2019
DOI: 10.1155/2019/5747298
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Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells

Abstract: Osteoporosis, femoral head necrosis, and congenital bone defects are orthopedic disorders characterized by reduced bone generation and insufficient bone mass. Bone regenerative therapy primarily relies on the bone marrow mesenchymal stem cells (BMSCs) and their ability to differentiate osteogenically. Icariin (ICA) is the active ingredient of Herba epimedii, a common herb used in traditional Chinese medicine (TCM) formulations, and can effectively enhance BMSC proliferation and osteogenesis. However, the under… Show more

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Cited by 41 publications
(41 citation statements)
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References 137 publications
(169 reference statements)
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“…Icariin ( 2-(4’-methoxyphenyl)-3-rhamnose-5-hydroxyl-7-glucoside-8-(3’-methyl- 2-butylene)- 4-chromanone), a flavonoid with rhamnose as a ligand, promotes bone marrow derived mesenchymal stem cells proliferation, growth factors and migration. 50 …”
Section: Discussionmentioning
confidence: 99%
“…Icariin ( 2-(4’-methoxyphenyl)-3-rhamnose-5-hydroxyl-7-glucoside-8-(3’-methyl- 2-butylene)- 4-chromanone), a flavonoid with rhamnose as a ligand, promotes bone marrow derived mesenchymal stem cells proliferation, growth factors and migration. 50 …”
Section: Discussionmentioning
confidence: 99%
“…As the previous reports showed, BMSCs are a type of stem cell with specialization potentials, which can be differentiated into various types of cells, including osteoblasts, adipocytes, chondrocytes, myocytes and neurocytes [38]. In bone microenvironment, osteoblast cells are mainly derived from BMSCs, and osteoblasts are responsible for bone development [39]. Therefore, the biological functions of BMSCs are vital for the homeostasis of bone.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to promoting osteogenic differentiation of MSCs into osteoblasts, Icariin and Purmorphamine inhibit bone resorption by suppressing osteoclastogenesis and the bioactivity of the osteoclasts [ 40 , 41 ]. For diseases such as osteoporosis resulting from excessive bone resorption by osteoclasts, drugs such as Purmorphamine and Icariin could be utilized in potential treatments [ 42 , 43 ]. Although both drugs Icariin and Purmorphamine promote osteogenesis, the results of this study suggest that Icariin is more effective.…”
Section: Discussionmentioning
confidence: 99%