Mebeverine‐Loaded Electrospun Nanofibers: Physicochemical Characterization and Dissolution Studies

Illangakoon, Upulitha Eranka; Nazir, Tahir; Williams, Gareth R.; Chatterton, Nicholas P.

doi:10.1002/jps.23759

Cited by 47 publications

(30 citation statements)

References 38 publications

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“…For pure EL, there was a broad endotherm between 50°C and 110°C due to dehydration and a second one ranging from 195°C to 219°C, which may be due to thermal degradation. These findings were consistent with other results documented by Illangakoon et al 45 ES exhibited broad glass transition (Tg) endothermic peaks at 90°C and 230°C as reported by Karthikeyan et al 16 These data confirmed that both ES and EL are amorphous as reported previously.…”

Section: Drug Loadingsupporting

confidence: 93%

Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis

Reda

Wen

El-Kamel

2017

IJN

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Section: Drug Loadingsupporting

confidence: 93%

Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis

Reda

Wen

El-Kamel

2017

IJN

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“…For the preparation of electrospun ASDs of poorly water-soluble drugs, the most commonly explored polymers are water-soluble materials such as PVP, PEO, PVA and HPMC [141][142][143]. However, water-insoluble polymers have also been exploited in developing new types of ASDs which release the drug in a controlled manner to give improved bioavailability [144].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Their conversion to solid dosage forms for potential consumer products may however also require downstream processing methods, as addressed in several publications, using traditional pharmaceutical technologies [171]. Nanofiberbased ASDs can be easily cut into wafers [172] or formulated as tablets or capsules for oral administration [173], applied as patches for topical applications, or utilised as vaginal suppositories or drug eluting stents [142]. Nanofibers in the form of nonwoven fabrics have significant advantages in their ease of onward processing compared with nanoparticulate ASDs.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Williams

et al. 2018

Journal of Controlled Release

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250

156

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The development of oral dosage forms for poorly water-soluble active pharmaceutical ingredients (APIs) is a persistent challenge. A range of methods has been explored to address this issue, and amorphous solid dispersions (ASDs) have received increasing attention. ASDs are typically prepared by starting with a liquid precursor (a solution or melt) and applying energy for solidification. Many techniques can be used, with the emergence of electrospinning as a potent option in recent years. This method uses electrical energy to induce changes from liquid to solid. Through the direct applications of electrical energy, electrospinning can generate nanofiber-based ASDs from drug-loaded solutions, melts and melt-solutions. The technique can also be combined with other approaches using the application of mechanical, thermal or other energy sources. Electrospinning has numerous advantages over other approaches to produce ASDs. These advantages include extremely rapid drying speeds, ease of implentation, compatibility with a wide range of active ingredients (including those which are thermally labile), and the generation of products with large surface areas and high porosity. Furthermore, this technique exhibits the potential to create so-called 'fifth-generation' ASDs with nanostructured architectures, such as core/shell or Janus systems and their combinations. These advanced systems can improve dissolution behaviour and provide programmable drug release profiles. Additionally, the fiber components and their spatial distributions can be precisely controlled. Electrospun fiber-based ASDs can maintain an incorporated active ingredient in the amorphous physical form for prolonged periods of time because of their homogeneous drug distribution within the polymer matrix (typically they comprise solid solutions), and ability to inhibit molecular motion. These ASDs can be utilised to generate oral dosage forms for poorly water-soluble drugs, resulting in linear or multiple-phase release of one or more APIs. Electrospun ASDs can also be exploited as templates for manipulating molecular self-assembly, offering a bridge between ASDs and other types of dosage forms. This review addresses the development, advantages and pharmaceutical applications of electrospinning for producing polymeric ASDs. Material preparation and analysis procedures are considered. The mechanisms through which performance has been improved are also discussed.

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“…During optimization of the fiber properties, special attention should be paid for instance to the hydrophilicity of the fibers, fiber stability, and drug release profiles (in case of encapsulated compounds) 12 . Drug release and stability properties are often studied in vitro in water 19,20 , phosphate buffer 21 , phosphate-buffered saline (PBS) 8,[22][23][24][25][26][27][28][29][30][31][32][33] , or other similar buffers not containing specific physiologically occurring compounds 34,35 . Depending on the application of the electrospun fibers, they will be exposed to different physiological environments, which contain compounds such as bile salts, proteins, and salts.…”

Section: Introductionmentioning

confidence: 99%

Interactions between Surfactants in Solution and Electrospun Protein Fibers: Effects on Release Behavior and Fiber Properties

et al. 2016

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Intermolecular interaction phenomena occurring between endogenous compounds, such as proteins and bile salts, and electrospun compounds are so far unreported, despite the exposure of fibers to such biorelevant compounds when applied for biomedical purposes, e.g., tissue engineering, wound healing, and drug delivery. In the present study, we present a systematic investigation of how surfactants and proteins, as physiologically relevant components, interact with insulin-loaded fish sarcoplasmic protein (FSP) electrospun fibers (FSP-Ins fibers) in solution and thereby affect fiber properties such as accessible surface hydrophilicity, physical stability, and release characteristics of an encapsulated drug. Interactions between insulin-loaded protein fibers and five anionic surfactants (sodium taurocholate, sodium taurodeoxycholate, sodium glycocholate, sodium glycodeoxycholate, and sodium dodecyl sulfate), a cationic surfactant (benzalkonium chloride), and a neutral surfactant (Triton X-100) were studied. The anionic surfactants increased the insulin release in a concentration-dependent manner, whereas the neutral surfactant had no significant effect on the release. Interestingly, only minute amounts of insulin were released from the fibers when benzalkonium chloride was present. The FSP-Ins fibers appeared dense after incubation with this cationic surfactant, whereas high fiber porosity was observed after incubation with anionic or neutral surfactants. Contact angle measurements and staining with the hydrophobic dye 8-anilino-1-naphthalenesulfonic acid indicated that the FSP-Ins fibers were hydrophobic, and showed that the fiber surface properties were affected differently by the surfactants. Bovine serum albumin also affected insulin release in vitro, indicating that also proteins may affect the fiber performance in an in vivo setting.

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Mebeverine‐Loaded Electrospun Nanofibers: Physicochemical Characterization and Dissolution Studies

Cited by 47 publications

References 38 publications

Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis

Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Interactions between Surfactants in Solution and Electrospun Protein Fibers: Effects on Release Behavior and Fiber Properties

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