Mechanisms of Nonimmunological Histamine and Tryptase Release from Human Cutaneous Mast Cells

Veien, Mette; Szlam, Fania; Holden, Jeannine T.; Yamaguchi, Kensei; Denson, Donald D.; Levy, Jerrold H.

doi:10.1097/00000542-200004000-00026

Cited by 96 publications

(46 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This suggests that we are investigating potentially complementary mechanisms (4). That is in accordance with mechanisms proposed in reactions to muscle relaxants, which are not always driven by an immunologic process (e.g., IgE against ammonium group).…”

Section: Discussionsupporting

confidence: 79%

“…That is in accordance with mechanisms proposed in reactions to muscle relaxants, which are not always driven by an immunologic process (e.g., IgE against ammonium group). Some anaphylactoid reactions are due to nonimmunologic stimulation and lead to histamine and tryptase release as well (4). Thus, it is consistent to find a negative specific IgE along with a positive CD63 test since our protocol investigates the common final feature of both mechanisms, which is basophil degranulation.…”

Section: Discussionsupporting

confidence: 65%

“…These drugs induce two types of reaction. One is driven by an immunologic mechanism and is IgE-dependent (specific IgE antibodies against ammonium group) (3), while the second one, particularly described with atracurium (4), is due to a nonimmunologic stimulation of basophils and mast cells. Both mechanisms lead to a common feature that is the release of histamine and tryptase from these cells (4).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Monitoring of Basophil Activation Using CD63 and CCR3 in Allergy to Muscle Relaxant Drugs

Monneret

Benoit

Debard

et al. 2002

Clinical Immunology

114

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Monitoring of Basophil Activation Using CD63 and CCR3 in Allergy to Muscle Relaxant Drugs

Monneret

Benoit

Debard

et al. 2002

Clinical Immunology

114

View full text Add to dashboard Cite

“…This could be the result of direct action of vancomycin on PLC and PLA2 or by unknown receptor stimulation mechanism (Veien et al, 2000).…”

Section: Molecular Events and Clinical Manifestations Of Anaphylactoimentioning

confidence: 99%

Vancomycin as a risk factor for anaphylactoid reaction (Red Man Syndrome): Literature review

Reyes¹

2013

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Vancomycin is the antibiotic of first choice for the treatment of methicillin resistant Staphylococcus aureus (MRSA) infection. Its use is associated with adverse effects in children with a frequency of 5 -14% and in adults with 1.6 -35%. Of these adverse effects to vancomycin, two kinds have been described. The first is anaphylactic immunologic or immediate hypersensitivity mediated by immunoglobulin type E (IgE). The second is IgE independent anaphylactoid reaction, also referred to as nonallergic drug hypersensitivities or pseudoallergic reactions, known as red man syndrome (RMS). The signs and symptoms of anaphylactoid reaction principally occur in the first dose of vancomycin and could be accompanied by hypotension and cardiac arrest. The severity of the reaction is proportional to the dose administered, infusion velocity, and liberation of histamine in blood.

show abstract

“…Measurement of histamine levels in the skin is an important clinical parameter in various allergy diseases such as anaphylaxis [1,2] , atopic dermatitis [3,4] , pruritus [5,6] , allergic skin inflammation [7,8] , mastocytosis [9] , hives [10,11] and psoriatic skin [12] , as well as in preclinical experimental allergy research [13][14][15][16][17][18] .…”

Section: Determination Of Histamine In Microdialysismentioning

confidence: 99%

Determination of Histamine in Microdialysis Samples from Guinea Pig Skin by High-Performance Liquid Chromatography with Fluorescence Detection

Yoshitake

Ijiri

Yoshitake

et al. 2011

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Aim: To develop a sensitive and selective liquid-chromatographic method for the determination of histamine in microdialysis samples from guinea pig skin following allergenic provocation. Methods: The novel fluorescence derivatization method is based on an intramolecular excimer-forming reaction between 2 amino moieties of histamine and 2 molecules of 4-(1-pyrene)butanoyl chloride (PBC) yielding the corresponding dipyrene-labeled derivative. Results: The PBC derivative of histamine was separated within 20 min, and the detection limit (signal-to-noise ratio = 3) of histamine was 0.6 fmol/20 µl volume injected. The basal extracellular levels of histamine in guinea pig skin microdialysates were 20.6 ± 1.7 fmol/10 µl. Subcutaneous administration of histamine liberator compound 48/80 (3 mg/kg) increased the extracellular histamine levels in the skin dialysates by about 860%, whereas ovalbumin challenge (2 mg/kg i.v.) in the sensitized guinea pigs increased the extracellular histamine levels by about 3,030%. Conclusion: The novel technique for histamine determination in microdialysis samples from the guinea pig skin may be utilized in preclinical research of antihistaminergic drugs and evaluation of allergenic properties of various dermal preparations such as transdermal drug delivery systems.

show abstract

Mechanisms of Nonimmunological Histamine and Tryptase Release from Human Cutaneous Mast Cells

Abstract: Tryptase is not a specific marker of mast cell activation (ie., anaphylaxis), and signaling mechanisms for mast cell activation involve activation of phospholipase C and phospholipase A2 pathways that are also involved in other cellular activation mechanisms.

Cited by 96 publications

References 1 publication

Monitoring of Basophil Activation Using CD63 and CCR3 in Allergy to Muscle Relaxant Drugs

Monitoring of Basophil Activation Using CD63 and CCR3 in Allergy to Muscle Relaxant Drugs

Vancomycin as a risk factor for anaphylactoid reaction (Red Man Syndrome): Literature review

Determination of Histamine in Microdialysis Samples from Guinea Pig Skin by High-Performance Liquid Chromatography with Fluorescence Detection

Contact Info

Product

Resources

About