Mechanism of action of bio-inspired nanosilver particles

Abstract

Nanotechnology is gaining prime importance in the present era due to modeling of metals in nanoparticles (NPs) by biological methods, but nowadays, researchers are designing the exact mode of action of nanomaterials on plants. NPs are fabricated by different physical and chemical methods, but biological methods are preferred due to their simplicity and non-toxic nature. The current development of biomimetic NP synthesis is a more reliable, economically favorable and eco-friendly method for the treatment of different diseases. NPs fabricated by traditional methods have shown a lot of demerits, so the green route to the formation of metallic NPs is advantageous compared to the use of microbes. Secondary metabolites in the plant have active chemical constituents which can act as capping and reducing agents, thereby enhancing the rate of reduction and stabilizations of NPs. In this review, a major focus is given to biogenic silver NPs’ mechanism of action toward cancer and microbes.

التخليق الحيوي لجسيمات الفضة النانوية باستخدام مستخلصات الشاي الأخضر

“…Although there are many metals in nature, they are manufactured on a large scale by using a few of them such as gold, silver, palladium and platinum in the form of nanostructures 5 , among the above meta metals, silver nanoparticles have attracted much attention due to their unique properties for use in various applications including pharmacology, agriculture, water detoxification, air purification, textile industries and as a catalyst in oxidation reactions 6 . In addition, the important properties of its antibacterial activity against a wide range of bacteria without any toxicity to animal cells 7 .…”

A Proposed Insight into the Anti-viral Potential of Silver Nanoparticles against Novel Coronavirus Disease (COVID-19)

“…The mechanism of the toxic effect of nanosilver on bacterial cells and viruses is possible in several ways: interaction and damages to cell membranes, cellular uptake, reactive oxygen species (ROS) production, interaction with and damage to cellular proteins, binding and damages to cellular DNA and RNA repair [28]. In the case of coronavirus, there are 3 possible directions of nanosilver exposure: membrane destruction, RNA destruction and spike protein damage [29]. The effectiveness of each type of toxic effect of nanosilver on coronavirus has yet to be determined in the course of numerous experiments, the basis for which will be models of the mechanism of action.…”

Computed Quantum Chemical Modeling of the Effect of Nanosilver on Coronavirus COVID-1

“…The mechanism of toxic action of nanosilver on bacterial cells and viruses is possible in several ways: interaction and damages to cell membranes, cellular uptake, reactive oxygen species (ROS) production, interaction with and damage to cellular proteins, binding and damages to cellular DNA and RNA repair [43]. In the case of coronavirus, there may be 3 directions of nanosilver exposure: membrane damage, RNA disintegration, and spike protein destruction [44]. The effectiveness of each type of toxic effect of nanosilver on coronavirus has yet to be determined in numerous experiments, which will be based on models of the mechanism of action.…”