Mechanisms of skin moisturization with hyperharmonized hydroxyl modified fullerene substance

Miljković, Suzana; Jeftić, Branislava; Stanković, Ivana; Stojiljkovic, Nikola; Koruga, Djuro

doi:10.1111/jocd.13965

Cited by 9 publications

(12 citation statements)

References 19 publications

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“…On the other hand, there is wide range of fullerene-based skincare products that have been clinically verified and used by people for several years, implying that fullerenes and related materials are quite safe for topical application [ 81 ]. Compared to the control groups, cosmetic products containing 3HFWC nanosubstance demonstrated positive effects, including faster collagen regeneration and prompt skin reaction to the negative environmental influences [ 13 , 82 ]. The in vitro studies with melanoma cells recently revealed that 3HFWC nanosubstance treatments induced cell reprogramming, suggesting their use as a nonaggressive strategy for tumor growth suppression [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Physiological Response, Oxidative Stress Assessment and Aquaporin Genes Expression of Cherry Tomato (Solanum lycopersicum L.) Exposed to Hyper-Harmonized Fullerene Water Complex

Subotić

Jevremović

Milošević

et al. 2022

Plants

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The rapid production and numerous applications of nanomaterials warrant the necessity and importance of examining nanoparticles in terms to their environmental and biological effects and implications. In this study, the effects of a water-soluble hyper-harmonized hydroxyl-modified fullerene (3HFWC) on cherry tomato seed germination, seedlings growth, physiological response and fruiting was evaluated. Changes in the photosynthetic pigments content, oxidative stress assessment, and aquaporin genes expression in cherry tomato plants were studied after during short- and long-term continuous exposure to 3HFWC nanosubstance (200 mg/L). Increased levels of photosynthetic pigments in leaves, lycopene in fruits, decreased levels of hydrogen peroxide content, activation of cellular antioxidant enzymes such as superoxide dismutase, catalase and peroxidase and increased aquaporin gene expression (PIP1;3, PIP1;5 and PIP2;4) were observed in 3HFWC nanosubstance-exposed plants in comparison to control, untreated cherry tomato plants. The 3HFWC nanosubstance showed positive effects on cherry tomato seed germination, plantlet growth and lycopene content in fruits and may be considered as a promising nanofertilizer.

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Section: Discussionmentioning

confidence: 99%

Physiological Response, Oxidative Stress Assessment and Aquaporin Genes Expression of Cherry Tomato (Solanum lycopersicum L.) Exposed to Hyper-Harmonized Fullerene Water Complex

Subotić

Jevremović

Milošević

et al. 2022

Plants

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“…Fullerenes (or buckyballs) are spherical structures with many carbon atoms [ 260 ]. They can deliver biopeptides in cosmetics (e.g., anti-wrinkle, anti-acne, lightening toner, pore reduction, and moisturizing creams) and sunscreen [ 261 , 262 ].…”

Section: Peptide Delivery Systemsmentioning

confidence: 99%

Food Peptides for the Nutricosmetic Industry

Dini

Mancusi

2023

Antioxidants

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In recent years, numerous reports have described bioactive peptides (biopeptides)/hydrolysates produced from various food sources. Biopeptides are considered interesting for industrial application since they show numerous functional properties (e.g., anti-aging, antioxidant, anti-inflammatory, and antimicrobial properties) and technological properties (e.g., solubility, emulsifying, and foaming). Moreover, they have fewer side effects than synthetic drugs. Nevertheless, some challenges must be overcome before their administration via the oral route. The gastric, pancreatic, and small intestinal enzymes and acidic stomach conditions can affect their bioavailability and the levels that can reach the site of action. Some delivery systems have been studied to avoid these problems (e.g., microemulsions, liposomes, solid lipid particles). This paper summarizes the results of studies conducted on biopeptides isolated from plants, marine organisms, animals, and biowaste by-products, discusses their potential application in the nutricosmetic industry, and considers potential delivery systems that could maintain their bioactivity. Our results show that food peptides are environmentally sustainable products that can be used as antioxidant, antimicrobial, anti-aging, and anti-inflammatory agents in nutricosmetic formulations. Biopeptide production from biowaste requires expertise in analytical procedures and good manufacturing practice. It is hoped that new analytical procedures can be developed to simplify large-scale production and that the authorities adopt and regulate use of appropriate testing standards to guarantee the population’s safety.

