Mechanical properties of anodized TiNbSn alloy for biomedical applications

Hatakeyama, Masahiko; Masahashi, Naoya; Michiyama, Yasuhiro; Inoue, Hiroyuki; Hanada, Shuji

doi:10.1016/j.msea.2021.141898

Cited by 9 publications

(9 citation statements)

References 70 publications

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“…Since high voltage is applied, there is a high possibility of embrittlement of the oxide film, but sodium tartrate is effective in suppressing such embrittlement ( Masahashi et al, 2021 ). A study of anodic oxidation of TiNbSn alloy with sodium tartrate has reported no change in Young’s modulus after anodic oxidation ( Hatakeyama et al, 2021 ). Thus, TiNbSn alloy is a promising biomaterial in the field of orthopaedic prosthesis.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Kurishima

Mori

Inoue

et al. 2022

Front. Bioeng. Biotechnol.

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In this study, we anodized a TiNbSn alloy with low Young’s modulus in an electrolyte of sodium tartrate with and without hydrogen peroxide (H2O2). The photo-induced characteristics of the anodized alloy were analyzed for crystallinity and electrochemical conditions with comparisons to the effect with the addition of H2O2. The antibacterial activity was evaluated using methicillin-resistant Staphylococcus aureus and other pathogenic bacteria according to ISO 27447, and time decay antibacterial tests were also conducted. The anodized oxide had a porous microstructure with anatase- and rutile-structured titanium dioxide (TiO2). In contrast, the peaks of rutile-structured TiO2 were accelerated in the anodized TiNbSn alloy with H2O2. The formation of hydroxyl radicals and methylene blue breaching performance under ultraviolet irradiation was confirmed in the anodic oxide on TiNbSn alloy with and without H2O2. The anodic oxide on TiNbSn alloy had a robust antibacterial activity, and no significant difference was detected with or without H2O2. We conclude that anodized TiNbSn alloy with sodium tartrate electrolyte may be a functional biomaterial with a low Young’s modulus and an antibacterial function.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Kurishima

Mori

Inoue

et al. 2022

Front. Bioeng. Biotechnol.

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“…The primary diffraction of the rutile oxide corresponds to the (101) plane, which is different from that of the reference (ICDD 01-073-2224). In addition, the results are different from the anodized oxide prepared in the sodium tartrate electrolyte, where a major peak was observed corresponding to the 101 plane [ 27 ].…”

Section: Resultsmentioning

confidence: 89%

“…In addition, the crystallinity and thickness of the resulting TiO 2 coating may also change if the base material of the titanium alloy is changed. In a previous study, the comparison of the anodic oxidation of TiNbSn and Ti6Al4V alloys in sodium tartrate electrolytes showed that the anodized TiNbSn alloy had better wear resistance [ 26 , 27 ]. Different anodic oxidation methods may need to be considered for each base metal to optimize the results.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Properties of TiNbSn Alloys Anodized in a Sulfuric Acid Electrolyte

et al. 2023

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TiNbSn alloy is a high-performance titanium alloy which is biosafe, strong, and has a low Young’s modulus. TiNbSn alloy has been clinically applied as a material for orthopedic prosthesis. Anodized TiNbSn alloys with acetic and sulfuric acid electrolytes have excellent biocompatibility for osseointegration. Herein, TiNbSn alloy was anodized in a sulfuric acid electrolyte to determine the antimicrobial activity. The photocatalytic activities of the anodic oxide alloys were investigated based on their electronic band structure and crystallinity. In addition, the cytotoxicity of the anodized TiNbSn alloy was evaluated using cell lines of the osteoblast and fibroblast lineages. The antimicrobial activity of the anodic oxide alloy was assessed according to the ISO 27447 using methicillin-susceptible Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Escherichia coli. The anodic oxide comprised rutile and anatase titanium dioxide (TiO2) and exhibited a porous microstructure. A well-crystallized rutile TiO2 phase was observed in the anodized TiNbSn alloy. The methylene blue degradation tests under ultraviolet illumination exhibited photocatalytic activity. In antimicrobial tests, the anodized TiNbSn alloy exhibited robust antimicrobial activities under ultraviolet illumination for all bacterial species, regardless of drug resistance. Therefore, the anodized TiNbSn alloy can be used as a functional biomaterial with low Young’s modulus and excellent antimicrobial activity.

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“…The photocatalytic and antibacterial performances of anodized TiNbSn alloys prepared in an electrolyte of sodium tartrate acid have been studied [ 68 , 69 , 70 , 71 ]. In the development of antibacterial metals, antibacterial metal ions, such as silver and copper, and antibacterial agents, such as iodine and vancomycin, have been used [ 72 , 73 , 74 , 75 ].…”

Section: Photocatalytic Activity Of Anodized Tinbsn Alloymentioning

confidence: 99%

“…The stem used in the clinical trial was not anodized, and it is necessary to investigate the possibility of high-quality anodized TiO 2 in large-scale products such as femoral stem prostheses in the future. Anodization of TiNbSn alloys also imparts a higher exfoliation strength and wear resistance than the Ti6Al4V alloy [ 70 ]; therefore, the anodized TiNbSn alloy may also be useful for preventing corrosion in orthopedic implants. Anodized TiNbSn alloys are promising high-performance orthopedic implant materials with high bone affinity and antibacterial properties without compromising their inherently low Young’s modulus.…”

Section: Future Research Developmentmentioning

confidence: 99%

A Review of Anodized TiNbSn Alloys for Improvement in Layer Quality and Application to Orthopedic Implants

2022

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Titanium alloys are useful for application in orthopedic implants. However, complications, such as prosthetic infections and aseptic loosening, often occur after orthopedic devices are implanted. Therefore, innovation in surface modification techniques is essential to develop orthopedic materials with optimal properties at the biomaterial–bone interface. In this review, we present recent research on the improvement in the osteoconductivity and antibacterial effect of the Ti-33.6% Nb-4% Sn (TiNbSn) alloy by anodic oxidation and other related studies. TiNbSn alloys are excellent new titanium alloys with a low Young’s modulus, high tensile strength, and with gradient functional properties such as a thermally adjustable Young’s modulus and strength. Titanium dioxide (TiO2), when obtained by the anodic oxidation of a TiNbSn alloy, improves bone affinity and provides antibacterial performance owing to its photocatalytic activity. The safety of TiO2 and its strong bonding with metal materials make its method of preparation a promising alternative to conventional methods for improving the surface quality of orthopedic implants. Implementing anodization technology for TiNbSn alloys may alleviate orthopedic surgery-related complications, such as loosening, stress shielding, and infection after arthroplasty.

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Mechanical properties of anodized TiNbSn alloy for biomedical applications

Cited by 9 publications

References 70 publications

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Antimicrobial Properties of TiNbSn Alloys Anodized in a Sulfuric Acid Electrolyte

A Review of Anodized TiNbSn Alloys for Improvement in Layer Quality and Application to Orthopedic Implants

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