Measurement of the villus surface in normal and pathologic placentas

Clavero, J.A.; Llusiá, José Botella

doi:10.1016/0002-9378(63)90436-8

Cited by 56 publications

(9 citation statements)

References 4 publications

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“…12 In the present, no significant macroscopic and microscopic changes were observed in placentae from Heart disease. This was similar with observation of Clavero et al…”

Section: Heart Diseasecontrasting

confidence: 63%

Clinical correlation with pathology of placenta in medical disorders of pregnancy and its comparison in normal pregnancy

Siddheshware

Patil

Sambarey

2016

Int J Reprod Contracept Obstet Gynecol

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Background: Healthy placenta is responsible for maintaining pregnancy and promoting normal foetal development. It reflects the intrauterine status of the foetus. Methods: In the present prospective study, total 50 Placentae from Medical Disorders of Pregnancies were studied and compared with equal number of Placentae from normal Pregnancies. Results: The significant macroscopic changes were calcification and infarction seen in Hypertensive Disorder. Extensive placental infarction was associated with high incidence of low APGAR (82%) and perinatal deaths (66.67%). No significant gross macroscopic changes were seen in Anaemia, Diabetes Mellitus and Heart Disease. Increased syncytial knots, fibrinoid degeneration, vasculo-syncytial membrane paucity were significant microscopic changes in Hypertensive Disorder. In Anaemia stromal fibrosis, increased syncytial knots were seen, whereas in Diabetes Mellitus villous edema was the most significant microscopic finding. No significant microscopic change was found in Heart Disease. Increased syncytial knots, fibrinoid degeneration, vasculo-syncytial membrane paucity, stromal fibrosis were associated with increased perinatal mortality. Conclusions: Gross and microscopic examination of placenta is strongly recommended in cases where maternal comorbid conditions is likely to have an adverse perinatal outcome.

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“…12 In the present, no significant macroscopic and microscopic changes were observed in placentae from Heart disease. This was similar with observation of Clavero et al…”

Section: Heart Diseasecontrasting

confidence: 63%

Clinical correlation with pathology of placenta in medical disorders of pregnancy and its comparison in normal pregnancy

Siddheshware

Patil

Sambarey

2016

Int J Reprod Contracept Obstet Gynecol

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“…In addition, since they are important parameters of the functional placental model, the question of how accurately the morphometric data reflect the apparent 150-200-cm3 size of the intervillous space and the 50-60-cm3 size of the capillary bed as measured [54] in vivo must be raised. The villous surface area estimated from the ratio of nuclei to chorionic surface, was 6.4 (SD±0.3) m2 [55], and by planimetry has been found to vary from 10.3 to 16 m2 [9,10,[56][57][58][59]. Only in the case of the studies of A herne and D u n n ill [9,10] at Oxford can these measures be compared with other morphometric features.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Studies of Human Placenta I.

Laga¹,

Driscoll²,

Munro³

1973

Neonatology

105

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Eighteen term placentas from a middle-class North American urban population were examined by stereologic techniques and an image quantizer. The trimmed placental weight averaged 469 g, of which 339 g was Ê»functional parenchyma’ and 130 g Ê»nonparenchymal tissue’ (decidual and chorionic plates and large vessels and pathological components such as infarcts). Microscopically, the parenchyma was divided into villi and intervillous space. The volume of intervillous space was, at 110 cm³, significantly larger than that of the villous capillaries, which measured 30 cm³. The mass of the chorionic villi averaged 214 g and comprised 168 g of peripheral and 46 g of stem villi. Most of the 60 g of trophoblast and of the 31.5 g of fibroblasts, and a significant fraction of the 91 g of collagenous stroma were present in the peripheral villi. The longest diameter of the peripheral villi averaged 74 µm and their cross-sectional area 1,100 µm². The surface area of the peripheral villi was 16 m² and that of the corresponding xillous capillaries 12 m². A model for estimating placental oxygen diffusion capacity (Dpo₂) was constructed on the basis of these stereologic measurements. The resistance to oxygen diffusion from maternal to fetal red cells in the placenta was attributed to five serial compartments i.e. (1) the oxygen-hemoglobin interactions in the maternal red cells in the intervillous space; (2) the maternal blood plasma in the intervillous space; (3) the villous membrane comprising syncytiotrophoblast, basement membrane, connective tissue and fetal capillary wall; (4) the fetal blood plasma, in the villous capillaries and (5) the oxygen-hemoglobin interactions in the fetal red cells present in the villous capillaries. The diffusion capacity of the placental membrane (D_M), comprising (2–4), was 3.256 and that of the total placenta 3.086 ml oxygen min^––¹ · mm Hg^––1. The corresponding specific diffusion capacities per 100 g of placenta were 0.694 for the placental membrane (D_M/w) and 0.658 ml. min^––1 · mm Hg^––1 for the whole placenta (D_P/_w). The resistance of the villous membrane was consequently the limiting factor in oxygen diffusion, both when considering the 110-ml maternal and 30-ml fetal blood volumes as the effective exchangers or when considering a single capillary transit for oxygen with 10 ml in each of the maternal and fetal compartments.

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“…The displaced water drained through the tube was collected in a container and measured in a graduated cylinder in milliliters. 12 Results were obtained by calculating means, standard deviations (SD) and analyzing significant difference using a computer-based program (SPSS, version11). The post Hoc option of analysis of variance (ANOVA) was done to compare three groups for each variable.…”

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confidence: 99%