Mean platelet volume and the ratio of mean platelet volume to platelet count in the diagnosis of acute appendicitis

Avcı, Akkan; Narcı, Hüseyin; Dündar, Güllü Akbaydoğan; Ayrık, Cüneyt; Türkmenoğlu, Özgür

doi:10.1016/j.ajem.2018.05.075

Cited by 28 publications

(35 citation statements)

References 15 publications

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“…Previous studies that compared the WBC count in pediatric and adult patients showed that the WBC count was higher in complicated AA compared with AA and non-AA. 20 – 23 Consistent with the literature, in our study, the WBC count was significantly higher in the complicated AA group compared with the other groups.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of the diagnostic value of platelet indices in pediatric acute appendicitis

Oktay

Boğan

Çolak³

et al. 2020

J Int Med Res

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Objective Abdominal examination findings in pediatric acute appendicitis (AA) significantly vary by age. Therefore, grading systems have been developed for diagnosing pediatric appendicitis, and laboratory and radiological findings have an important role in this diagnosis. However, there is a need to develop new parameters for diagnosing AA. This study aimed to investigate the diagnostic value of platelet indices in AA. Methods This retrospective, observational study included 207 pediatric patients who were admitted to the Emergency Department and operated on for AA. The patients were divided into three groups on the basis of their surgical and histopathological findings (non-AA, uncomplicated AA, and complicated AA). Results There was no significant difference in the mean platelet volume/platelet count (MPV/PC) ratio among the groups. The white blood cell (WBC) count and the MPV/PC ratio showed a significant negative relationship (r = −0.239). The specificity for MPV was 61.8% and the sensitivity was 68.8%. Receiver operating curve analysis of WBC and MPV showed significance for diagnosing AA. Conclusion There is a negative, but weak, relationship between the WBC count and the MPV/PC ratio. However, the MPV/PC ratio could be a useful parameter for diagnosing pediatric AA according to receiver operating curve analysis.

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Section: Discussionsupporting

confidence: 90%

Evaluation of the diagnostic value of platelet indices in pediatric acute appendicitis

Oktay

Boğan

Çolak³

et al. 2020

J Int Med Res

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“…MPV increases with the activation or hyper-aggregation of platelets, reflecting the functional state and volume of platelets in the blood circulation. MPV serves as a negative or positive acute-phase reactant and is a marker of inflammation [11]. Cancer-associated inflammation is involved in the development and dissemination of multiple types of tumors [12].…”

Section: Discussionmentioning

confidence: 99%

Role of Mean Platelet Volume in the Prognosis of Locally Advanced Gastric Cancer: A Tertiary Cancer Center Experience

Manjunath

Jonnada

et al. 2020

Cureus

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Introduction Mean platelet volume (MPV) is an inflammatory marker suggesting the activation of platelets. Many studies observed an association between MPV and cancer spread and metastasis. Hence, we have conducted a retrospective study to find the role of MPV as a prognostic marker in locally advanced gastric cancer. Materials and methods The present study included a retrospective review of 149 patients with gastric cancer who had neoadjuvant chemotherapy followed by surgery. MPV was obtained and then statistically analyzed to find an association between tumor (T), node (N), and overall stage as per the American Joint Committee on Cancer (AJCC) staging system, using Statistical Package for the Social Sciences (SPSS) software (IBM Corp., Armonk, NY). Results In our study, we observed that MPV values were significantly high in N+ disease (OR 3.794 (95% CI 1.903-7.563); p-value 0.0001), higher T stage (OR for >T2 3.692 (95% CI 1.876-7.266); pvalue 0.0001), and advanced stage (OR 7.708 (95% CI 3.258-18.237); p-value 0.0001) of gastric cancer. Conclusions MPV is an inflammatory marker that correlates with nodal disease and aids in the staging and prognostication of locally advanced gastric cancer. This inexpensive, convenient marker can aid in the risk stratification of locally advanced gastric cancer.

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“…Second, platelets are an acute phase reactant indices change in accordance with infectious and inflammatory processes. We decided to employ the ratio of the PC and MPV in our analysis because several studies have demonstrated that PC increase while MPV decreases during reactive thrombocytosis, which creates a larger P/V ratio and potentially accounts for patients with baseline thrombocytosis [1,7,8,21]. Although platelets were traditionally thought of as only an ancillary player in our bodies response to infection, primarily via the synthesis and secretion of inflammatory cytokines like interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF), recent literature demonstrate that they play a much more active role than previously thought [8,9,19,20].…”

Section: Discussionmentioning

confidence: 99%

“…There are numerous studies that have extensively described the role that platelets play in our bodies inflammatory response to bacterial invasion [6,12,20]. In addition, there have been a handful of studies that have investigated the potential role that the indices we use to measure platelets may play in the diagnostic evaluation of a variety of inflammatory and infectious states [1,4,7,21]. However, there is a paucity of literature investigating these indices, specifically when measured as a ratio (P/V), in the realm of orthopaedic surgery and more importantly FRI.…”

Section: Ivyspringmentioning

confidence: 99%

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An Adjunct Indicator for the Diagnosis of Fracture-Related Infections: Platelet Count to Mean Platelet Volume Ratio

Strony

Paziuk

Fram

et al. 2020

J. Bone Joint Infect.

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Abstract. Introduction: Fracture-related infection (FRI) is a common complication associated with orthopaedic fracture care. Diagnosing these complications in the preoperative setting is difficult. Platelets are a known acute phase reactant with indices that change in accordance with infection and inflammation. The purpose of our study was to assess the diagnostic utility of platelet indices at assessing FRI.Methods: A retrospective review performed for all patients who underwent revision surgery for fracture nonunion between 2013 and 2018. Radiographs were employed to define nonunion. Intraoperative cultures were used to define FRI. Receiver operator characteristic (ROC) curve analysis was used to assess the diagnostic ability of preoperative erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and the platelet count/mean platelet volume ratio (P/V) at recognizing FRI.Results: Of the 53 revision surgeries that were performed for fracture nonunion, 17 (32.1%) were identified as FRI. There were no significant demographic differences between the two cohorts. Patients with FRIs exhibited higher values for ESR (54.82 vs. 19.16, p<0.001), CRP (0.90 vs. 0.35, p=0.003), and P/V (37.4 vs. 22.8, p<0.001) as compared to those within the aseptic nonunion cohort. ROC curve analysis for P/V demonstrated that at an optimal ratio of 23, area under the curve (AUC) is 0.814, specificity is 55.6%, and sensitivity is 100.0%. There was no significant difference in the diagnostic performance of the serum biomarkers but only ESR and P/V had an AUC greater than 0.80. The negative predictive value (NPV) for P/V, ESR, and CRP was 100.0%, 84.6%, and 78.6%, respectively.Conclusion: The P/V ratio may serve as a reliable screening test for FRI.

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Mean platelet volume and the ratio of mean platelet volume to platelet count in the diagnosis of acute appendicitis

Cited by 28 publications

References 15 publications

Evaluation of the diagnostic value of platelet indices in pediatric acute appendicitis

Evaluation of the diagnostic value of platelet indices in pediatric acute appendicitis

Role of Mean Platelet Volume in the Prognosis of Locally Advanced Gastric Cancer: A Tertiary Cancer Center Experience

An Adjunct Indicator for the Diagnosis of Fracture-Related Infections: Platelet Count to Mean Platelet Volume Ratio

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