Mechanical and histological characterization of trachea tissue subjected to blast-type pressures

Butler, Benjamin J.; Bo, Chiara; Tucker, Andrew; Jardine, A. P.; Proud, W. G.; Williams, Alun; Brown, Katherine A.

doi:10.1088/1742-6596/500/18/182007

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…This type of tissue damage, arising from the pressure pulse shown in Fig. 2C, is consistent with previously reported observations of tracheal tissue subjected to blast-type pressures [9].…”

Section: Resultssupporting

confidence: 92%

“…Tissue explants of respiratory tissues are capable of maintaining many characteristics of in vivo physiology and cellular complexity in whole animals [10]. The shock tube system used in these studies enables one to tailor outputs to produce pressure loading that can be used to mimic features associated with scenarios that can result in injury patterns over a range of scales, from cells to whole animal models [7][8][9]. Our aim is to utilise these features to create meaningful, tissue-based models of mechanical trauma that can be used to study underlying tissue damage mechanisms associated with blast lung and ARDS.…”

Section: A B Cmentioning

confidence: 99%

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Use of a Shock Tube Platform in the Replication of Blast Lung Injury

et al. 2021

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War and asymmetrical conflicts are becoming increasingly prevalent in the modern world. Due to improvements in conflict medicine, survivable injuries are now more severe than they once were. Therefore, it is now more important than ever that there exist scientific and engineering methods for replicating wartime injuries in the context of the laboratory. We have developed one such method: a shock tube platform for testing ex vivo samples of the porcine respiratory system. Using this platform, we can, to some extent, simulate the pathophysiological consequences of blast lung. This is a condition commonly present in victims of explosive blasts, both those due to typical armaments and Improvised Explosive Devices (IEDs). Presented here are the results of experiments conducted using porcine bronchiole tissue as ex vivo organ cultures. Data presented show epithelial damage, consistent with known trauma-induced cell injury that can lead to acute respiratory distress syndrome (ARDS).

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“…This type of tissue damage, arising from the pressure pulse shown in Fig. 2C, is consistent with previously reported observations of tracheal tissue subjected to blast-type pressures [9].…”

Section: Resultssupporting

confidence: 92%

Section: A B Cmentioning

confidence: 99%

Use of a Shock Tube Platform in the Replication of Blast Lung Injury

et al. 2021

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“…Thus, it is essential to develop most reliable and flexible experimental methods to illustrate mechanical behaviour of soft materials at different intermediate rates of strain. [14] and liver tissues [15], bovine muscles [16], porcine muscles [1], bovine kidney tissue [3], porcine white adipose tissue [4], porcine trachea [17], EPDM rubber [10], polyurea [5] and gelatin bio-material [6] under dynamic compressive loading conditions, while bovine tendon [7], pig skin [8] This review summarizes important issues related with the application of SHPB in the characterization of soft tissues and soft materials. These issues are weak transmitted signals, constant rate of deformation, uniform loading on the specimen, specimen gripping methods and inertia effects.…”

Section: Intermediate Strain Rate Testingmentioning

confidence: 99%

Review of Experimental Techniques used to Study the Mechanical Behaviour of Biological Soft Tissues

Kadhane

Warhatkar

2017

Proceedings of the International Conference on Communication and Signal Processing 2016 (ICCASP 2016)

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Abstract:This review is intended to highlight and discuss the various experimental techniques used to obtain the mechanical behavior of soft tissues at varying strain rates. A variety of techniques used to obtain the mechanical properties of soft tissues and soft materials from low to intermediate and high rates of strain are summarized. These techniques include quasi-static, intermediate and dynamic strain rate setups. Split Hopkinson Pressure Bar (SHPB) technique with some modifications is commonly used for testing soft materials at high strain rates up to 10 4 s -1 . Article searches were performed on impact biomechanics, orthopaedic and biomechanical publications in databases: PubMed, Scopus, ScienceDirect, Compendex, MEDLINE and EMBASE. The discrepancies on the use of conventional SHPB in the dynamic soft tissues testing were highlighted. This review explains the use of conventional SHPB technique for the characterization of soft tissues under compressive and tensile loading. The discrepancies in existing literature emphasize the need for additional research into the development of SHPB for dynamic testing of soft tissues under both compressive and tensile loading. This review suggests requirement of an integrated SHPB setup with necessary modifications in striker bar loading mechanism and specimen clamping attachment for dynamic testing of soft tissues under compressive as well as tensile loading.

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“…Over a decade, SHPB with low impedance metallic bars has been widely used to investigate the dynamic stress-strain response of soft tissues under compressive loading and such response has been found to very different form the quasi-static response. The compressive stress-strain responses of bovine soft tissues such as kidney tissue [13], liver tissue [14], brain tissue [15]; porcine soft tissues such as liver tissue [16], adipose tissue [17], trachea tissue [18] and lung tissue [19] have been recently studied over wide range of strain rates using modified versions of low impedance metallic SHPB. The compressive mechanical response of porcine muscle [20] and bovine muscle [21] using low impedance metallic bars and PMHS muscle [22] and goat muscle [23] using polymeric SHPB has been studied systematically at high strain rates.…”

Section: Introductionmentioning

confidence: 99%