MBG/PLGA composite microspheres with prolonged drug release

Abstract

Mesoporous bioactive glass (MBG) and composite microspheres with MBG particles embedded in biodegradable poly(D,L-lactide-co-glycolide) (PLGA) matrix have been prepared and used to load gentamicin (GS). The in vitro drug release experiments from both MBG and composite microspheres were conducted in distilled water and phosphate buffered saline (PBS) solution at 37 degrees C for more than 30 days. In both water and PBS, GS release from the MBG was very fast with about 60 wt % of the loaded drug released in the first 24 h, and more than 80 wt % released in two days. MBG/PLGA composite microspheres showed an initial release of about 33 wt % in the first day, and 48 wt % in 2 days, and a subsequent sustained release lasting for more than 4 weeks in PBS. MBG/PLGA composite microspheres may be used as an alternative drug release system, especially as a bone void filler for bone repair due to their combined advantages of sustained release of antibiotics and apatite-forming ability.

Mesoporous Bioactive Glasses As Drug Delivery and Bone Tissue Regeneration Platforms

“…MBG has significantly different dissolution compared with NBG and HAp, and the drug-loading and release kinetics of alginate microspheres can effectively be controlled by their dissolution of the inorganic ions [42]. By incorporating MBG future science group into poly(lactic-co-glycolic acid) (PLGA) microspheres, Li et al produced a composite system with a slower release kinetic than pure MBG and a more sustained drug delivery [43]. A novel dual-drug delivery system based on MBG/polypeptide graft copolymer nanomicelle composites was loaded with water-soluble gentamicin and fat-soluble naproxen.…”

Silica‐based mesoporous nanobiomaterials as promoter of bone regeneration process

“…Thus, composite materials combining a mesoporous particle and a biodegradable polymeric phase were developed to mimic the major ECM of bone; they combine the advantages and minimize the drawbacks of each material in the composite . For example, Shi et al showed that the addition of mesoporous bioactive glasses (MBG) into poly( l ‐lactic acid) (PLLA) resulted in enhanced cell attachment with cell spreading and proliferation in a rabbit bone marrow stromal cells (rBMSCs) model . Wu et al fabricated multifunctional porous MBG scaffolds with osteostimulation, drug delivery, and antibacterial properties …”

“…57 For example, Shi et al showed that the addition of mesoporous bioactive glasses (MBG) into poly(L-lactic acid) (PLLA) resulted in enhanced cell attachment with cell spreading and proliferation in a rabbit bone marrow stromal cells (rBMSCs) model. 58 Wu et al fabricated multifunctional porous MBG scaffolds with osteostimulation, drug delivery, and antibacterial properties. 59 Bone morphogenic protein-2 (BMP-2) is considered as one of the most effective and extensively used growth factor to induce osteoblast differentiation and accelerate bone regeneration.…”

Composites of poly(L‐lactide‐trimethylene carbonate‐glycolide) and surface modified SBA‐15 as bone repair material

“…Improved tensile modulus and tensile strength were obtained, but the composites appeared rather brittle . Shi and co‐workers showed that the addition of mesoporous bioactive glass into PLLA matrix enhanced the cell attachment, resulting in cell spreading and proliferation in a rabbit bone marrow stromal cells model …”

“…23 Shi and co-workers showed that the addition of mesoporous bioactive glass into PLLA matrix enhanced the cell attachment, resulting in cell spreading and proliferation in a rabbit bone marrow stromal cells model. 24 In this work, SBA-15 particles were first surface modified using APTES as coupling agent to introduce ammonium groups, followed by grafting of PLLA short chains on the surface through ammonium initiated ring-opening polymerization of L-lactide. Composites of a PLTG matrix reinforced by surface modified SBA-15 with various filler contents were then prepared via solution mixing of both components.…”