Mechanisms of thrombosis and research progress on targeted antithrombotic drugs

Zhang, Lei; Li, Zhen; Ye, Xianren; Chen, Zhuo; Chen, Zhe‐Sheng

doi:10.1016/j.drudis.2021.04.023

Cited by 27 publications

(20 citation statements)

References 235 publications

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“…Platelet aggregation and plasma coagulation are 2 major events resulting in thrombosis. 10 Their dysregulation ultimately leads to the excessive or unregulated formation of thrombi. An extract of S. commixta attenuated platelet aggregation, but exhibited minimal effects on plasma coagulation.…”

Section: Discussionmentioning

confidence: 99%

Antithrombotic Effect of Sorbus commixta in an Arterial Thrombosis Mouse Model

Kim

Park

Kim

et al. 2022

Natural Product Communications

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Sorbus commixta Hedlund ( S. commixta) is known to possess cardiovascular protective activity. However, its effect on thrombosis has not been reported, although thrombosis plays a primary role in diverse circulatory diseases. Thus, this study was performed to assess the antithrombotic activity of dried S. commixta fruit extract. Mice were fed with a diet containing 8.3% extract for 4 weeks, which corresponded to the consumption of approximately 1000 mg extract/kg/day. The antithrombotic effect was tested in a FeCl3-induced arterial thrombosis model. Additionally, the effects on platelet aggregation and plasma coagulation were examined in vitro using washed platelets (WP) and isolated blood plasma, respectively. Thrombotic vascular occlusion time was significantly prolonged by the 4-week administration of the extract. Treatment of WP with the extract resulted in a decrease in thrombin-induced aggregation, which was concentration-dependent over 10 to 100 μg/mL and was not attributed to the direct inhibition of thrombin. The extract did not affect blood plasma coagulation, which was assessed by measuring prothrombin time and activated partial thromboplastin time. S. commixta is capable of preventing arterial thrombosis and such an effect may be attributed to the inhibition of platelet aggregation.

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Section: Discussionmentioning

confidence: 99%

Antithrombotic Effect of Sorbus commixta in an Arterial Thrombosis Mouse Model

Kim

Park

Kim

et al. 2022

Natural Product Communications

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“…Muitos estudos mostraram o elevado potencial antioxidante dos polifenóis e seu uso na conservação de alimentos devido à inibição da oxidação lipídica e efeito antibacteriano (Messina et al, 2019;Peixoto et al, 2018). Sousa e colaboradores (2017) reportaram a importância do trans-resveratrol (forma ativa do resveratrol) presente nas cascas das uvas vermelhas, cuja ação-hipertensiva e redução da morbilidade causada pela doença coronária está bem documentada (Akaberi e Hosseinzadeh, 2016;Salehi et al, 2018;Wong et al, 2016;Zhang et al, 2021).…”

Section: Compostos Químicos No Bagaço De Uvaunclassified

“…Nesse sentido, pesquisas recentes têm sugerido o desenvolvimento de alternativas farmacológicas, como antitrombóticos direcionados e terapias adicionais incluindo o uso de fitoterápicos derivados de alimentos (CHENG et al, 2019;ZHANG et al, 2021). Em particular, os compostos bioativos, sobretudo polifenóis, têm apresentado potencial ação farmacológica na modulação da função plaquetária (NIGNPENSE et al, 2020).…”

Section: Introductionunclassified

Estado Nutricional E Aptidão Física De Crianças E Adolescentes: Influência Do Estilo De Vida E Da Religiosidade

Portes¹,

Vieira²,

Carvalho³

et al. 2022

Alimentação, Nutrição E Cultura 2

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“…However, systemic treatment requires a relatively high dose, which can lead to severe side effects. Therefore, efforts are underway to develop techniques in which the thrombolytic drugs can exert their effects in a more targeted manner [50][51][52].…”

Section: Thrombolysismentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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Mechanisms of thrombosis and research progress on targeted antithrombotic drugs

Cited by 27 publications

References 235 publications

Antithrombotic Effect of Sorbus commixta in an Arterial Thrombosis Mouse Model

Antithrombotic Effect of Sorbus commixta in an Arterial Thrombosis Mouse Model

Estado Nutricional E Aptidão Física De Crianças E Adolescentes: Influência Do Estilo De Vida E Da Religiosidade

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

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