Mechanisms of estrogen receptor-α upregulation in breast cancers

Miyoshi, Yasuo; Murase, K; Saito, Masaru; Imamura, Michiko; Oh, Koushi

doi:10.1007/s00795-010-0514-3

Cited by 36 publications

(29 citation statements)

References 22 publications

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“…These results suggest that Tamoxifen up-regulates ERa expression by increasing promoter activity of the ERa gene (Ers1) at the transcriptional level [12].…”

Section: Discussionmentioning

confidence: 83%

Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice

Hesselbarth

Pettinelli

Gericke

et al. 2015

Biochemical and Biophysical Research Communications

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“…These results suggest that Tamoxifen up-regulates ERa expression by increasing promoter activity of the ERa gene (Ers1) at the transcriptional level [12].…”

Section: Discussionmentioning

confidence: 83%

Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice

Hesselbarth

Pettinelli

Gericke

et al. 2015

Biochemical and Biophysical Research Communications

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“…ERs consist of two isoforms, ERα and ERβ, which have been identified to be expressed in multiple tissues, including the mammary gland (19). ERα is the primary type of ER in breast tissues, and is encoded by the ESR1 gene (20). High expression levels of ERα correlate with increased mRNA levels of ESR1 (19).…”

Section: A B C Dmentioning

confidence: 99%

S100A8/A9 is associated with estrogen receptor loss in breast cancer

Bao

Wang

2016

Oncology Letters

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Abstract. S100A8 and S100A9 are calcium-binding proteins that are secreted primarily by granulocytes and monocytes, and are upregulated during the inflammatory response. S100A8 and S100A9 have been identified to be expressed by epithelial cells involved in malignancy. In the present study, the transcriptional levels of S100A8 and S100A9 were investigated in various subtypes of breast cancer (BC), and the correlation with estrogen receptor 1 (ESR1) and GATA binding protein 3 (GATA3) gene expression was evaluated using microarray datasets. The expression of S100A8 and S100A9 in BC cells was assessed by reverse transcription-polymerase chain reaction (RT-PCR). The regulation of ESR1 and GATA3 by administration of recombinant S100A8/A9 was examined in the BC MCF-7 cell line using quantitative (q)PCR. The association between S100A8 and S100A9 and overall survival (OS) was investigated in GeneChip ® data of BC. The expression levels of S100A8 and S100A9 were higher in human epidermal growth factor receptor 2 (Her2)-amplified and basal-like BC. The messenger (m)RNA levels of S100A8 and S100A9 were inversely correlated with ESR1 and GATA3 expression. S100A8/A9 induced a 10-fold decrease in the mRNA levels of ESR1 in MCF-7 cells. Poor OS was associated with high expression levels of S100A9, but not with high expression levels of S100A8 in BC. In conclusion, strong expression and secretion of S100A8/A9 may be associated with the loss of estrogen receptor in BC, and may be involved in the poor prognosis of Her2 + /basal-like subtypes of BC.

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“…Studies using ER knockout animal models have shown that ER α is the predominant mediator of mitogenic effects of oestrogen in the breast [69] , and it tends to be ER α , which is expressed at highest levels in ER + breast cancers [70] . However, the majority of ER α -positive breast tumours also contain ER β , and in its role as a putative tumour suppressor, ER β can act to ameliorate the proliferative effects of ER α such that tumours with increased levels of ER β compared to ER α can have a more favourable prognosis [71,72] .…”

Section: Differential Effects Through Alteration To Relative Levels Omentioning

confidence: 99%

Molecular mechanisms of oestrogen action on growth of human breast cancer cells in culture

Darbre

2012

Hormone Molecular Biology and Clinical Investigation

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Growth responses to oestrogen can be reproducibly obtained using a selection of oestrogen-receptor-containing human breast cancer cell lines, and molecular mechanisms have been shown to include modulation to growth factor/receptor/signalling pathways, cell-cycle proteins, apoptosis, differentiation, adhesion, motility and migration. Considerable progress has been made in understanding the molecular basis of oestrogen action on gene expression through the ligand-activated transcription factors human oestrogen receptor α (ERα) and ERβ and the resulting effects on global gene expression patterns, but the full profile of coordination of the alterations, which brings about changes in cell growth through genomic and non-genomic mechanisms remain to be fully elucidated. Oestrogen regulation of cell growth involves a complex cross-talk between oestrogen receptor and growth factor signalling pathways such that inhibition of one pathway may lead to stimulation of another, which may explain the remarkable ability of human breast cancer cells to escape from any mode of imposed growth inhibition be it oestrogen deprivation or administration of antioestrogen. Although studies on cell growth have focused to date on the effects of physiological oestrogens, many hundreds of environmental chemicals with oestrogenic properties have now been measured in the human breast. Whether or not the weight of evidence eventually establishes any causal link of complex mixtures of environmental oestrogenic chemicals with breast cancer, the presence of so many oestrogenic chemicals in the breast must influence resulting oestrogenic responses, and the impact of this additional oestrogenic burden needs to be taken into account in future studies on growth regulation of human breast cancer cells.

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Mechanisms of estrogen receptor-α upregulation in breast cancers

Cited by 36 publications

References 22 publications

Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice

Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice

S100A8/A9 is associated with estrogen receptor loss in breast cancer

Molecular mechanisms of oestrogen action on growth of human breast cancer cells in culture

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