose load. In 63% of subjects, peak systolic BP increased by more than a clinically relevant 4 mmHg. Peak systolic BP changes, but not overall BP changes, correlated with insulin sensitivity, with little influence of body composition.

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Section: Discussionmentioning

confidence: 99%

Substantial Inter-Subject Variability in Blood Pressure Responses to Glucose in a Healthy, Non-obese Population

Monnard

Fellay²,

Scerri

et al. 2017

Front. Physiol.

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“…This was an observational cross-sectional study performed with 1,152 patients residing in Tanno and Subetsu in Hokkaido, Japan, in 2006 30 31 . The study was approved by Sapporo Medical University’s Institutional Review Board and in accordance with the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

Low alpha-synuclein levels in the blood are associated with insulin resistance

Rodriguez-Araujo

Nakagami²,

Takami

et al. 2015

Sci Rep

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Mutations in the protein alpha-synuclein (SNCA) have been linked to Parkinson’s disease. We recently reported that non-mutated SNCA enhanced glucose uptake through the Gab1-PI3 kinase-Akt pathway and elucidated its effects on glucose regulation. Here, we examined the association of SNCA with insulin resistance (IR), a condition that is characterized by decreased tissue glucose uptake. Our observations include those from a population study as well as a SNCA-deficient mouse model, which had not previously been characterized in an IR scenario. In 1,152 patients, we found that serum SNCA levels were inversely correlated with IR indicators—body mass index, homeostatic model assessment for IR (HOMA-IR) and immunoreactive insulin (IRI)—and, to a lesser extent, with blood pressure and age. Additionally, SNCA-deficient mice displayed alterations in glucose and insulin responses during diet-induced IR. Moreover, during euglycemic clamp assessments, SNCA knock-out mice fed a high-fat diet (HFD) showed severe IR in adipose tissues and skeletal muscle. These findings provide new insights into IR and diabetes and point to SNCA as a potential candidate for further research.

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“…The mechanism of the improvement in GV after CPAP treatment remains unclear, but some speculations are possible. HOMA-R was unchanged after CPAP, but it predominantly reflects hepatic insulin sensitivity and it is not as sensitive to change in whole body insulin resistance as is Matsuda-DeFronzo index or M value obtained by a euglycemic glucose clamp [ 43 ]. Thus, improvement in insulin sensitivity of the skeletal muscle and change in the variability of insulin or glucagon secretion or glucose demand are possible mechanisms underlying the improvement in GV by CPAP in non-DM SDB patients.…”

Section: Discussionmentioning

confidence: 99%

Distinct impacts of sleep-disordered breathing on glycemic variability in patients with and without diabetes mellitus

et al. 2017

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BackgroundSleep-disordered breathing (SDB) is highly prevalent in patients with diabetes mellitus (DM) and heart failure (HF) and contributes to poor cardiovascular outcomes. Enlarged glycemic variability (GV) is a risk factor of cardiac events independently of average blood glucose level, but the influence of SDB on GV is uncertain. In this study, we examined whether the impact of SDB on GV is modified by the presence of DM with or without HF.Methods and resultsTwo hundred three patients (67.5±14.1 [SD] years old, 132 males) who were admitted to our institute for examination or treatment of DM and/or HF underwent continuous glucose monitoring and polysomnography. Both HbA1c (8.0±2.0 vs. 5.7±0.4%) and mean amplitude of glycemic excursion (MAGE, median: 95.5 vs. 63.5 mg/dl) were significantly higher in a DM group (n = 100) than in a non-DM group (n = 103), but apnea-hypopnea index (AHI: 29.0±22.7 vs. 29.3±21.5) was similar in the two groups. AHI was correlated with log MAGE in the non-DM group but not in the DM group, and multivariate regression analysis revealed that AHI was an independent variable for log MAGE in the non-DM group but not in the DM group. We then divided the non-DM patients into two subgroups according to BNP level (100 pg/ml). AHI was positively correlated with log MAGE (r = 0.74, p<0.001) in the non-DM low-BNP subgroup, but such a correlation was not found in the non-DM high-BNP subgroup. Continuous positive airway pressure (CPAP) reduced MAGE from 75.3 to 53.0 mg/dl in the non-DM group but did not reduce MAGE in the DM group.ConclusionSeverity of SDB was associated with higher GV, but DM as well as HF diminished the contribution of SDB to GV. Treatment with CPAP was effective for reduction of GV only in patients without DM.

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Matsuda–DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno–Sobetsu study

Cited by 23 publications

References 57 publications

Substantial Inter-Subject Variability in Blood Pressure Responses to Glucose in a Healthy, Non-obese Population

Substantial Inter-Subject Variability in Blood Pressure Responses to Glucose in a Healthy, Non-obese Population

Low alpha-synuclein levels in the blood are associated with insulin resistance

Distinct impacts of sleep-disordered breathing on glycemic variability in patients with and without diabetes mellitus

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