Measurement of retinal nerve fiber layer thickness, macular thickness, and foveal volume in amblyopic eyes using spectral-domain optical coherence tomography

Dickmann, Anna; Petroni, Sergio; Perrotta, Vittoria; Parrilla, Rosa; Aliberti, Stefania; Salerni, Annabella; Savastano, Maria Cristina

doi:10.1016/j.jaapos.2011.09.011

Cited by 37 publications

(25 citation statements)

References 12 publications

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“…Wu et al31 reported that the central macular thickness values in the 1 mm and 3 mm regions were not significantly different in amblyopic and normal fellow eyes, although the mean macular foveolar thickness was significantly thicker in the amblyopic eyes than in the fellow eyes. We did not examine the foveolar thickness in this study; however, there were no differences in the macular full retinal thickness in the 1 mm region, similar to that observed in most previous studies 28,29,31–34. However, the macular full retinal thickness in the 3 mm region was significantly thicker in the amblyopic eyes than in the fellow eyes.…”

Section: Discussionsupporting

confidence: 80%

“…In addition, Wu et al31 reported that anisometropic amblyopes had thicker cpRNFL values in the amblyopic eye than in the fellow eye based on SD-OCT. Our present data is in agreement with these results. In contrast, some studies that have investigated the cpRNFL thickness in amblyopic eyes using SD-OCT found no significant differences compared to that observed in controls 27,29,32. Regarding this contradiction, Kim et al34 pointed out that the majority of these studies did not correct the ocular magnification errors related to refraction and axial length, whereas most previous studies included patients with anisometropia.…”

Section: Discussionmentioning

confidence: 94%

“…Among previous studies using SD-OCT, most reported that there were no differences in macular thickness between amblyopic and normal fellow eyes,28,29,31–34 although some showed that the macular thickness in the amblyopic eyes was greater than that observed in the normal fellow eyes 27,30. Wu et al31 reported that the central macular thickness values in the 1 mm and 3 mm regions were not significantly different in amblyopic and normal fellow eyes, although the mean macular foveolar thickness was significantly thicker in the amblyopic eyes than in the fellow eyes.…”

Section: Discussionmentioning

confidence: 99%

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A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

Araki¹,

Miki²,

Yamashita³

et al. 2014

OPTH

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PurposeTo compare the macular retinal thickness and characteristics of optic nerve head (ONH) parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.Patients and methodsA total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both) were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer), ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio).ResultsThe amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001). Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01), macular full retinal thickness (3 mm region) (P<0.01), and macular outer retinal thickness (1 and 3 mm regions) (P<0.05) were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region), and macular inner retinal thickness (1 and 3 mm regions) were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05). None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=−0.48; P<0.01, r=−0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.ConclusionWe found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

Araki¹,

Miki²,

Yamashita³

et al. 2014

OPTH

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“…Alotaibi and Dickmann suggested based on their findings that amblyopia of different etiologies is associated with the loss of different neural cells [20], [23], [24]. Later, in 2012, Dickmann evaluated 15 strabismic (esotropic) and 15 anisometropic amblyopic patients, and found no intereye differences in cpRNFL, macular thickness and foveal volume in neither group using spectral-domain (SD) OCT [28].…”

Section: Discussionmentioning

confidence: 99%

A Morphological Study of Retinal Changes in Unilateral Amblyopia Using Optical Coherence Tomography Image Segmentation

et al. 2014

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ObjectiveThe purpose of this study was to evaluate the possible structural changes of the macula in patients with unilateral amblyopia using optical coherence tomography (OCT) image segmentation.Patients and Methods38 consecutive patients (16 male; mean age 32.4±17.6 years; range 6–67 years) with unilateral amblyopia were involved in this study. OCT examinations were performed with a time-domain OCT device, and a custom-built OCT image analysis software (OCTRIMA) was used for OCT image segmentation. The axial length (AL) was measured by a LenStar LS 900 device. Macular layer thickness, AL and manifest spherical equivalent refraction (MRSE) of the amblyopic eye were compared to that of the fellow eye. We studied if the type of amblyopia (strabismus without anisometropia, anisometropia without strabismus, strabismus with anisometropia) had any influence on macular layer thickness values.ResultsThere was significant difference between the amblyopic and fellow eyes in MRSE and AL in all subgroups. Comparing the amblyopic and fellow eyes, we found a statistically significant difference only in the thickness of the outer nuclear layer in the central region using linear mixed model analysis keeping AL and age under control (p = 0.032). There was no significant difference in interocular difference in the thickness of any macular layers between the subgroups with one-way between-groups ANCOVA while statistically controlling for interocular difference in AL and age.ConclusionsAccording to our results there are subtle changes in amblyopic eyes affecting the outer nuclear layer of the fovea suggesting the possible involvement of the photoreceptors. However, further studies are warranted to support this hypothesis.

