Measles Virus: A Summary of Experiments Concerned with Isolation, Properties, and Behavior

Methods of determining immunity, duration and character of immunity resulting from measles

“…Now the Tween-ether-split product and a separated, nonhemagglutinating CF antigen are available too. 3 emphasize earlier results (32,33,34) on the perfect correlation between the presence of HI and/or N antibodies and that of CF antibodies in early convalescent sera. One of them is associated with the hemagglutinin and located in the envelope of the virus (V antigen).…”

Canine distemper virus in primary and continuous cell lines of human and monkey origin

“…Only limited descriptions of the growth of measles virus in human fibroblasts have been published. Enders et al (1957) noted that primary human embryonic fibroblasts gave rise to cells of abnormal appearance following inoculation of the Edmonston strain of measles virus. Berg and RosenthaI (196I) noted chronic measles virus infection in primary human fibroblast cell cultures derived from normal and leukemic bone marrow.…”

Affinity Thresholds for Membrane Fusion Triggering by Viral Glycoproteins

“…Measles virus (MV) is a negative-strand RNA virus belonging to the family Paramyxoviridae. The virus was originally isolated in 1954 from the throat of a patient with measles (6) and has since been subjected to serial tissue culture passage to create an attenuated (Edmonston) vaccine strain (7) that is showing considerable promise in oncolytic virotherapy studies (4,10,30,32,33). Oncolytic measles viruses use either one of two receptors to infect their target cells: CD46, which is expressed on all human nucleated cells (5,24), or the signaling lymphocyte activation molecule (SLAM), which is expressed on activated T cells, B cells, and monocytes (14,46).…”