Mechanical properties and biocompatibility of titanium with a high oxygen concentration for dental implants

Luo, Huiwen; Wu, Yulu; Diao, Xiaoou; Shi, Wendi; Feng, Fan; Qian, Fei; Umeda, Junko; Kondoh, Katsuyoshi; Xin, Haitao; Shen, Jianghua

doi:10.1016/j.msec.2020.111306

Cited by 21 publications

(7 citation statements)

References 54 publications

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“…Findings from our in vitro experiments showed clearly that the surface structure and the composition of S_TiNb discs, as well as S-TiCp discs, have no effect on cellular attachment, adherence, proliferation, and survival of SaOs-2 cells as compared to polystyrene surfaces, implying that smooth titanium-niobium alloys may be used safely in dental implants without complications. These results are consistent with findings reported earlier with respect to the compatibility of S_TiCp [ 9 , 25 , 30 , 31 , 32 ]. Recent studies have highlighted the biocompatibility of titanium-niobium alloys on various cell lines such as fibroblasts, osteoblasts, mesenchymal stem cells [ 33 , 34 , 35 , 36 ].…”

Section: Discussionsupporting

confidence: 93%

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility

et al. 2022

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Titanium dental implants have common clinical applications due to their biocompatibility, biophysical and biochemical characteristics. Although current titanium is thought to be safe and beneficial for patients, there are several indications that it may release toxic metal ions or metal nanoparticles from its alloys into the surrounding environment, which could lead to clinically relevant complications including toxic reactions as well as immune dysfunctions. Hence, an adequate selection and testing of medical biomaterial with outstanding properties are warranted. This study was designed to explore the biocompatibility of smooth titanium-niobium alloy (S_TiNb) versus smooth titanium commercially pure (S_TiCp)—a reference in implantology. All experiments were performed in vitro using human osteoblast-like SaOs-2 and monocyte THP-1 cell lines as models. Cell adhesion and growth morphology were determined by scanning electron microscopy, while cell viability was evaluated using WST-1 assay. Because niobate anions or niobium nanoparticles can be released from implants during biomaterial-cell interaction, potential immunotoxicity of potassium niobate (KNbO3) salt was evaluated by examining both metabolic activity and transcriptomic profiling of treated THP-1 monocytes. The main findings of this study are that S_TiCp and S_TiNb discs do not show an impact on the proliferation and viability of SaOs-2 cells compared to polystyrene surfaces, whereas a significant decrease in THP-1 cells’ viability and metabolic activity was observed in the presence of S_TiNb discs compared to the control group. However, no significant changes were found neeither at the metabolic activity nor at the transcriptomic level of THP-1 monocytes exposed to KNbO3 salt, suggesting that niobium has no effect on the immune system. Overall, these data imply a possible toxicity of S_TiNb discs toward THP-1 cells, which may not be directly related to niobium but perhaps to the manufacturing process of titanium- niobium alloy. Thus, this limitation must be overcome to make titanium alloy an excellent material for medical applications.

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Section: Discussionsupporting

confidence: 93%

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility

et al. 2022

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“…To refine Ti grains to a nanometric size, microcrystalline Ti (rod diameter = 50 mm) was subjected to multistage hydrostatic extrusion (HE) with an equivalent strain of 3.7. This large plastic deformation process reduced the Ti rod diameter to 8 mm, which is sufficient for the fabrication of dental replacements [ 3 , 42 ]. The methodology of HE was optimized at the Institute of High Pressure Physics of the Polish Academy of Sciences, and a detailed description of it is provided in [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

“…Currently, pure Ti is one of the most commonly used materials in commercial dental solutions proposed by leading implant manufacturers, such as Strauman TM and Nobel Biocare TM [ 2 ]. This popularity is due to its biocompatibility and high corrosion resistance combined with relatively low stiffness [ 3 , 4 , 5 , 6 ]. The success of dental procedures is governed not only by the biomaterial selected but also by the quality of bone tissue at the implantation site [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

How Streptococcus mutans Affects the Surface Topography and Electrochemical Behavior of Nanostructured Bulk Ti

et al. 2022

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The metabolization of carbohydrates by Streptococcus mutans leads to the formation of lactic acid in the oral cavity, which can consequently accelerate the degradation of dental implants fabricated from commercially available microcrystalline Ti. Microstructure influences surface topography and hence interaction between bacteria cells and Ti surfaces. This work offers the first description of the effect of S. mutans on the surface topography and properties of nanostructured bulk Ti, which is a promising candidate for modern narrow dental implants owing to its superior mechanical strength. It was found that S. mutans incubation resulted in the slight, unexpected decrease of surface nanoroughness, which was previously developed owing to privileged oxidation in areas of closely spaced boundaries. However, despite the changes in nanoscale surface topography, bacteria incubation did not reduce the high level of protection afforded by the oxide layer formed on the nanostructured Ti surface. The results highlight the need–hitherto ignored–to consider Ti microstructure when analyzing its behavior in the presence of carbohydrate-metabolizing bacteria.

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“…Titanium (Ti) and Ti-based alloys generally present desirable mechanical characteristics, corrosion resistance, and biocompatibility [1][2][3]. Titanium-based alloys have been extensively used in the last four decades to create implant elements and medical tools like prostheses or dental implants.…”

Section: Introductionmentioning

confidence: 99%

Corrosion-Resistance Analysis of HA Layer Deposited through Electrophoresis on Ti4Al4Zr Metallic Substrate

et al. 2021

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An alloy surface with possible applications in the medical field, Ti4A14Zr, was improved through the deposition of a thin hydroxyapatite (HA) layer. In this paper, we analyzed the growth of a HA layer through electrophoresis and the corrosion resistance of the metallic sample covered with the ceramic layer. The substrate surface was processed via chemical procedures before the HA deposition. The state of the metallic surface and that of the layer of HA were investigated using scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) analysis of the chemical composition. The results indicate a high increase in the corrosion resistance associated with the ceramic layer compared to the metallic basic layer. Moreover, the analysis revealed the formation of a homogeneous TiO2 layer on the surface of the metallic substrate. The titanium oxide layer identified by SEM–EDS and confirmed by EIS was very homogeneous and resistant, with a compact microstructural appearance and submicron dimension. The layer composed of TiO2 and HA provided good corrosion protection.

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Mechanical properties and biocompatibility of titanium with a high oxygen concentration for dental implants

Cited by 21 publications

References 54 publications

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility

How Streptococcus mutans Affects the Surface Topography and Electrochemical Behavior of Nanostructured Bulk Ti

Corrosion-Resistance Analysis of HA Layer Deposited through Electrophoresis on Ti4Al4Zr Metallic Substrate

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