Mechanism of Vasorelaxation Induced by Coptosapelta flavescens Stems Extract in Rat Thoraric Aorta

Ismail, Sjarif; Kosala, Khemasili; Fikriah, Ika; Magdaleni, Agustina Rahayu

doi:10.25026/jtpc.v4i2.146

Cited by 2 publications

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been known that vasodilation and vasoconstriction activities in blood vessels can be mediated by endotheliumdependent vascular smooth muscle cell (VSMC), by inducing endothelium to release endothelium-derived relaxing factor (EDRF) such as nitric oxide or prostacyclin or other EDRF, which is a vasodilator (Ismail et al, 2017), and also via endothelialindependent VSMC, by inhibiting the calcium channel which causes a reduction in Ca 2+ influx (Luna-Vázquez et al, 2013). To date, there are no data showing whether the vasodilatory activity of EBB extract depends on the endothelium or not.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of the vasodilatory activity of ethanol extracts of Eleutherine bulbosa bulbs and leaves

Fikriah¹,

Ismail²,

Kosala³

2021

J Appl Pharm Sci

View full text Add to dashboard Cite

The aim of this study was to examine and compare the vasodilatory activities of ethanol extracts of Eleutherine bulbosa bulbs (EBBs) and leaves (EBLs) on isolated aortas from Wistar rats, with and without endothelium. EBBs and leaves EBLs were washed with clean water and chopped and dried in a 60°C drying cabinet. Extraction was carried out by maceration using an ethanol solvent. The collected filtrate was concentrated using a vacuum evaporator, and the concentrated liquid was dried further in a 60°C oven. By carrying out relevant bioassays, the ethanol extracts of EBBs and leaves EBLs were evaluated using Wistar rat aortic rings, with and without endothelium in Krebs-Henseleit solution. Aortic rings were precontracted with phenylephrine solution, and after reaching the plateaued peak contraction, a single dose of the extract solution was administered, and the contractility was measured. The percentage of aortic dilation was presented as mean ± SD and statistically analyzed using the t-test, deemed significantly different if the p-value was < 0.05. The results showed that E. bulbosa leaf extracts induced vasodilation of aortic rings without endothelium, which was stronger than E. bulbosa bulb EBB extracts, indicating the vasodilatory activity through the endothelium-independent vascular smooth muscle.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of the vasodilatory activity of ethanol extracts of Eleutherine bulbosa bulbs and leaves

Fikriah¹,

Ismail²,

Kosala³

2021

J Appl Pharm Sci

View full text Add to dashboard Cite

show abstract

Effect of pH increasing of Wuluh star fruit (Averrhoa bilimbi L.) juice on vasodilatation activity

Ismail

Marliana

Kosala

2019

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

Mechanism of Vasorelaxation Induced by Coptosapelta flavescens Stems Extract in Rat Thoraric Aorta

Abstract: Coptosapelta flavescens Korth. is a liana plant from the Rubiaceae family. In East Kalimantan, it is also known as "Akar Tambolekar" or "Merung", it is called "akar" or

Cited by 2 publications

References 1 publication

In vitro evaluation of the vasodilatory activity of ethanol extracts of Eleutherine bulbosa bulbs and leaves

In vitro evaluation of the vasodilatory activity of ethanol extracts of Eleutherine bulbosa bulbs and leaves

Effect of pH increasing of Wuluh star fruit (Averrhoa bilimbi L.) juice on vasodilatation activity

Contact Info

Product

Resources

About