Mechanisms and biomarker candidates in pterygium development

Wanzeler, Ana Cláudia Viana; Barbosa, Ítalo Antunes França; Duarte, Bruna Aparecida Rodrigues; Borges, Daniel; Barbosa, Eduardo Buzolin; Kamiji, Danielle; Huarachi, Delma Regina Gomes; Melo, Mônica Barbosa de; Alves, Mônica

doi:10.5935/0004-2749.20190103

Cited by 41 publications

(36 citation statements)

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“…Pterygium is characterized by in ammatory in ltrates, brosis, proliferation, angiogenesis and extracellular matrix breakdown and its pathogenesis is mainly associated with long-term exposure to ultraviolet radiation [1]. Moreover, apoptotic and oncogenic proteins, DNA methylation, lymphangiogenesis, viral infection, extracellular matrix modulators, in ammatory mediators, loss of heterozygosity, microsatellite instability, alterations in cholesterol metabolism and epithelialmesenchymal cell transition have been identi ed as other causes [2].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…UV irradiation relays its toxic impacts either directly by UV phototoxicity or indirectly by formation of primary molecules causing oxidative damage (aka reactive oxygen species or ROS). Imbalance between growth factors and cytokines, changes in tear lm, viral infections, genetic mutations, immunologic disturbances and chronic in ammation are also believed to be the important factors [2]. Pterygium is usually observed to be asymptomatic in the beginning, however, if it grows over the pupillary axis or induces astigmatism causing chronic ocular irritation, cosmetic imparity or visual disturbance, surgical intervention becomes inevitable.…”

Section: Introductionmentioning

confidence: 99%

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Dynamic Thiol Disulphide Homeostasis in Patients with Surfer’s Eye: A Case-Control Study

Akcam

Erel

2021

Preprint

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Purpose The role of oxidative stress in the pathogenesis of pterygium is still unclear. However, abnormal thiol disulfide homeostasis levels are involved in the pathogenesis of various systemic or ocular diseases. We aim to analyze dynamic thiol disulphide homeostasis in patients suffering from conjunctival pterygium using a contemporary technique. Methods Thirty-eight subjects suffering from pterygium and 35 age-gender matched healthy volunteers were recruited for study. For each case, total thiol, disulfide and native thiol levels in blood were obtained. Additionally, ratio of disulfide over total thiol, native thiol over total thiol and disulfide over native thiol were computed. Results The level of median native thiol was lower in pterygium group (318.2 µmol /L vs 333.4 µmol /L) and median disulfide was slightly higher in pterygium group (24.3 µmol /L vs 22.8 µmol /L) compared to control group. Both disulfide over total thiol and disulfide over native thiol ratios were higher in pterygium group, ratio of native thiol over total thiol was found to be higher in control group. Nevertheless, none of those differences were statistically significant at 95% confidence level. Notably, correlation test pointed to a negative correlation both between pterygium grade and native thiol and between total thiol and pterygium grade in pterygium group (P = 0.03 and 0.02 respectively). Conclusion A negative correlation hinting that slightly weakened dynamic thiol disulphide homeostasis in subjects with pterygium, a local ocular disease. Further studies with larger sample sizes may shed light on this potential relationship and justify systemic antioxidant therapies in these cases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dynamic Thiol Disulphide Homeostasis in Patients with Surfer’s Eye: A Case-Control Study

Akcam

Erel

2021

Preprint

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“…Excessive exposure to UVB (especially by way of OS) is one of the most important causes of pterygium [35]. UVB radiation may cause toxic light damage to DNA directly or by increasing ROS, which causes DNA damage [53]. In patients with pterygium, the serum total oxidant status (TOS), total antioxidant status (TAS), and nitric oxide (NO) and MDA content were significantly increased, and the antioxidant enzyme (SOD, CAT, and GPX) content was decreased [54,55], indicating an increase in nonenzyme antioxidant activity.…”

Section: Fuchs' Endothelial Corneal Dystrophy (Fecd)mentioning

confidence: 99%

Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update

Wang

Zhao

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) is a regulator of many processes of life, and it plays an important role in antioxidant, anti-inflammatory, and antifibrotic responses and in cancer. This review is focused on the potential mechanism of Nrf2 in the occurrence and development of ocular diseases. Also, several Nrf2 inducers, including noncoding RNAs and exogenous compounds, which control the expression of Nrf2 through different pathways, are discussed in ocular disease models and ocular cells, protecting them from dysfunctional changes. Therefore, Nrf2 might be a potential target of protecting ocular cells from various stresses and preventing ocular diseases.

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“…Verschiedene Studien haben bereits mögliche molekulare Mechanismen der Pterygiumentstehung untersucht [1][2][3][4][5][6]. Diese molekularen Mechanismen umfassen, teilweise durch UV-Strahlung oder virale Infektionen initiiert, unter anderem oxidativen Stress, Modulation der Extrazellularmatrix, Veränderung der Expression von apoptotischen Proteinen und Tumorsuppressorgenen, Verlust der Heterozygose, DNA-Methylierung, erhöhte Expression von Entzündungsmediatoren, gesteigerte (Lymph-)Angiogenese und Veränderungen des Cholesterinstoffwechsels [1][2][3][4][5].…”

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