Mechanical properties and in vitro biocompatibility of porous zein scaffolds

Gong, Shengju; Wang, Huajie; Sun, Qingshen; Xue, Shengjun; Wang, Jin‐Ye

doi:10.1016/j.biomaterials.2006.02.019

Cited by 144 publications

(124 citation statements)

References 28 publications

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“…Heparin-loaded zein microsphere film and its degraded product had better biocompatibility when they were used to culture human umbilical vein endothelial cells . Gong (Gong et al, 2006) further demonstrated that zein scaffold can promote rat bone marrow stromal cell adhesion, growth, and differentiation, suggesting that zein protein possesses good histocompatibility (Wang et al, 2007). Here zein as a scaffold material was studied for periodontal tissue engineering.…”

Section: Discussionmentioning

confidence: 99%

The Use of Zein and Shuanghuangbu for Periodontal Tissue Engineering

Chen

et al. 2010

Int J Oral Sci

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Aim Tissue engineering is a promising area with a broad range of applications in the fields of regenerative medicine and human health. The emergence of periodontal tissue engineering for clinical treatment of periodontal disease has opened a new therapeutic avenue. The choice of scaffold is crucial. This study was conducted to prepare zein scaffold and explore the suitability of zein and Shuanghuangbu for periodontal tissue engineering. Methodology A zein scaffold was made using the solvent casting/particulate leaching method with sodium chloride (NaCl) particles as the porogen. The physical properties of the zein scaffold were evaluated by observing its shape and determining its pore structure and porosity. Cytotoxicity PDLCs. Altogether, these findings provide the basis for in vivo testing on animals.

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Section: Discussionmentioning

confidence: 99%

The Use of Zein and Shuanghuangbu for Periodontal Tissue Engineering

Chen

et al. 2010

Int J Oral Sci

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“…The combined mechanical properties and biocompatibility of the fabricated Fe-Mn-based temporary implants determine whether they are adequate to be implanted safely in the human body [40]. In general, the mechanical properties degrade along with the increase of implantation time due to the aggressive environment in the human body.…”

Section: Biocompatibility Of the Sintered Fe-mn-based Alloysmentioning

confidence: 99%

Effect of Immersion in Simulated Body Fluid on the Mechanical Properties and Biocompatibility of Sintered Fe–Mn-Based Alloys

Hodgson

Cao

2016

Metals

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Fe-Mn-based degradable biomaterials (DBMs) are promising candidates for temporary implants such as cardiovascular stents and bone fixation devices. Identifying their mechanical properties and biocompatibility is essential to determine the feasibility of Fe-Mn-based alloys as DBMs. This study presents the tensile properties of two powder metallurgical processed Fe-Mn-based alloys (Fe-28Mn and Fe-28Mn-3Si, in mass percent) as a function of immersion time in simulated body fluid (SBF). In addition, short-term cytotoxicity testing was performed to evaluate the in vitro biocompatibility of the sintered Fe-Mn-based alloys. The results reveal that an increase in immersion duration deteriorated the tensile properties of both the binary and ternary alloys. The tensile properties of the immersed alloys were severely degraded after being soaked in SBF for ≥45 days. The ion concentration in SBF released from the Fe-28Mn-3Si samples was higher than their Fe-28Mn counterparts after 7 days immersion. The preliminary cytotoxicity testing based on the immersed SBF medium after 7 days immersion suggested that both the Fe-28Mn-3Si and Fe-28Mn alloys presented a good biocompatibility in Murine fibroblast cells.

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“…As a major storage protein, Zein is composed of about 45-50% of the total protein in corn. It was demonstrated to be a promising biomaterial with good biocompatibility for tissue engineering [18][19][20][21] and was also used for the preparation of microspheres for constant release of drugs. 22) To be a promising drug delivery system, it is important to explore the pharmacokinetics of drug-loaded Zein in situ gel.…”

Section: Doxorubicin-loaded Zein In Situ Gel For Interstitial Chemothmentioning

confidence: 99%

Doxorubicin-Loaded Zein <i>in Situ</i> Gel for Interstitial Chemotherapy

Cao

Geng

et al. 2012

CHEMICAL & PHARMACEUTICAL BULLETIN

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A novel drug delivery system of doxorubicin (DOX)-loaded Zein in situ gel for interstitial chemotherapy was investigated in this study. The possible mechanisms of drug release were described according to morphological analysis by optical microscopy and scanning electronic microscope (SEM). In vitro and in vivo anti-tumor activity studies showed that DOX-loaded Zein in situ gel was superior to DOX solution. Local pharmacokinetics in tumor tissue was studied by quantitative analysis with confocal laser scanning microscopy (CLSM) combined with microdialysis technology. A pharmacokinetics mathematical model of DOX-loaded Zein in situ gel in tumors was then built.

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Mechanical properties and in vitro biocompatibility of porous zein scaffolds

Cited by 144 publications

References 28 publications

The Use of Zein and Shuanghuangbu for Periodontal Tissue Engineering

The Use of Zein and Shuanghuangbu for Periodontal Tissue Engineering

Effect of Immersion in Simulated Body Fluid on the Mechanical Properties and Biocompatibility of Sintered Fe–Mn-Based Alloys

Doxorubicin-Loaded Zein <i>in Situ</i> Gel for Interstitial Chemotherapy

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