Mechanical strength in rat skin incisional wounds treated with fibrin sealant

Jørgensen, Peter; Jensen, Katrine; Andreassen, B

doi:10.1097/00006534-198809000-00090

Cited by 4 publications

(5 citation statements)

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“…Although they could not replace suture itself, when applied to primary skin wound closure, the glues developed significant tensile strength within 10 min. Other studies demonstrated that fibrin sealant provided mechanical strength in the first day of wound healing in which the wound possesses little independent mechanical strength (Jorgensen et al, 1987; Scardino et al, 1999). The increase of tensile strength at 72 h in all the groups indicated that incision was not held by the fibrin glues but by the natural healing mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Two Fibrin Glues in Anastomoses and Skin Closure

Park

Kim

Lee

et al. 2002

Journal of Veterinary Medicine Series A

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To control intra-operative haemorrhage, fibrin glues are preferred by many surgeons because of their biological advantages and convenience of application. Manufacturers have developed a few kinds of fibrin glues with a little difference in their composition. This study was to compare the effectiveness of two commercially available fibrin glues; Greenplast (Green Cross P. D. Company, Yongin, Korea) and Tisseel (Baxter-Immuno AG, Vienna, Austria). They were applied experimentally to several kinds of surgery in dogs - renal vessel anastomosis, partial splenectomy, intestinal anastomosis and incision skin wound - and evaluated for their haemostatic and adhesive effects. When the two glues were applied in renal vessel anastomosis, the amount of haemorrhage in artery and vein decreased significantly. They also decreased the haemorrhage in partial splenectomy. At 10 min after application of the glues to an incision skin wound, the tensile strengths developed were significantly higher than that of control. The present study indicates that two-component fibrin glues have a haemostatic effect as a mechanical barrier in renal vessel anastomosis and an adhesive effect in the early stage of incision skin wound closure, and the two glues have similar effects with no complications.

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Section: Discussionmentioning

confidence: 99%

Comparison of Two Fibrin Glues in Anastomoses and Skin Closure

Park

Kim

Lee

et al. 2002

Journal of Veterinary Medicine Series A

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“…During the first few days of wound healing the development of mechanical strength is very poor and is mainly attributed to the fibrin deposited (251,252). After three or four days however, the collagen will be deposited in substantial amounts to convey mechanical strength to the wound (180,232,253,254).…”

Section: Mechanical Strength Development Of Healing Tissuementioning

confidence: 99%

Growth Hormone, Skin and Wound Healing—experimental studies in the rat

Jørgensen

1997

APMIS

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Cop y r i g h t0 A P M I S 199 7 &PMUS I S S N 0 9 0 3 -4 6 5 x I S B N 8 7-16-156 78-1 ACKNOWLEDGEMENTS This thesis is based on experimental works performed at the Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Denmark during my employment as a research fellow. It was a fascinating and most inspiring time and I wish to convey my heartiest thanks to all members of the staff at the institute.Some specific people, however must be mentioned here. Above all special thoughts go to my two friends Associate Professor Troels Torp Andreassen and Associate Professor Hans Oxlund, D.M.Sc.,who introduced me into the fields of collagen and wound healing. With enormous knowledge, patience and perseverance they were ready to discuss and give advice at any time of the day. And they were both able to look far beyond the limited walls of a scientific institute and consider the world in a broader sense. Dr. Bue Bak, D.M.Sc., withwhom I was lucky to share my office was an example to any scientist as he always sticked to the line in the search for his goals. Professor Hans Orskov, D.M.Sc., Hospital has been a great inspirator due to his enormous knowledge on growth hormone and engagement in any aspect of the exploration of this fascinating molecule.

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“…1 Fibrin acts as a hemostatic barrier, adhering to surrounding tissue and cells, and as a scaffolding for migrating fibroblasts. [1][2][3][4][5][6][7] There are several commercial products in Europe but none in the United States due to the current regulatory stance against pooled plasma blood products. 2 In recent years, considerable research has been performed with fibrin sealants in various fields of surgery as an alternative to numerous common surgical techniques for attaining hemostasis, fixation, sealing of wounds, and enhanced wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…2,4,9 Cyanoacrylates, including superglue and methylmethacrylate, are strong and easy to use, but they are topical agents only. 3 Fibrin sealants have also been found to greatly decrease operating time 8,14 and have been reported to improve wound healing and the final scar. 4 Problems with cell toxicity and foreign body reaction have outweighed the superior adhesive and coadhesive properties of cyanoacrylates.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of fibrin sealants in cutaneous wound closure

Scardino¹,

Swaim²,

Morse³

et al. 1999

J. Biomed. Mater. Res.

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Human fibrin sealant (HFS) and bovine fibrin sealant (BFS) were delivered as preformulated fibrinogen–thrombin mixtures that are light activated. These formulations were evaluated in the healing of incised cutaneous wounds in beagle dogs. Four groups were differentiated by sealant type and study duration with group: BFS for 10 days, HFS for 10 days, BFS for 30 days, and HFS for 30 days. Healing was evaluated by noting incidences of open wounds, laser Doppler perfusion imaging (LDPI), planimetry, breaking strength, and histopathology. In the absence of tension, both sealants tended to hold wound edges together; however, HFS tended to be better than its controls and BFS. Both sealants augmented suture closure, necessitating fewer sutures for wound closure. At 5 and 30 days BFS wounds had more perfusion than HFS wounds, indicating more inflammation. At 10 and 30 days BFS wounds had larger scar areas than their controls, while scar areas of HFS wounds were smaller than either BFS wounds or controls. Breaking strengths indicated that HFS wounds were stronger than their controls and BFS wounds. Histologically, mild to moderate chronic‐active inflammation was observed in wounds receiving either sealant, and this persisted longer in BFS wounds. Overall, HFS had positive qualities, thus showing potential for functional and cosmetic wound closure. © 1999 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 48: 315–321, 1999

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Mechanical strength in rat skin incisional wounds treated with fibrin sealant

Cited by 4 publications

References 0 publications

Comparison of Two Fibrin Glues in Anastomoses and Skin Closure

Comparison of Two Fibrin Glues in Anastomoses and Skin Closure

Growth Hormone, Skin and Wound Healing—experimental studies in the rat

Evaluation of fibrin sealants in cutaneous wound closure

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