Measurement of β-tryptase in postmortem serum in cardiac deaths

Palmière, Cristian; Comment, Lionel; Vilarino, Raquel; Mangin, Patrice; Bonetti, Luca Reggiani

doi:10.1016/j.jflm.2014.01.009

Cited by 21 publications

(12 citation statements)

References 37 publications

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“…These changes were of moderate severity in the third group that was sensitized by penicillin G in comparison to the second group. The studies in [42,43] suggested that non-specific postmortem findings in systemic anaphylaxis are usually due to generalized mast cell degranulation which is attributed to an immunological reaction leading to the release of mediators from the mast cells causing vasodilatation along with an increase in vascular permeability, and then a generalized congestion and edema in the different body organs such as the spleen which is in agreement with [44,45,46] that showed that the mast cell quantification in splenic red pulp and serum tryptase assessment may help diagnose fatal anaphylactic shock with a high degree of sureness.…”

Section: Discussionsupporting

confidence: 55%

Postmortem Diagnosis of Induced Fatal Anaphylactic Shock in Rats

Elshama

Salem

Osman

et al. 2018

ARRB

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Anaphylactic shock is a sudden and serious life-threatening systemic hypersensitivity leading to a rapid, irreversible fatal circulatory collapse. Postmortem diagnosis of fatal anaphylaxis is a very sophisticated task in forensic medicine; it is usually excluded as the cause of death due to lack of autopsy findings. This study aims to find more specific criteria for the postmortem diagnosis of induced fatal anaphylaxis in rats by assessing the levels of total tryptase, histamine,

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Section: Discussionsupporting

confidence: 55%

Postmortem Diagnosis of Induced Fatal Anaphylactic Shock in Rats

Elshama

Salem

Osman

et al. 2018

ARRB

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“…In a several studies evaluating postmortem blood concentrations of tryptase and ß-tryptase were detected very high in contrast medium anaphylaxis [54], less in food anaphylaxis [55], and intermediate in insect bites-related anaphylaxis [56]. On the other hand, cases as heroin-related deaths [57], or posttraumatic deaths and hearth diseases [54] were not clearly related to ß-tryptase levels. Eosinophilic cationic protein (ECP) is a basic protein located in the eosinophil and ECP is released during degranulation of eosinophils.…”

Section: Diagnosis Of Disease and Cause Of Deathmentioning

confidence: 96%

“…[44] Pittner et al [45] MS-based proteomics Choi et al [46] Handke et al [47] Procopio et al [49] Prieto-Bonete et al [50] Intoxication and abuse of drugs MS-based proteomics Bittencourt et al [51] Diagnosis of disease and cause of death MS-based proteomics Broadbelt at al. [53] Palmiere et al [54] Immunohistochemistry Unkrig et al [55] Mustafa et al [56] Fineschi et al [57] Edston and van Hage-Hamsten [58] Genomics Detection of the biological specimens PCR Nakanishi et al [12] Postmortem interval PCR Pechal et al [19] Intoxication and abuse of drugs PCR Sallaee et al [62] Ikematsu et al…”

Section: Sds-page Western Blotmentioning

confidence: 99%

Omics era in forensic medicine: towards a new age

Akçan¹,

Taştekin²,

Yıldırım³

et al. 2020

Turk J Med Sci

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Introduction The topic "forensic medicine and sciences" is a subdivision of science which is described as the practice of medical/ paramedical scientific knowledge to establish facts in civil and criminal law [1]. Forensic medicine has a multidisciplinary structure in collaboration with other areas such as forensic chemistry, toxicology, biology, psychiatry, and genetics, etc. Since forensic sciences share a common scientific methodology with other science disciplines it is open to collaborate or benefit from novel technologies appeared in any scientific discipline. Therefore, omics emerges as a revolutionary step in forensic sciences and sure carries it towards a new age. The publications regarding omics in various disciplines have become a rising scientific trend worldwide, during the last decade. Furthermore, the number of forensic studies utilizing the methodology of omics has enormously increased in last years. In order to draw attention of forensic and medical professionals, and encourage new studies; the roles and benefits of omics in forensic medicine and sciences are discussed in this review. 2. Omics Omics is a novel multidisciplinary field of various scientific methodologies. Omics defines the collective technologies that measure some characteristics (roles, relationships, and actions) of certain molecules like metabolites, proteins and genes, ending in-omics, as in metabolomics, proteomics, genomics, etc. In past years, omics technologies were applied to diverse fields, because of the ability to assess little changes in a large-scale data with exhaustive metabolite evaluation [2]. With the development of technology, omics-based strategies become cheaper, faster, and very informative, and offer potent alternatives to conventional technics. Furthermore, sample selection has a key role to success in target study. Various human samples can be used for analysis such as blood [3,4], urine [5], hair [6,7], nail [8-10], faeces[11,12], aqueous humour [13] etc. The interactions of omics with each other have been shown in Figure. 2.1. Metabolomics 2.1.1. Definition of metabolomics Metabolomics comprises the studies that are focused on assessment of metabolites and related markers of an Background/aim: Forensic medicine and sciences is a multidisciplinary branch of science, which frequently benefit from novel technologies. State of the art omics technologies have begun to be performed in forensic medicine and sciences, particularly in postmortem interval, intoxication, drugs of abuse, diagnosis of diseases and cause of death. This review aims to discuss the role and use of great omics (metabolomics, proteomics, genomics and transcriptomics) in forensic sciences, in detail. Materials and methods: A detailed review of related literature was performed, and studies were subdivided as per the type of omics. Results and conclusion: Omics seems as a revolutionary step in forensic science and sure carries it towards a new age. The number of forensic studies utilizing omics steadily increases in last years. Omics strategi...

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“…Many clinical cardiac biomarkers were tested in post-mortem examination [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. The postmortem experimental use of the old cTn assay started early already in the 2000s.…”

Section: Introductionmentioning

confidence: 99%