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“…8 Dickmann ve ark. 9 anizometropik ambliyopisi ve şaşılık ambliyopisi olan iki ayrı grupta yaptıkları çalışmada, sağlam ve ambliyop gözlerin maküla ve RSLT kalınlıkları arasında istatistiksel olarak anlamlı fark olmadığını bildirmişlerdir. Bizim çalışmamıza tek taraflı anizometropik ambliyop olgular dahil edilerek, olguların sadece maküla kalınlıkları iki farklı ölçüm modu ile değerlendirildi.…”

Section: Discussionunclassified

Optik Koherens Tomografi ile Arka Kutup Analizi ve Maküla KalınlığıÖlçüm Modu Sonuçlarının Tek Taraflı Anizometropik Ambliyoplarda Karşılaştırılması

Ulaş¹,

Kaymaz²,

Doğan³

et al. 2013

Tjo

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Amaç: Optik koherens tomografi (OKT) cihazıyla tek taraflı anizometropik ambliyopisi olan çocuk yaş grubundaki olgularda arka kutup analizi (AKA) ve maküla kalınlığı ölçüm modunda alınan ölçümlerin karşılaştırılması. Ge reç ve Yön tem: Kliniğimizde takip edilen 6-17 yaş arası 37 tek taraflı anizometropik ambliyopi olgusunun 74 gözünün OKT cihazıyla AKA ve maküla kalınlığı ölçüm modu sonuçları değerlendirildi. Tüm ölçümler aynı seansta, pupilla dilate edilmeksizin aynı deneyimli hekim tarafından yapıldı. AKA ve maküla kalınlığı ölçüm modu çekimleri rastgele sırayla yapıldı. AKA ve maküla kalınlığı ölçüm modu sonuçlarının karşılaştırılması için her iki ölçüm modunda da ortak olarak elde edilebilen maküla kalınlık haritası sonuçları değerlendirildi. Sağlam ve ambliyop gözlerde AKA ve maküla kalınlığı ölçüm modu sonuçlarının karşılaştırılması eşleştirilmiş örneklem t-testiyle, ambliyop ve sağlam gözlerin retina kalınlıkları arasındaki farkın araştırılması bağımsız örneklem ttesti ile değerlendirildi. So nuç lar: Ambliyop gözlerde AKA ve maküla kalınlığı ölçüm modunda alınan ölçümler arasında değerlendirilen tüm segmentlerde istatistiksel olarak anlamlı fark saptanmadı (p değerleri tüm segmentler için 0,10'un üzerinde idi). Sağlam gözlerde AKA ve maküla kalınlığı ölçüm modunda alınan ölçümler arasında merkezi, superior, inferior ve nazal segmentlerde istatistiksel fark saptanmazken (p değerleri tüm segmentler için 0,16'nın üzerinde idi), temporal segmentte anlamlı fark saptandı (p=0,04). Sağlam ve ambliyop gözlerin maküla kalınlıkları karşılaştırıldığında her iki ölçüm modunda da maküla kalınlıkları arasında istatistiksel olarak anlamlı fark saptanmadı (p değerleri tüm segmentler için 0,24'ün üzerinde idi). Tar t›fl ma: Tek taraflı anizometropik ambliyopisi olan olgularda, OKT cihazının farklı çekim modlarında alınan maküla kalınlığı ölçümleri anizometropik ambliyop ve sağlam gözlerde benzerlik göstermektedir. Ancak makülanın temporal segment ölçüm değerleri dikkatli değerlendirilmelidir. (Turk J Ophthalmol 2013; 43: 113-7) Anah tar Ke li me ler: Ambliyopi, arka kutup analizi, maküla, optik koherens tomografi Sum maryPur po se: To compare the optical coherence tomography (OCT) measurements using posterior pole analysis (PPA) and macular thickness measurement mode in pediatric cases with unilateral anisometropic amblyopia. Ma te ri al and Met hod: This study included 74 eyes of 37 patients aging between 6-17 years with unilateral anisometropic amblyopia. PPA and macular thickness measurement mode OCT scans were performed, and measurements of amblyopic and fellow eyes were evaluated. All OCT scans were performed by a single experienced doctor without pupil dilation within one session. Measurement sequence was randomly assigned for PPA and macular thickness measurement mode for amblyopic and fellow eyes. Retinal thickness measurements by using PPA and macular thickness measurement mode were compared using the paired samples ttest. Statistical analyses of retinal thickness differences between the amblyopic and fellow eye...

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Measurement of retinal nerve fiber layer thickness, macular thickness, and foveal volume in amblyopic eyes using spectral-domain optical coherence tomography

Cited by 37 publications

References 12 publications

A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

A Morphological Study of Retinal Changes in Unilateral Amblyopia Using Optical Coherence Tomography Image Segmentation

Optik Koherens Tomografi ile Arka Kutup Analizi ve Maküla KalınlığıÖlçüm Modu Sonuçlarının Tek Taraflı Anizometropik Ambliyoplarda Karşılaştırılması

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