Mechanism Underlying Antitumor Effects of Sinomenine

Gao, Le-Nyu; Zhong, Bing; Wang, Yong

doi:10.1007/s11655-019-3151-2

Cited by 28 publications

(17 citation statements)

References 30 publications

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“…However, we found that there were not reveal any cell cycle disturbance by SH alone, but a significantly decreased iodine-131 induced G2/M arrest and increased S‑phase arrest by co-treatment SH and iodine-131, which was same as Zhang et al. found in Hela cells [11] . This special event may due to the elevated phosphorylation level of Chk1 S345, which is important for DNA damage‑mediated S‑phase checkpoint activation [43] .…”

Section: Discussionsupporting

confidence: 86%

“…Given that 1 mM was an already established concentration in previously published studies for a number of carcinoma cell lines [ 11 , 12 ], thus safe concentration of SH (0.8 mM) was selected for the subsequent experiments.…”

Section: Resultsmentioning

confidence: 99%

“…Within the past 30 years, the therapeutic efficacy and lower side effects of sinomenine in patients with rheumatoid arthritis (RA) have been confirmed in open clinical trials [ 9 , 10 ]. Moreover, Sinomenine hydrochloride (SH) has already been effectively used in rheumatoid arthritis during clinical practice [11] . Recently, several studies have demonstrated that SH not only has antineoplastic effects against various types of cancer, including lung cancer, gastric adenocarcinoma, breast cancer, but also it has been found that SH appears to be a prospective radiosensitizer in cervical cancer and esophageal squamous cell carcinoma therapy [12] , [13] , [14] , [15] , [16] .…”

Section: Introductionmentioning

confidence: 99%

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Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells

Zhao

Zhang

Liu

et al. 2021

Translational Oncology

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Highlights This is the first time to study and find out that sinomenine hydrochloride and iodine-131 synergic enhance the apoptosis and regulate DNA repair and cell cycle checkpoint on papillary thyroid carcinoma cells. This is the first time to study and find out that sinomenine hydrochloride increased the radiosensitivity of papillary thyroid carcinoma cells and normal thyroid cells. This is the first time to study and find out that sinomenine hydrochloride could be a potential therapeutic radiosensitizer in papillary thyroid carcinoma radiotherapy after total thyroidectomy .

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Section: Discussionsupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells

Zhao

Zhang

Liu

et al. 2021

Translational Oncology

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“…This study revealed that sinomenine can repress the VM formation and metastasis of breast cancer SP cells by modulating the miR-340-5p/ SIAH2 axis (Figure 5). As a class of isoquinoline alkaloids, sinomenine and its derivatives have many pharmacological activities, such as anticancer and immunomodulatory activities [8][9][10]. Our previous study indicated that low dose of sinomenine has little cytotoxicity on breast cancer cells and their SP cells [9, 11], but effectively inhibits the invasion and migration of breast cancer cells [9], as well as suppresses the invasive ability of breast cancer SP cells [11].…”

Section: Discussionmentioning

confidence: 99%

Sinomenine Inhibits Vasculogenic Mimicry and Migration of Breast Cancer Side Population Cells via Regulating miR-340-5p/SIAH2 Axis

Song

Tang

et al. 2022

BioMed Research International

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Hypoxia and its induced vasculogenic mimicry (VM) formation, which both closely related with stem-like side population (SP) cells, are the main culprits leading to tumor invasion and metastasis. Sinomenine exhibits excellent anticancer activity in breast cancer, but whether and how it affects hypoxia-triggered VM formation in breast cancer SP cells remains unclear. In this study, breast cancer SP cells were sorted from MDA-MB-231 cells and cultured with sinomenine under hypoxic conditions. Sinomenine obviously repressed the migration and VM formation of breast cancer SP cells. Through downregulating SIAH2 and HIF-1α, sinomenine can inhibit epithelial-mesenchymal transition process of breast cancer SP cells. SIAH2 was identified as a target of miR-340-5p and was downregulated by it, and sinomenine can upregulate miR-340-5p. Hypoxia-induced downregulation of miR-340-5p and activation of SIAH2/HIF-1α pathway can be both counteracted by the sinomenine. Moreover, miR-340-5p inhibition and SIAH2 overexpression can partly counteract the anticancer effects of sinomenine. Taken together, sinomenine inhibits hypoxia-caused VM formation and metastasis of breast cancer SP cells by regulating the miR-340-5p/SIAH2 axis.

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“…SIN possesses anti-inflammatory activity and has been used to treat rheumatoid diseases in humans 9 , 10 , 11 . It was also reported that SIN has antitumor effects 12 , such as lung cancer 13 , gastric cancer 14 , prostate cancer 15 , and breast cancer 16 . However, SIN has some disadvantages, such as adverse gastrointestinal reactions, short biological half-life, and unstable physicochemical properties 17 .…”

Section: Introductionmentioning

confidence: 96%

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

Zheng

Wan

et al. 2021

Acta Pharmaceutica Sinica B

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Glioblastoma multiforme (GBM) in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it. Studies of sinomenine, an alkaloid from the Chinese medicinal plant, Sinomenium acutum , showed that it had inhibitory effects on several kinds of cancer. Here, we synthesized a sinomenine derivative, sino-wcj-33 (SW33), tested it for antitumor activity on GBM and explored the underlying mechanism. SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells. It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis. Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body. SW33 also induced autophagy through the PI3K/AKT/mTOR and AMPK/mTOR pathways. Thus, SW33 appears to be a promising drug for treating GBM effectively and safely.

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Mechanism Underlying Antitumor Effects of Sinomenine

Cited by 28 publications

References 30 publications

Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells

Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells

Sinomenine Inhibits Vasculogenic Mimicry and Migration of Breast Cancer Side Population Cells via Regulating miR-340-5p/SIAH2 Axis

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

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