Measuring urinary concentrations of neonicotinoid insecticides by modified solid-phase extraction–ultrahigh performance liquid chromatography–tandem mass spectrometry: Application to human exposure and risk assessment

Zhou, Wenli; Yue, Min; Q, Liu; Wang, Feng; Liu, Liying; Wang, Lu; Liu, Xiaoqiang; Zheng, Min; Xiao, Hong; Bai, Qunhua; Gao, Jieying

doi:10.1016/j.chemosphere.2021.129714

Cited by 22 publications

(2 citation statements)

References 53 publications

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“…In harvested crops (e.g., cabbage, bell peppers, dried hops, cucumbers, and oranges) and water sources, the main metabolites of FLO, N -(4-trifluoromethylnicotinoyl) glycinamide (TFNG-AM), 4-(trifluoromethyl) nicotinoyl glycine (TFNG), and 5-trifluoromethylnicotinic acid (TFNA) have been detected [ 2 , 3 , 4 , 5 ]. In addition to this, traces of FLO have been found in human urine and serum samples [ 6 , 7 ]. The mouse genome can be significantly damaged by high doses of FLO [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Efficient Biodegradation of the Neonicotinoid Insecticide Flonicamid by Pseudaminobacter salicylatoxidans CGMCC 1.17248: Kinetics, Pathways, and Enzyme Properties

Zhao,

Yuan,

Song

et al. 2024

Microorganisms

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Nitrile-containing insecticides can be converted into their amide derivatives by Pseudaminobacter salicylatoxidans. N-(4-trifluoromethylnicotinoyl) glycinamide (TFNG-AM) is converted to 4-(trifluoromethyl) nicotinoyl glycine (TFNG) using nitrile hydratase/amidase. However, the amidase that catalyzes this bioconversion has not yet been fully elucidated. In this study, it was discovered that flonicamid (FLO) is degraded by P. salicylatoxidans into the acid metabolite TFNG via the intermediate TFNG-AM. A half-life of 18.7 h was observed for P. salicylatoxidans resting cells, which transformed 82.8% of the available FLO in 48 h. The resulting amide metabolite, TFNG-AM, was almost all converted to TFNG within 19 d. A novel amidase-encoding gene was cloned and overexpressed in Escherichia coli. The enzyme, PmsiA, hydrolyzed TFNG-AM to TFNG. Despite being categorized as a member of the amidase signature enzyme superfamily, PsmiA only shares 20–30% identity with the 14 previously identified members of this family, indicating that PsmiA represents a novel class of enzyme. Homology structural modeling and molecular docking analyses suggested that key residues Glu247 and Met242 may significantly impact the catalytic activity of PsmiA. This study contributes to our understanding of the biodegradation process of nitrile-containing insecticides and the relationship between the structure and function of metabolic enzymes.

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Section: Introductionmentioning

confidence: 99%

Efficient Biodegradation of the Neonicotinoid Insecticide Flonicamid by Pseudaminobacter salicylatoxidans CGMCC 1.17248: Kinetics, Pathways, and Enzyme Properties

Zhao,

Yuan,

Song

et al. 2024

Microorganisms

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“…In recent years, some reports have shown that NTP has frequently appeared in tea (Li et al 2020b). Not only that, NTP has been detected in infants (2.8% of children had a hazard index between 0.1 and 1.0) and adolescents (1.79 μg g −1 creatinine) (Wang et al 2020b;Zhou et al 2021b), and tap water and fresh vegetables are presumed to be potential sources. Although the researchers suggest it is not very harmful to human health, NTP is highly toxic to bees, an agriculturally important organism.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the synergistic effect of internal Fe single atoms and introduced Fe3C in Enteromorpha derived biochar with enhanced peroxymonosulfate activation property towards nitenpyram removal

Xiong

Zeng

Deng

et al. 2023

Biochar

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This work demonstrated that Enteromorpha biochar with introduced iron (SFB900-3) could activate peroxymonosulfate (PMS) efficiently for NTP remediation. It removed 83.9%–95.1% of NTP in 60 min under a wide pH range from 3.15 to 8.95. Density functional theory (DFT) calculations revealed the synergistic relationship between internal Fe single atoms and introduced Fe compounds—Fe3C. The adsorption capacity of SFB900-3 for persulfate improved from −0.953 eV to −4.214 eV, and the Bader charge analysis showed that Fe atoms as active sites (0.658 e) enhanced the adsorption capacity more than carbon (0.050 e). Moreover, the energy barrier for PMS dissociation reduced from 0.072 eV to −5.372 eV due to the longer length of O–O bond under the synergistic effect of Fe single atom and Fe3C which increased from 1.467 Å to 3.890 Å. The quenching experiment confirmed that 1O2 was the main active substance in NTP degradation and its contribution rate was 88.2%, which was further verified by EPR detection. The effect factor experiments proved that the SFB900-3/PMS system had stable and efficient activity for NTP removal, which remained at 73.6% removal rate after three rounds of tests. This work provided novel guidance for constructing efficient and stable biochar-based materials for organic pollutant remediation. Graphical Abstract

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Prenatal Exposure to Neonicotinoids and the Associations with Neonatal Birth Outcomes and Maternal Health in South China

Fu,

Yao,

Huang

et al. 2024

Expo Health

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Measuring urinary concentrations of neonicotinoid insecticides by modified solid-phase extraction–ultrahigh performance liquid chromatography–tandem mass spectrometry: Application to human exposure and risk assessment

Cited by 22 publications

References 53 publications

Efficient Biodegradation of the Neonicotinoid Insecticide Flonicamid by Pseudaminobacter salicylatoxidans CGMCC 1.17248: Kinetics, Pathways, and Enzyme Properties

Efficient Biodegradation of the Neonicotinoid Insecticide Flonicamid by Pseudaminobacter salicylatoxidans CGMCC 1.17248: Kinetics, Pathways, and Enzyme Properties

Unveiling the synergistic effect of internal Fe single atoms and introduced Fe3C in Enteromorpha derived biochar with enhanced peroxymonosulfate activation property towards nitenpyram removal

Prenatal Exposure to Neonicotinoids and the Associations with Neonatal Birth Outcomes and Maternal Health in South China

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