Mechanisms and Surface Chemical Prediction of Imipramine ‐Induced Hemolysis Suppressed by Modified Cyclodextrins

Funasaki, Noriaki; Okuda, Toshikatsu; Neya, Saburo

doi:10.1002/jps.1059

Cited by 12 publications

(4 citation statements)

References 27 publications

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“…The areas found in this work are in agreement with the few data reported in literature. For examples, the areas found for RAME-β-CD (12.6) and HP-β-CD (4.2) were very close to those reported for DIME-β-CD (14.0) and HP-β-CD (4.8) (RAME-β-CD (12.6): 257 Å 2 ; HP-β-CD (4.2): 306 Å 2 ; DIME-β-CD (14.0): 216 Å 2 and HP-β-CD (4.8): 355 Å 2 ) [40]. Much more interesting is the fact that all the calculated areas suggest that the CDs are adsorbed to the interface with the axis of the cavity perpendicular to the interface [41].…”

Section: Resultssupporting

confidence: 87%

Biphasic aqueous organometallic catalysis promoted by cyclodextrins: Can surface tension measurements explain the efficiency of chemically modified cyclodextrins?

Leclercq

Bricout

Tilloy

et al. 2007

Journal of Colloid and Interface Science

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Section: Resultssupporting

confidence: 87%

Biphasic aqueous organometallic catalysis promoted by cyclodextrins: Can surface tension measurements explain the efficiency of chemically modified cyclodextrins?

Leclercq

Bricout

Tilloy

et al. 2007

Journal of Colloid and Interface Science

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“…However, in vitro, hemolytic activity of CDs has been reported, with the potency being reported as DM-β-CD>HP-β-CD. 23) Binding of guest to HP-β-CD is very similar to β-CD. 21) Furthermore, HP-β-CD is widely used as a pharmaceutical solubilization agent, and is known to have high safety.…”

Section: Resultsmentioning

confidence: 97%

Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate

et al. 2016

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The stomatitis caused by anticancer agents and radiation therapy deteriorates patient QOL, potentially causing eating disorders as a result of pain. Although gargling and ointments can be used in the treatment of stomatitis, patients must spit out mouthwash after use, while ointment application requires a finger to be inserted into the oral cavity. In contrast, sprays eliminate these potential compliance problems. Therefore, we developed a stomatitis spray that remains on the oral mucosa. It has been reported that irsogladine maleate (IM) is effective against stomatitis via oral administration. IM is water insoluble; thus, it was dissolved with various cyclodextrins (CDs). Furthermore, we examined combination with gum ghatti (GG), a mucoadhesive polymer. The interaction between mucin and GG was examined by Quartz Crystal Microbalance with Dissipation monitoring. We found that GG exhibited mucoadhesion. Furthermore, we examined the healing effects of IM on stomatitis in a stomatitis model hamster. We found that stomatitis healed after direct application of IM. However, the model used in this experiment is not based on stomatitis caused by anticancer agents. Further study is therefore necessary.

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“…The cationic properties of VFX [48] and IPM [49] in an aqueous solution posed a challenge in using a cation-exchange column for removing interfering cations. Therefore, it is recommended that future scientific studies utilize separation techniques, as described in reference [50], to accurately measure the concentration of the two drugs in water samples.…”

Section: Interference Studymentioning

confidence: 99%

FeS₂ nanosheets–luminol–O₂ chemiluminescence method for determination of venlafaxine hydrochloride, imipramine hydrochloride, and cefazolin sodium

Iranifam,

Royan,

Golshani

et al. 2024

Luminescence

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This study introduces a novel chemiluminescence (CL) approach utilizing FeS2 nanosheets (NSs) catalyzed luminol–O2 CL reaction for the measurement of three pharmaceuticals, namely venlafaxine hydrochloride (VFX), imipramine hydrochloride (IPM), and cefazolin sodium (CEF). The CL method involved the phenomenon of quenching induced by the pharmaceuticals in the CL reaction. To achieve the most quenching efficacy of the pharmaceuticals in the CL reaction, the concentrations of reactants comprising luminol, NaOH, and FeS2 NSs were optimized accordingly. The calibration curves demonstrated exceptional linearity within the concentration range spanning from 4.00 × 10−7 to 1.00 × 10−3 mol L−1, 1.00 × 10−7 to 1.00 × 10−4 mol L−1, and 4.00 × 10−6 to 2.00 × 10−4 mol L−1 with detection limits (3σ) of 3.54 × 10−7, 1.08 × 10−8, and 2.63 × 10−6 mol L−1 for VFX, IPM, and CEF, respectively. This study synthesized FeS2 NSs using a facile hydrothermal approach, and then the synthesized FeS2 NSs were subjected to a comprehensive characterization using a range of spectroscopic methods. The proposed CL method was effective in measuring the aforementioned pharmaceuticals in pharmaceutical formulations as well as different water samples. The mechanism of the CL system has been elucidated.

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Mechanisms and Surface Chemical Prediction of Imipramine ‐Induced Hemolysis Suppressed by Modified Cyclodextrins

Cited by 12 publications

References 27 publications

Biphasic aqueous organometallic catalysis promoted by cyclodextrins: Can surface tension measurements explain the efficiency of chemically modified cyclodextrins?

Biphasic aqueous organometallic catalysis promoted by cyclodextrins: Can surface tension measurements explain the efficiency of chemically modified cyclodextrins?

Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate

FeS₂ nanosheets–luminol–O₂ chemiluminescence method for determination of venlafaxine hydrochloride, imipramine hydrochloride, and cefazolin sodium

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Mechanisms and Surface Chemical Prediction of Imipramine ‐Induced Hemolysis Suppressed by Modified Cyclodextrins

Cited by 12 publications

References 27 publications

Biphasic aqueous organometallic catalysis promoted by cyclodextrins: Can surface tension measurements explain the efficiency of chemically modified cyclodextrins?

Biphasic aqueous organometallic catalysis promoted by cyclodextrins: Can surface tension measurements explain the efficiency of chemically modified cyclodextrins?

Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate

FeS2 nanosheets–luminol–O2 chemiluminescence method for determination of venlafaxine hydrochloride, imipramine hydrochloride, and cefazolin sodium

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Product

Resources

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FeS₂ nanosheets–luminol–O₂ chemiluminescence method for determination of venlafaxine hydrochloride, imipramine hydrochloride, and cefazolin sodium