Mechanism of action of insecticidal secondary metabolites of plant origin

Essential oils and their components as an alternative in the control of mosquito vectors of disease

“…La primera complicación se debe a que es difícil determinar los mecanismos de acción de un producto que no es una sustancia pura, sino una mezcla de varios componentes, ya que todas las interacciones entre los compuestos pueden influir en la actividad (131).…”

Aproximación al estudio del daño oxidativo causado por larvicidas naturales y temefos sobre proteomas de larvas del mosquito Aedes aegypti

“…Una ventaja de los extractos crudos de plantas frente a los compuestos sintéticos, es que la acción insecticida es ejercida por una mezcla de varios metabolitos con diferentes modos de acción, lo cual reduce el riesgo de aparición de resistencia por parte de los mosquitos (7). Sin embargo, la caracterización de estos mecanismos de acción para la completa caracterización de la actividad biológica supone un verdadero reto científico.…”

Secondary Metabolism as a Measurement of Efficacy of Botanical Extracts: The Use of Azadirachta indica (Neem) as a Model

“…The growing demand for natural products has been intensified in the past decades as they are extensively used as biologically active compounds and are being considered an important alternative strategy for sustainable insect pest management in agriculture, because they are biodegradable and potentially suitable for the use in integrated management programs (Rattan, 2010). A brief research into the literature reveals many investigations applied into the biological activity of many plant components against a large number of pathogens and arthropods.…”

“…This last feature describes several important properties of the use of botanical extracts. The mixture of secondary metabolites may be deterrent to insects for a longer period than single compounds and, different physical properties may allow more deployment or longer persistence of defenses (Rattan, 2010). Thus, it is necessary that technical and economical studies evaluating if it is better to work by using a single molecule or botanical extracts are developed.…”

“…Natural products represent a rich source of biologically active compounds and are an example of molecular diversity, with recognized potential in pesticides discovery and development. They are in general structurally more complex, selective and biodegradable, environmentally compatible and less toxic to non-target organisms than synthetic pesticides (Alkofani et al, 1989;Duke et al, 2000;Rattan, 2010). Each molecule present in the secondary metabolism of plants may be explored individually either as a model to the development of new insecticides or as an isolated molecule which is an active compound of new insecticides.…”