Mature cystic teratoma of ovary with squamous cell carcinoma arising from it

Abstract

Key Clinical Message Clinicians, pathologists, and radiologists should be aware of rare malignant ovarian tumors arising in mature cystic teratoma (MCT). Suspicion should be raised if the patient is elderly, the tumor is huge, and the tumor has large solid foci. However, malignant transformations in MCTs in younger women have been reported.

Squamous cell carcinoma arising in an ovarian mature cystic teratoma: A case report

“…In our present case also, some thickened or solid parts in the cyst wall were identified on gross examination of surgical pathology specimen. Other studies like those done by Bashyal R et al [3] , by Gupta N et al [4] , by Gupta V et al [10] , by Santwani PM et al [6] and by Maharjan S [15] also show similar findings in gross examination of the tumor specimen itself. Finally, we can say that the teratomas with larger size & variable cyst-wall thickness with thickened or solid area (parts) grossly visible in the cyst-wall have maximum chance of malignant transformations.…”

“…In our present study, it is 12.58 U/ml. In other similar studies done by Bashyal R et al [3], by Goudeli C et al [7] , by Suna Avc1 et al [9] and by Maharjan S [15] , they are 24.19 U/ml, 37.50 U/ml, 57.00 U/ml and 10.70 U/ml respectively. Gupta V et al [10] also reported two cases of malignant transformations in ovarian teratoma with serum CA 125 levels of 40 U/ml & 50 U/ml respectively.…”

“…Age-wise distribution of these cases is mentioned below in table no.1. Name of the study Year of publication Numbers of cases reported Age of occurrence Santwani PM et al [6] 2008 01 40 years Gupta V et al [10] 2009 02 30 years, 65 years Bashyal R et al [3] 2012 03 33 years, 51 years, 60 years Suna Avc1 et al [9] 2012 01 52 years Gupta N et al [4] 2014 01 65 years Ranu Patni [11] 2014 01 53 years Mardi K et al [12] 2014 01 68 years Yarmohammadi H et al [13] 2014 01 48 years Rekhi B et al [14] 2015 12 Median age = 49 years Sharma S et al [1] 2015 01 66 years Abhilasha N et al [8] 2016 10 Median age = 53.5 years Srivastava H et al [2] 2017 01 30 years Goudeli C et al [7] 2017 01 54 years ~ 323 ~ Indulkar ST et al [5] 2018 01 40 years Maharjan S [15] 2019 In our present study, painful enlargement or distension of abdomen is the presenting complaint of the patient herself. Similar complaints have been reported in other case studies also like those done by Bashyal R et al [3] , by Gupta N et al [4] , by Santwani PM et al [6] , etc.…”

“…Name of the study Numbers of cases reported Size of the tumor itself Santwani PM et al [6] 01 12 x 8 cm 2 Gupta V et al [10] 02 12 cm & 16 cm in their maximum dimensions Bashyal R et al [3] 03 15 x 12 x 11 cm 3 , 14 x 9 x 5 cm 3 & 10 x 9 x 4 cm 3 Suna Avc1 et al [9] 01 12 x 7.5 cm 2 Gupta N et al [4] 01 15 x 13 x 10 cm 3 Mardi K et al [12] 01 10 x 6 x 4 cm 3 Yarmohammadi H et al [13] 01 10.3 x 7.6 cm 2 Goudeli C et al [7] 01 22 x 18 x 12 cm 3 Indulkar ST et al [5] 01 10 x 8 x 5 cm 3 Maharjan S [15] 01 10 x 7 xm 2 Present Study 01 8 x 8 x 7 cm 3…”

Meningioma in mature cystic teratoma of the ovary: clinical and computed tomography findings

“…Mature cystic teratomas are the germ cell tumor deriving from primordial germ cells and composes of tissues arising from endoderm, mesoderm, and ectoderm in terms of histology [1]. Malignant elements or the secondary benign tumors in MCTs can also be seen [1,2]. However, the incidence of their co-exist in MCTs is extremely rare.…”