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“…So that it has been widely studied in cosmetic materials, biomedicine, and other aspects. In the field of skin care, fullerenes have the functions of antioxygen, 8 anti‐wrinkle, 9,10 whitening, 11 protective barrier, anti‐inflammatory, acne removal, rad fading, 12 shrinking pores, and so on. In addition, the scientists have found that fullerenes have excellent therapeutic effects on parkinson's disease, 13,14 enteritis, 15 diabetes, pulmonary fibrosis, 16 and reduced side effects in the process of radiotherapy and chemotherapy significantly 17 …”

Section: Introductionmentioning

confidence: 99%

A novel fullerene composite material for directional oil control and antioxidant

Lu,

Xu,

Cheng

et al. 2024

J of Cosmetic Dermatology

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BackgroundThere are very few cosmetic ingredients that can target oil control and extend the wear time. Fullerenes have been reported to have excellent antioxidant capacity and a variety of biological activities, such as quenching free radicals, inhibiting lipid peroxidation, and promoting lipid flocculation.ObjectiveThe purpose of applying foundation makeup on the face is to make the skin color even, but the secretion and oxidation of skin oil will make the makeup mottled and dull. In order to solve this problem, a fullerene composite material that can directionally absorb oil and resist oil oxidation has been developed.MethodsFullerenes and hydroxyapatite composite was prepared by high pressure homogenization under alkaline condition. The indicated morphology and structure were characterized by SEM, UV–Vis, Raman, and XRD. The oil absorption capacity was determined by adding the C60‐hydroxyapatite composite to a mixed solution of hexane and oil, shaking for 1 h, filtering, analyzed by GC–MS, and calculating the oil absorption by external standard method. Artificial sebum was prepared by adding different mass of water and oleic acid to screen the optimum ratio. C60‐hydroxyapatite mixture and C60‐hydroxyapatite composite were added to the artificial sebum to test the oil‐absorbing capacity of the materials. The hydroxyl radical scavenging ability of C60‐hydroxyapatite composite containing different fullerene contents was measured by X‐band ESR spectroscopy, and the long‐term radical scavenging ability of the composites was tested in comparison with VC. Antioxidant experiment is adding C60‐hydroxyapatite composite material, and hydroxyapatite to oleic acid, then the UV light irradiation is aimed to accelerate the oxidation of oleic acid. Oleic acid act as a control group, and make the detection of oleic acid peroxide value after 7 days. The safety of the materials was tested by using culture media to soak the C60‐hydroxyapatite composite for 24 h and then used to culture cells.ResultsThe characterization of SEM, UV–Vis, Raman, and XRD showed that fullerene clusters were dispersed on the surface of hydroxyapatite stably, and they formed a stable composite. The adsorption rates of C60‐hydroxyapatite composites for oleic acid, phenyl trimethicone, caprylic capric glyceride, isooctyl palmitate, mineral oil, olive oil, and dimethicone were 60.5%, 9.3%, 9.15%, 5.24%, 2.94%, 1.01%, and 0%, respectively. The flocculation amount of artificial sebum was 5.9 g per gram of C60‐hydroxyapatite mixture and 24.2 g per gram of C60‐hydroxyapatite composite. C60‐hydroxyapatite composites have excellent quenching ability for hydroxyl radicals. When the fullerene content is 1, 2, 3, and 4 mg/kg, the quenching rates are 25.02%, 39.57%, 49.75%, and 62.24%, respectively. The quenching effect was enhanced with the increase of fullerene content, and it had strong long‐term antioxidant properties. It can also be proved that C60‐hydroxyapatite composites have strong antioxidant capacity through antioxidant experiments. The peroxide value of oleic acid on Day 0 was 2.8, and after 7 days of UV irradiation, the peroxide values of blank control, hydroxyapatite group, C60‐hydroxyapatite composite containing 0.5% and 1% fullerenes four groups of materials were 8.02 meq O2/kg, 7.98 meq O2/kg, 7.11 meq O2/kg, and 6.87 meq O2/kg, respectively. The cell activity was 20.94% and 99.2% after the cells were cultured for 24 h using C60‐hydroxyapatite composite and hydroxyapatite extracts, respectively, and the addition of fullerene was able to significantly increase the cell activity.ConclusionFullerene hydroxyapatite complex has excellent directional oil absorption characteristics, which can effectively remove free radicals and reduce skin oil oxidation.

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Mechanisms of skin moisturization with hyperharmonized hydroxyl modified fullerene substance

Cited by 9 publications

References 19 publications

Physiological Response, Oxidative Stress Assessment and Aquaporin Genes Expression of Cherry Tomato (Solanum lycopersicum L.) Exposed to Hyper-Harmonized Fullerene Water Complex

Physiological Response, Oxidative Stress Assessment and Aquaporin Genes Expression of Cherry Tomato (Solanum lycopersicum L.) Exposed to Hyper-Harmonized Fullerene Water Complex

Food Peptides for the Nutricosmetic Industry

A novel fullerene composite material for directional oil control and antioxidant

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