Mechanically robust, biocompatible, and durable PHEMA-based hydrogels enabled by the synergic effect of strong intermolecular interaction and suppressed phase separation

Wang, Yi; Ouyang, Hongyan; Xie, Yuanjie; Jiang, Yinan; Zhao, Lijuan; Peng, Wanliu; Wu, Junliang; Bao, Ji; Liu, Yong; Wu, Jinrong

doi:10.1016/j.polymer.2022.125083

Cited by 14 publications

(8 citation statements)

References 25 publications

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“…These hydrogels were tested in vivo on 6 SD rats (12 weeks old), embedding samples subcutaneously and on porcine auricular cartilage replacement experiments. In addition, cell viability was evaluated by in vitro assays, obtaining results between 79–85% after 24 h cultures of each system, with no significant variations among them [ 44 ]. Kim et al (2019) proposed the formation of a non-swellable and cytocompatible interpenetrated polymer network (IPN) between chemically cross-linked pHEMA and ionically cross-linked alginate, obtaining a synergistic effect that enhanced stiffness and toughness.…”

Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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“…A similar hydrogen bond association behavior was also reported in poly(2-hydroxyethyl methacrylate- co -maleic acid)-Fe 3+ hydrogel. 36 It is apparent that the mechanical properties of bicontinuous hydrogel can be tuned effectively by changing the molar ratio of monomers, total monomer amount, and crosslinking agent content.…”

Section: Resultsmentioning

confidence: 99%

An impact resistant hydrogel enabled by bicontinuous phase structure and hierarchical energy dissipation

Qiu

Liu

et al. 2023

J. Mater. Chem. B

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“…In addition, after introducing MA units, the scattered intensity and signal decrease remarkably ( Figure 2 c,d). This shows that the aggregation of the PHEMA chains is significantly decreased by hydrogen-bonding interactions between the MA units and HEMA units [ 26 , 27 ], resulting in a homogeneous structure. With the MA content increasing, the scattering intensity and signal of the PHMx hydrogels decrease gradually, indicating that the phase separation is gradually inhibited and the network uniformity of the PHMx hydrogels is gradually improved.…”

Section: Resultsmentioning

confidence: 99%

“…Based on the time-temperature equivalence principle, the storage modulus G’, loss modulus G”, and loss factor tanδ curves were shifted at different temperatures to obtain the main curves of the rheological wide frequency range with a reference temperature of 10 °C. The horizontal displacement factor a T of the time-temperature superposition conforms to the Arrhenius equation [ 27 , 30 ]:

…”

Section: Methodsmentioning

confidence: 99%

Compliant, Tough, Anti-Fatigue, Self-Recovery, and Biocompatible PHEMA-Based Hydrogels for Breast Tissue Replacement Enabled by Hydrogen Bonding Enhancement and Suppressed Phase Separation

Ouyang

Xie

et al. 2022

Gels

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Although hydrogel is a promising prosthesis implantation material for breast reconstruction, there is no suitable hydrogel with proper mechanical properties and good biocompatibility. Here, we report a series of compliant and tough poly (hydroxyethyl methacrylate) (PHEMA)-based hydrogels based on hydrogen bond-reinforcing interactions and phase separation inhibition by introducing maleic acid (MA) units. As a result, the tensile strength, fracture strain, tensile modulus, and toughness are up to 420 kPa, 293.4%, 770 kPa, and 0.86 MJ/m3, respectively. Moreover, the hydrogels possess good compliance, where the compression modulus is comparable to that of the silicone breast prosthesis (~23 kPa). Meanwhile, the hydrogels have an excellent self-recovery ability and fatigue resistance: the dissipative energy and elastic modulus recover almost completely after waiting for 2 min under cyclic compression, and the maximum strength remains essentially unchanged after 1000 cyclic compressions. More importantly, in vitro cellular experiments and in vivo animal experiments demonstrate that the hydrogels have good biocompatibility and stability. The biocompatible hydrogels with breast tissue-like mechanical properties hold great potential as an alternative implant material for reconstructing breasts.

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Mechanically robust, biocompatible, and durable PHEMA-based hydrogels enabled by the synergic effect of strong intermolecular interaction and suppressed phase separation

Cited by 14 publications

References 25 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

An impact resistant hydrogel enabled by bicontinuous phase structure and hierarchical energy dissipation

Compliant, Tough, Anti-Fatigue, Self-Recovery, and Biocompatible PHEMA-Based Hydrogels for Breast Tissue Replacement Enabled by Hydrogen Bonding Enhancement and Suppressed Phase Separation

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