We investigate spectral properties of ordinary differential operators related to expressions of the form D + a. Here a ∈ R and D denotes a composition of d and d + according to the signs in the multi-index , where d is a first order linear differential expression, called delta-derivative, and d + is its formal adjoint in an appropriate L 2 space. In particular, Sturm-Liouville operators that admit the decomposition of the type d + d + a are considered. We propose an approach, based on weak delta-derivatives and delta-Sobolev spaces, which is particularly useful in the study of the operators D +a. Finally we examine a number of examples of operators, which are of the relevant form, naturally arising in analysis of classical orthogonal expansions.