MECHANISM OF MPP<SUP>+</SUP>-INDUCED CYTOTOXTCITY IN HUMAN NEURO-BLASTOMA SH-SY5Y

Reciprocal Response of Human Oral Epithelial Cells to Internalized Silica Nanoparticles

“…For cells exposed to the highest concentration of SiO 2 NPs, a 15% increase in ROS expression level was detected compared with the control group. Our observations also agree with previous studies documenting SiO 2 NPs treatment can enhance ROS expression level in a dose‐dependent manner . The diffused cytoplasmic staining of the cells suggested that ROS was produced in a non‐organelle specific manner (Figure B).…”

“…In this regard, examining the potential cytotoxic effects that may arise due to the interaction between SiO 2 NPs and biological systems thus become imperative . Recent studies have shown that SiO 2 NPs are capable of perturbing several fundamental cellular events such as cell viability, cell cycle progression, oxidative stress, inflammation, and key intracellular signaling cascades that are required for homeostatic regulation . The extent of these cytotoxic effects are highly dependent on particle size, surface chemistry, surface charge, morphology, porosity, and solubility .…”

Terminally differentiated SH-SY5Y cells provide a model system for studying neuroprotective effects of dopamine agonists

“…However, the concentrations of MPP + that are required to produce neurotoxicity in the undifferentiated state of this cell line are higher than those needed for mesencephalic cultures (Storch et al, 2000a). While it has been assumed that MPP + -induced cell death required the intracellular accumulation through DAT in the SH-SY5Y cell line (Spina et al, 1992;Song et al, 1997;Park et al, 1998;Kitamura et al, 1998), as it does in vivo, the relatively high resistance of these cells to this compound would suggest otherwise. The requirement to use relatively high concentrations of MPP + to produce neurotoxicity may be due to the low expression of the DAT and high expression of vesicular monoamine transporter (VMAT) in this cell line in the undifferentiated state.…”

Effect of Surface‐Modified Gold Nanorods on the Inflammatory Cytokine Response in Macrophage Cells

“…It was reported that excessive production of inflammatory mediators such as cytokines, chemokines, and growth factors can lead to acute or chronic inflammatory diseases . Recently, nanoparticles, such as silica and titanium dioxide have been shown to induce inflammatory cytokines . Unfortunately, there is little information on inflammatory cytokine induction by cellular uptake of GNRs.…”