Deuterium gas-puff z-pinches are very efficient laboratory sources of neutron pulses. Using a novel hybrid gas-puff load on the GIT-12 generator, a significant increase in the neutron yields up to 5.6×1012 is reached. At the same time, a very broad neutron energy spectrum up to energies on the order of tens of MeV is observed. In these experiments, the neutrons are produced not only by the D(d,n)3He (DD) nuclear reaction but also by reactions of multi-MeV deuterons with the experimental hardware. The angular distribution of the neutron fluence and dependence of the fluence on the distance from the z-pinch are measured using neutron activation diagnostics. By this method, a number of produced non-DD neutrons and anisotropy of DD neutron emission are evaluated.